CAS: 836-43-1; (4-(Benzyloxy)Phenyl)Methanol

该化合物是一种多用途芳香酒精,通常用作有机合成和制药应用的中间体,其主要优点包括:稳定的苯并基氢氧基混合物,有利于选择性地发挥作用,并存在一种苯并基毒性,可增强有机溶剂中的溶解性.该化合物在保护群体战略和作为精化化学品的前体方面特别宝贵.其定义明确的再活性简介使其适合在复杂的分子构造中进行受控反应.高纯度的等级确保敏感合成工艺的一贯性能.建议根据标准实验室条件进行适当处理,因为该化合物对氧化具有中度的敏感性.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号4397-53-9 4-苄氧基苯甲醛 | CAS号623-05-2 对羟基苯甲醇 | CAS号100-39-0 溴化苄 | CAS号501-94-0 对羟基苯乙醇 | CAS号56441-55-5 4-(苄氧基)苯甲酸乙酯 | CAS号624286-53-9 trimethyl-[(4-p... | CAS号123-08-0 4-羟基苯甲醛; 对羟基苯甲醛 | CAS号112089-08-4 4-[[6-(dimethyl... | CAS号112089-09-5 N,N-dimethyl-9-... | CAS号55779-48-1 腔肠素 | CAS号52805-36-4 4-苯甲氧基苯甲腈 | CAS号4397-53-9 4-苄氧基苯甲醛 | CAS号51179-05-6 2-(4-苄氧基-苯基)-乙胺 | CAS号501-94-0 对羟基苯乙醇 | CAS号501-36-0 白藜芦醇 | CAS号50463-48-4 3-[4-(苄氧基)苯基]丙酸 | CAS号22171-15-9 4-苄氧基苄胺

合成工艺路线路线简述

  • 4397-53-9 = 836-43-1
    反应条件:1.1 Catalysts: Zirconium Tetrahydroxide (Partially Hydrated) Solvents: Isopropanol; 15 Min,60 °C
    标题:A Mild And Efficient Flow Procedure For The Transfer Hydrogenation Of Ketones And Aldehydes Using Hydrous Zirconia
    作者:Battilocchio,Claudio; Et Al
    参考文献:Organic Letters 日期:2013 卷标:15(9) 页码:2278-2281]

    56441-55-5 = 836-43-1
    反应条件:1.1 Reagents: Lithium Aluminum Hydride Solvents: Diethyl Ether
    标题:Solid Phase Diels-Alder/retro Diels-Alder Reactions. A New Method For Traceless Linker Strategy
    作者:Blanco,Luis; Et Al
    参考文献:Tetrahedron Letters 日期:2000 卷标:41(41) 页码:7875-7878]

    6547-53-1 = 836-43-1
    反应条件:1.1 Reagents: Cesium Carbonate,Oxygen,Sodium Borohydride Catalysts: Iridium(1+),[4,4′-Bis(1,1-Dimethylethyl)-2,2′-Bipyridine-Kn1,Kn1′]Bis[3,5-Diflu... Solvents: Dichloromethane; Rt -> 40 °C; 40 H,40 °C1.2 Reagents: Water
    标题:A General Method For Photocatalytic Decarboxylative Hydroxylation Of Carboxylic Acids
    作者:Khan,Shah Nawaz; Et Al
    参考文献:Journal Of Organic Chemistry 日期:2020 卷标:85(7) 页码:5019-5026]

    123-08-0 = 836-43-1
    反应条件:1.1 Reagents: Potassium Carbonate Solvents: Dimethylformamide; 70 Min,60 °C2.1 Reagents: Sodium Borohydride Solvents: Methanol; 0 °C; 1 H,Rt; Rt -> 0 °C2.2 Reagents: Water; 0 °C
    标题:Oxoammonium-Mediated Allylsilane-Ether Coupling Reaction
    作者:Carlet,Federica; Et Al
    参考文献:European Journal Of Organic Chemistry 日期:2021 卷标:2021(15) 页码:2162-2168]

    310396-74-8 = 836-43-1
    反应条件:1.1 Catalysts: Trifluoromethanesulfonic Acid (Silica Supported) Solvents: Methanol; 6 Min,Reflux
    标题:Silica Triflate As A New,Mild And Efficient Catalyst For Tetrahydropyranylation Of Alcohols And Deprotection Of Tetrahydropyranyl Ethers
    作者:Shirini,F.; Et Al
    参考文献:Phosphorus 日期:2007 卷标:182(9) 页码:2235-2240]

