CAS: 889670-02-4; Methyl 2-((Tert-Butoxycarbonyl)Amino)-3-Iodopropanoate

该化合物是一种化学化合物,其结构特征包括:甲基酯,氨酸衍生物和乙氧碳基(Boc)保护组;在阿lanine脊柱的三处放置的碘原子,其存在具有独特的再活动性,使其在各种合成应用中,特别是在peptide合成和药用化学方面,有用.乙丁氧碳基-3-碘酸盐组是氨基功能的防护组,允许有选择的反应,而不会干扰矿物质.这种化合物一般在室温下是固体的,并且溶于二氯甲烷和二甲基硫氧化物等有机溶剂中,其稳定性和再活性可能受碘原子存在的影响,可参与核糖代谢反应.在合成更复杂的分子(包括药品)合成时,通常使用甲基N-(ter-toboxycolynyl)-3-碘酸盐.由于其功能组群状可以进一步修改,因此安全数据应当用于化学处理.

结构式图片

相似化合物

170848-34-7 93267-04-0 156017-42-4

物理性质

MSDS等安全信息

上下游产品

methyl (2S)-2-[N-(t-butoxycarbonyl)amino]-3-(4-methylbenzenesulfonyl)-oxypropionate (S)-2-tert-butoxycarbonylamino-3-methanesulfonyloxypropionic acid methyl ester N-tert-butyloxycarbonyl-L-serine methyl ester (S)-N-(tert-butoxycarbonyl)serine methyl 2-[(tert-butoxycarbonyl)amino]acrylate methyl (2S)-2-tert-butoxycarbonylamino-4-pentenoate (S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester (S)-2-tert-butoxycarbonylamino-hex-5-enoic acid methyl ester

合成工艺路线路线简述

  • 69961-11-1 = 889670-02-4
    反应条件:1.1 Reagents: Sodium Iodide Solvents: Acetone; 12 - 18 H,Reflux
    标题:Synthesis Of Highly Substituted Pyrrolidines Via Double Michael Addition Reaction And Its Anti-Microbial Activity
    作者:Chandan,Nandkishor
    参考文献:American Journal Of Pharmtech Research 日期:2016 卷标:6(5) 页码:640-647]

    69942-12-7 = 889670-02-4
    反应条件:1.1 Reagents: Imidazole,Triphenylphosphine Solvents: Dichloromethane; 10 Min,Rt; Rt -> 0 °C1.2 Reagents: Iodine; 40 Min,0 °C; 0 °C -> Rt; 10 Min,Rt; Rt -> 0 °C1.3 Solvents: Dichloromethane; 10 Min,0 °C; 1 H,0 °C; 0 °C -> Rt; 1.5 H,Rt
    标题:Nickel-Catalyzed Cross-Coupling Of Amino-Acid-Derived Alkylzinc Reagents With Alkyl Bromides/chlorides: Access To Diverse Unnatural Amino Acids
    作者:Gou,Fei-Hu; Ma,Ming-Jian; Wang,An-Jun; Zhao,Liang; Wang,Haoyang; Et Al
    参考文献:Organic Letters 日期:2022 卷标:24(1) 页码:240-244
📜Boc-Dl-丝氨酸置于咪唑,碘,Potassium Carbonate,三苯基膦体系中,用 二氯甲烷,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 6.5H,反应生成 N-Boc-3-碘丙氨酸甲酯
参考文献:Improved Synthetic Routes To The Selenocysteine Derivatives Useful For Boc-Based Peptide Synthesis With Benzylic Protection On The Selenium Atom
标题:Improved Synthetic Routes To The Selenocysteine Derivatives Useful For Boc-Based Peptide Synthesis With Benzylic Protection On The Selenium Atom
摘要:Selenocysteine (Sec) Derivatives,I.E.,Boc-Sec(Mbn)-Oh (1) And Boc-Sec(Mpm)-Oh (2),Which Are Useful For Chemical Synthesis Of Selenopeptides,Were Obtained From L-Serine In Five Steps With Total Yields Of 73% And 74%,Respectively. The Enantiomeric Excesses Were Confirmed To Be >99% E.E. By Optical Resolution Using A Chiral Column On HPLC. On The Other Hand,For The Case Of A Fmoc-Protected Sec Derivative,I.E.,Fmoc-Sec(Mpm)-Oh,Similar Reactions Resulted In Low Yields And Partial Racemization Taking Place.
DOI:10.3998/ark.5550190.P009.803