    310396-74-8 = 836-43-1
    反应条件:1.1 Reagents: Water Catalysts: β-Cyclodextrin Solvents: Methanol
    标题:Selective Deprotection Of Tetrahydropyranyl Ethers Catalyzed By β-Cyclodextrin In Water
    作者:Reddy,M. Arjun; Et Al
    参考文献:New Journal Of Chemistry 日期:2001 卷标:25(3) 页码:359-360]

    624286-53-9 = 836-43-1
    反应条件:1.1 Catalysts: Trifluoromethanesulfonic Acid (Silica Supported) Solvents: Methanol; 3 Min,Reflux
    标题:Silica Triflate As A New,Efficient,And Reusable Reagent For The Chemoselective Silylation Of Alcohols And Phenols And Deprotection Of Silyl Ethers
    作者:Shirini,F.; Et Al
    参考文献:Phosphorus 日期:2008 卷标:183(1) 页码:168-177]

    624286-53-9 = 836-43-1
    反应条件:1.1 Reagents: (T-4)-(Bromato-Ko)Tris(Nitrato-Ko)Cerium; 1 Min,Rt
    标题:(No3)3Cebro3. Solvent-Free Oxidation Of Alcohols And Deprotection And Oxidative Deprotection Of Trimethylsilyl Ethers
    作者:Shirini,Farhad; Et Al
    参考文献:Synthetic Communications 日期:2005 卷标:35(22) 页码:2913-2919]

    624286-53-9 = 836-43-1
    反应条件:1.1 Reagents: Cerate(2-),Nonakis(Nitrato-Ko)[μ3-[orthoperiodato(5-)-Ko:Ko′:Ko′′]]Tri-,Hydrog...; 5 Min,Rt
    标题:[ce(No3)3]3.H2Io6. Efficient Oxidation Reactions Under Solvent-Free Conditions
    作者:Shirini,F.; Et Al
    参考文献:Journal Of Chemical Research 日期:2006 卷标:(1) 页码:29-31]

    1058648-76-2 = 836-43-1
    反应条件:1.1 Catalysts: 12-Tungstophosphoric Acid Solvents: Ethanol; 3.5 H,Reflux
    标题:H3Pw12O40 - A Selective,Environmentally Benign,And Reusable Catalyst For The Preparation Of Methoxymethyl And Ethoxymethyl Ethers And Their Deprotection Under Mild Conditions
    作者:Mohammadpoor-Baltork,Iraj; Et Al
    参考文献:Canadian Journal Of Chemistry 日期:2008 卷标:86(8) 页码:831-840]

    32122-11-5 = 836-43-1
    反应条件:1.1 Reagents: Lithium Aluminum Hydride
    标题:Methanolysis (Solvolysis) And Synthesis Of 4'-Substituted 4-Benzyloxybenzyl Chlorides And Some Related Compounds: Comparisons With The Corresponding Benzoyl Compounds
    作者:Jorge,Jorge Armando Luis; Et Al
    参考文献:Journal Of The Chemical Society 日期:1981 卷标:(1) 页码:100-3]

    32122-11-5 = 836-43-1
    反应条件:1.1 Reagents: Sodium Tert-Butoxide Catalysts: Chloro[1,3-Dihydro-1-[2-[methyl[[(1-Methylethyl)Amino][(1-Methylethyl)Imino]Meth... Solvents: 1,4-Dioxane; 5 Min,40 °C1.2 Reagents: Hydrogen Catalysts: 15-Crown-5 Solvents: 1,4-Dioxane; Rt; 24 H,100 Bar,60 °C
    标题:A Bifunctional Copper Catalyst Enables Ester Reduction With H2: Expanding The Reactivity Space Of Nucleophilic Copper Hydrides
    作者:Zimmermann,Birte M.; Et Al
    参考文献:Chemrxiv 日期:2021 卷标:1 页码:1-9]

    623-05-2 = 836-43-1
    反应条件:1.1 Reagents: Potassium Carbonate Solvents: Acetone; 0.5 H,80 °C1.2 80 °C; 24 H,80 °C
    标题:Palladium/benzoic Acid-Catalyzed Regio- And Stereoselective Polymerization Of Internal Diynes And Diols Through C(Sp3)-H Activation
    作者:Wang,Jia; Et Al
    参考文献:Acs Macro Letters 日期:2019 卷标:8(9) 页码:1068-1074]

    623-05-2 = 836-43-1
    反应条件:1.1 Reagents: Cesium Carbonate Solvents: Acetonitrile; 18 H,25 °C
    标题:Discovery Of Highly Potent And Selective Benzyloxybenzyl-Based Peroxisome Proliferator-Activator Receptor (Ppar) δ Agonists
    作者:Bratton,Larry D.; Et Al
    参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2007 卷标:17(13) 页码:3624-3629]

    4397-53-9 = 836-43-1
    反应条件:1.1 Reagents: Silica (Chlorinated Silica),Lithium Aluminum Hydride Solvents: Diethyl Ether; 15 Min,Rt
    标题:Lialh4/silica Chloride As A New Chemoselective System For Reduction Of Carbonyl Compounds And Phosphine Oxides
    作者:Khalilzadeh,M. A.; Et Al
    参考文献:Journal Of The Iranian Chemical Society 日期:2008 卷标:5(4) 页码:699-705]

    4397-53-9 = 836-43-1
    反应条件:1.1 Reagents: Sodium Borohydride Solvents: Methanol; 1 H,Rt
    标题:Synthesis Of Ether Oligomers
    作者:Renaudet,Olivier; Et Al
    参考文献:Organic Letters 日期:2004 卷标:6(3) 页码:397-400]

    56441-55-5 = 836-43-1
    反应条件:1.1 Reagents: Lithium Aluminum Hydride Solvents: Diethyl Ether; 0 °C; 2 H,Rt
    标题:Soluble And Polymer-Supported 2- And 3-Benzylated Furans For The Preparation Of α,β-Ethylenic Carbonyl Compounds
    作者:Albert,Sebastien; Et Al
    参考文献:Tetrahedron 日期:2007 卷标:63(13) 页码:2888-2900]

    56441-55-5 = 836-43-1
    反应条件:1.1 Catalysts: Manganese(1+),[(1R)-1-[bis(4-Methoxy-3,5-Dimethylphenyl)Phosphino-Kp]-2-[(1R)-1... Solvents: Ethanol,Tert-Butanol; 22 H,100 °C
    标题:Manganese-Catalysed Transfer Hydrogenation Of Esters
    作者:Oates,Conor L.; Et Al
    参考文献:Chemical Communications (Cambridge 日期:2020 卷标:56(61) 页码:8635-8638]

    4397-53-9 = 836-43-1
    反应条件:1.1 Reagents: Sodium Borohydride Solvents: Methanol
    标题:Traceless Solid-Phase Synthesis Of Hydroxylated Cyclopentenones
    作者:Stathakis,Christos I.; Et Al
    参考文献:Tetrahedron Letters 日期:2008 卷标:49(48) 页码:6804-6806]

    84403-55-4 = 836-43-1
    反应条件:1.1 Reagents: Sodium Hydride,Sodium Iodide,Zinc Iodide Solvents: Tetrahydrofuran; 12 H,40 °C1.2 Solvents: Water; Ph 10,0 °C
    标题:Controlled Reduction Of Carboxamides To Alcohols Or Amines By Zinc Hydrides
    作者:Ong,Derek Yiren; Et Al
    参考文献:Angewandte Chemie 日期:2019 卷标:58(15) 页码:4992-4997]

    392717-83-8 = 836-43-1
    反应条件:1.1 Catalysts: 12-Tungstophosphoric Acid Solvents: Ethanol; 2 H,Reflux
    标题:H3Pw12O40 - A Selective,Environmentally Benign,And Reusable Catalyst For The Preparation Of Methoxymethyl And Ethoxymethyl Ethers And Their Deprotection Under Mild Conditions
    作者:Mohammadpoor-Baltork,Iraj; Et Al
    参考文献:Canadian Journal Of Chemistry 日期:2008 卷标:86(8) 页码:831-840]

    392717-83-8 = 836-43-1
    反应条件:1.1 Catalysts: 1-Methylimidazolium Hydrogen Sulfate; 2.5 Min,120 °C
    标题:Microwave-Assisted Rapid And Efficient Deprotection And Direct Esterification And Silylation Of Mom And Eom Ethers Catalyzed By [hmim][hso4] As A Bronsted Acidic Ionic Liquid
    作者:Mohammadpoor-Baltork,Iraj; Et Al
    参考文献:Monatshefte Fuer Chemie 日期:2010 卷标:141(10) 页码:1083-1088]

    = 836-43-1
    反应条件:1.1 Reagents: Sodium (In Silica Gel),Silica Solvents: Acetonitrile; 8 H,Rt
    标题:Decarbamoylation Of Primary Carbamates Using Sodium In Silica Gel (Na_sg)
    作者:Maurya,Chandra Kant; Et Al
    参考文献:Tetrahedron Letters 日期:2015 卷标:56(17) 页码:2228-2230]