海关参考信息

专利信息


专利号:US-8993762-B2
优先权日:2013-03-15
标题 :Total synthesis of thaxtomin A analogues and their intermediates
发明人：HUANG HUAZHANG; YAN DONG; XUE ZHIJIE; ZHANG HONGBO
权利人:MARRONE BIO INNOVATIONS INC; MARRONE BIO INNOVATIONS INC
摘要:Improved synthetic methods for the production of thaxtomin analogs, particularly thaxtomin A, and intermediates therefore such as substituted tryptophans and in particular, 4-nitro-L-tryptophan, and substituted phenyl acrylic acids are disclosed. Bioassays show that the synthetic thaxtomin A is not significantly different from the natural one in herbicidal activity.

专利号:US-9187408-B2
优先权日:2008-10-27
标 题 :Process for the preparation of protected L-alanine derivatives
发明人：ANZALONE LUIGI; FEIBUSH PENINA; VILLANI FRANK J
权利人:JANSSEN PHARMACEUTICA NV; JANSSEN PHARMACEUTICA NV
摘要:The present invention is directed to a novel process for the preparation of protected L-alanine derivatives, useful as intermediates in the synthesis of compounds useful as mu/delta opioid modulators.

专利号:US-2014275541-A1
优先权日:2013-03-15
标 题 :Total synthesis of thaxtomin a analogues and their intermediates

专利号:WO-2014149171-A1
优先权日:2013-03-15
标 题 :Total synthesis of thaxtomin a analogues and their intermediates

专利号:US-9487523-B2
优先权日:2012-03-14
标题 :Process for making CGRP receptor antagonists
发明人：BELYK KEVIN M; CLEATOR EDWARD; KUO SHEN-CHUN; MALIGRES PETER EMMANUEL; XIANG BANGPING; YASUDA NOBUYOSHI; YIN JIANGUO
权利人:MERCK SHARP & DOHME
摘要:The invention encompasses a novel process for making piperidinone carboxamide indane and azainane derivatives, which are CGRP receptor antagonists useful for the treatment of migraine, utilizing a highly effective spiroacid synthesis.

专利号:US-9795613-B2
优先权日:2014-12-10
标题 :GLP-1 receptor modulators
发明人：BOEHM MARCUS F; MARTINBOROUGH ESTHER; MOORJANI MANISHA; TAMIYA JUNKO; HUANG LIMING; YEAGER ADAM R; BRAHMACHARY ENUGURTHI; FOWLER THOMAS; NOVAK ANDREW; MEGHANI PREMJI; KNAGGS MICHAEL; GLYNN DANIEL; MILLS MARK
权利人:CELGENE INT II SÀRL
摘要:Compounds are provided that modulate the glucagon-like peptide 1 (GLP-1) receptor, as well as methods of their synthesis, and methods of their therapeutic and/or prophylactic use. Such compounds can act as modulators or potentiators of GLP-1 receptor on their own, or with incretin peptides such as GLP-1(7-36) and GLP-1(9-36), or with peptide-based therapies, such as exenatide and liraglutide, and have the following general structure (where “ â€? represents either or both the R and S form of the compound): n nwhere A, B, C, Y 1 , Y 2 , Z, R 1 , R 2 , R 3 , R 4 , R 5 , W 1 , n, p and q are as defined herein.

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合成参考文献

参考DOI号:10.1002/anie.202006260
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