    1058648-76-2 = 836-43-1
    反应条件:1.1 Catalysts: 1-Methylimidazolium Hydrogen Sulfate; 3 Min,120 °C
    标题:Microwave-Assisted Rapid And Efficient Deprotection And Direct Esterification And Silylation Of Mom And Eom Ethers Catalyzed By [hmim][hso4] As A Bronsted Acidic Ionic Liquid
    作者:Mohammadpoor-Baltork,Iraj; Et Al
    参考文献:Monatshefte Fuer Chemie 日期:2010 卷标:141(10) 页码:1083-1088]

    623-05-2 = 836-43-1 [标题:Reaction Conditions
    标题:Methanolysis (Solvolysis) And Synthesis Of 4'-Substituted 4-Benzyloxybenzyl Chlorides And Some Related Compounds: Comparisons With The Corresponding Benzoyl Compounds
    作者:Jorge,Jorge Armando Luis; Et Al
    参考文献:Journal Of The Chemical Society 日期:1981 卷标:(1) 页码:100-3]

    32122-11-5 = 836-43-1
    反应条件:1.1 Reagents: Sodium Tert-Butoxide Catalysts: Chloro[1,3-Dihydro-1-[2-[methyl[[(1-Methylethyl)Amino][(1-Methylethyl)Imino]Meth... Solvents: 1,4-Dioxane; 5 Min,40 °C1.2 Reagents: Hydrogen,15-Crown-5 Solvents: 1,4-Dioxane; Rt; 24 H,100 Bar,60 °C
    标题:A Bifunctional Copper Catalyst Enables Ester Reduction With H2: Expanding The Reactivity Space Of Nucleophilic Copper Hydrides
    作者:Zimmermann,Birte M.; Et Al
    参考文献:Journal Of The American Chemical Society 日期:2021 卷标:143(40) 页码:16865-16873
📜4-苄氧基苯乙酸置于sodium Tetrahydroborate,[ir(Df(Cf3)Ppy)2(Dtbbpy)](Pf6),氧气,Caesium Carbonate体系中,用 二氯甲烷 作为反应溶剂,化学反应 40.0H,以99%的收率获得产物4-苄氧基苄醇
参考文献:羧酸光催化脱羧羟基化反应的一般方法
标题:羧酸光催化脱羧羟基化反应的一般方法
摘要:通过使用分子氧作为绿色氧化剂的可见光诱导的光催化作用,开发了一种用于羧酸脱羧羟基化的通用方法.原位添加nabh 4可以减少不稳定的过氧自由基中间体,大大扩大了底物的范围.不同的含sp 3碳的羧酸已成功地用作底物,包括苯乙酸型底物以及脂肪族羧酸.该转化在伯,仲和叔羧酸上可以顺利进行.
DOI:10.1021/acs.Joc.0C00312

海关参考信息

专利信息


专利号:US-2019292219-A1
优先权日:2018-03-26
标 题:Method of solid-state peptide synthesis using a novel polymeric support
发明人：JERABEK KAREL; HANKOVA LIBUSE; HOLUB LADISLAV; ZECCA MARCO; CENTOMO PAOLO; TROVO DANIELE; LEDER RICCARDO; BIONDI BARBARA
权利人:INST OF CHEMICAL PROCESS FUNDAMENTALS OF THE CAS V V I; UNIV DEGLI STUDI PADOVA
摘要:A method of solid-state synthesis of peptides that provides a polymeric solid-state synthesis support, attaches a first amino acid to said support to form the first amino acid molecule of the desired peptide chain, attaches additional amino acids to form the desired peptide chain, characterized in that the polymeric solid-state synthesis support is a styrenic polymer containing at least 50 mol % divinylbenzene monomer units, the styrenic polymer being functionalized with chloromethyl and/or benzyloxybenzyl alcohol and/or amino moieties, and having porosity 60-90% and medium pore diameter ranging from 10 to 80 nm. A functionalized styrenic polymer is claimed.

专利号:US-2013267680-A1
优先权日:2010-09-15
标题:Total chemical synthesis of ubiquitin, ubiquitin mutants and derivatives thereof
发明人：OVAA HUIB; EL OUALID FARID; MERKX REMCO NICOLAAS SEBASTIAAN MICHEL
权利人:OVAA HUIB; EL OUALID FARID; MERKX REMCO NICOLAAS SEBASTIAAN MICHEL; STICHTING HET NL KANKERINST
摘要:The present invention relates to the field of total chemical synthesis of ubiquitin and related peptides. More in particular, a method is provided of solid phase synthesis of ubiquitin, ubiquitin mutants and derivatives thereof. It was the object of the present invention to provide an approach for the total chemical synthesis of ubuiqitin, which allows for the chemical synthesis of virtually any Ub mutant and giving high overall efficiency and purity. The present inventors have surprisingly found that this object can be realized with a method relying on incorporation of special amino acid building blocks. This approach was found to allow for exceptionally high yields of up to 14% and to provide an synthetic entry into virtually any ubiquitin derivative.

专利号:US-2003182068-A1
优先权日:2001-10-30
标 题 :Device and methods for directed synthesis of chemical libraries
发明人：BATTERSBY BRONWYN J; MILLER CHRISTOPHER R; TRAU MATHIAS; WAY JEFFERY C; JOHNSTON ANGUS
摘要:The invention features a sort computer which interfaces with a sorting device in order to control the sorting of beads on a bead by bead basis. The invention further features novel methods for the directed synthesis of encoded libraries of oligomers, e.g., oligonucleotides, on beads. These methods allow the synthesis of libraries that are sufficiently large to permit complex genomic analyses to be carried out. New methods of using the encoded libraries also are described.

专利号:EP-0790982-B1
优先权日:1994-06-17
标 题 :Methods of synthesis of peptidyl argininals
发明人：WEBB THOMAS R; REINER JOHN E; TAMURA SUSAN Y; RIPKA WILLIAM C; DAGNINO RAYMOND JR; NUTT RUTH F
权利人:CORVAS INT INC
摘要:This invention provides solution-phase and solid-phase methods for the synthesis of peptidyl argininals and to novel reagents useful therein, which have formula (I), wherein R1 is selected from the group consisting of hydrogen, benzyloxycarbonyl, isonicotinyloxycarbonyl, 2-chlorobenzyloxycarbonyl, 4-methoxybenzyloxycarbonyl, t-butoxycarbonyl, t-amyloxycarbonyl, isobornyloxycarbonyl, adamantyloxycarbonyl, 2-(4-biphenyl)-2-propyloxycarbonyl, 9-fluorenylmethoxycarbonyl and methylsulfonylethoxycarbonyl; R2 is selected from the group consisting of alkyl of 1 to about 12 carbon atoms and aralkyl of about 7 to about 15 carbon atoms, either of which is optionally substituted with hydroxy or -CO-Y, wherein Y is hydroxy, alkoxy of 1 to about 12 carbon atoms, aralkoxy of about 7 to about 15 carbon atoms, O-polymeric support or NH-polymeric support; R3 is selected from the group consisting of hydrogen, Fmoc, nitro, benzyloxycarbonyl, t-butoxycarbonyl and adamantyloxycarbonyl; and R4 is selected from the group consisting of hydrogen, alkyl of 1 to about 12 carbon atoms, aryl of about 6 to about 14 carbon atoms and aralkyl of about 7 to about 15 carbon atoms; and salts thereof.

专利号:US-2024018099-A1
优先权日:2020-11-19
标题 :Synthesis of prostate specific membrane antigen (psma) ligands
发明人：ANDREAE FRITZ
权利人:NOVARTIS AG
摘要:The present disclosure relates to the synthesis of prostate specific membrane antigen (PSMA) ligands that are useful in the treatment of diseases like cancer. In particular, the disclosure relates to a method for synthesizing PSMA ligands having a glutamate-urea-lysine (GUL) moiety and a chelating agent that can comprise a radiometal.

专利号:US-5731413-A
优先权日:1994-06-17
标 题:Method of synthesis of peptidyl aldehydes
发明人：WEBB THOMAS ROY; REINER JOHN EUGENE; TAMURA SUSAN YOSHIKO; RIPKA WILLIAM CHARLES; DAGNINO JR RAYMOND; NUTT RUTH FOELSCHE
权利人:CORVAS INT INC
摘要:This invention provides solution-phase and solid-phase methods for the synthesis of peptidyl argininals and to novel! reagents useful therein.

其他信息查阅

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

实用工具

⚠️全国化工行业净网倡议书
📋制造商识别码
📖 海关编码查询
📝MSDS生成器

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献

[参考文献]: Laurie A Witucki, Et Al. Identification Of Fak Substrate Peptides Via Colorimetric Screening Of A One-Bead One-Peptide Combinatorial Library. J Pept Sci. 2015 Apr;21(4):302-11.

合成参考文献


摘要:Braun, M., Science of Synthesis Knowledge Updates, (2017) 1, 465.
📝 需求与反馈
尽可能描述清楚需求与问题信息
×

通知