合成目标产物 Fomesafen 主要起始原料 Methanesulfonamide And Acifluorfen
(文献来源)合成步骤主要原料 Methanesulfonamide 和 Acifluorfen
N-Methanesulphonyl 3-(2-Chloro-α,α,α-Trifluoro-4-Tolyloxy)Benzamide置于硫酸,乙酸酐体系中,用 水 作为反应溶剂,化学反应生成 氟磺胺草醚 参考文献:Nitration Process 标题:Nitration Process 摘要:一种用硝酸或硝酸和硫酸混合物作为硝化试剂对芳香族或杂环芳香族化合物进行硝化的方法,其特征在于,硝化是在至少含有50%(体积/体积)的c.Sub.1-C.Sub.6烷基酯溶剂中进行的,该酯是c.Sub.1-C.Sub.4羧酸的酯.该方法特别适用于对二苯醚进行硝化,以产生可用作除草剂或用于合成除草剂的中间体的化合物.
专利号:WO-2024256370-A1 优先权日:2023-06-13 标 题 :Synthesis of glufosinate using an amidase-based process 发明人:ZIMMERMANN GUNTHER; POTT MORITZ STEFAN 权利人:BASF SE 摘要:The present invention relates to a method of preparing glufosinate, comprising the steps of hydrolysing an N-carbamoyl glufosinate amide with an Amidase enzyme to form an N- carbamoyl amino acid compound followed by cleaving off the carbamoyl moiety of said N- carbamoyl amino acid compound.
专利号:US-2025120400-A1 优先权日:2021-12-10 标题:Synthesis of glufosinate using a hydantoinase-based process 发明人:DITRICH KLAUS; BREUER MICHAEL; POTT MORITZ STEFAN; ZIMMERMANN GUNTHER; SEEMAYER STEFAN 权利人:BASF SE 摘要:The present invention relates to a method of manufacturing glufosinate, comprising the steps of hydrolysing a hydantoin with a Hydantoinase enzyme to form a N-carbamoyl amino acid compound followed by cleaving off the carbamoyl moiety of said N-carbamoyl amino acid compound.
专利号:US-11919928-B2 优先权日:2016-03-16 标题 :Method for producing dihydrotentoxin 发明人:KUBO TAKASHI; MACHIDA MASAYUKI; FUJIOKA TOMONORI; YAMAGUCHI Shigenari; KAWAI KIYOSHI 权利人:KUMIAI CHEMICAL INDUSTRY CO 摘要:An object of the present invention is to identify an enzyme having activity of synthesizing dihydrotentoxin that is a tentoxin precursor and an enzyme having activity of synthesizing tentoxin using dihydrotentoxin as a substrate. The present invention concerns a tentoxin synthesis-related gene encoding a protein comprising the amino acid sequence of SEQ ID NO: 16 and having activity of nonribosomal peptide synthesis of dihydrotentoxin and a tentoxin synthesis-related gene encoding a protein comprising the amino acid sequence of SEQ ID NO: 18 and having activity of converting dihydrotentoxin to tentoxin.
专利号:US-2021386068-A1 优先权日:2018-11-07 标题 :Compositions comprising pyridine carboxylate herbicides and very long chain fatty acid (vlcfa) synthesis inhibitor herbicides 发明人:KISTER JEREMY; SATCHIVI NORBERT M 权利人:CORTEVA AGRISCIENCE LLC 摘要:Disclosed herein are compositions comprising (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof and (b) a VLCFA synthesis inhibitor herbicide. Also disclosed herein are methods of controlling undesirable vegetation, comprising applying to vegetation or an area adjacent the vegetation or applying in soil or water to control the emergence or growth of vegetation (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof, and (b) a VLCFA synthesis inhibitor herbicide.
专利号:US-2021352899-A1 优先权日:2018-11-07 标题 :Compositions comprising pyridine carboxylate herbicides and fatty acid and lipid synthesis inhibitor herbicides 发明人:KISTER JEREMY; SATCHIVI NORBERT M 权利人:CORTEVA AGRISCIENCE LLC 摘要:Disclosed herein are compositions comprising (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof and (b) a fatty acid and lipid synthesis inhibitor (FA/LSI) herbicide, an agriculturally acceptable salt or ester thereof, or mixtures thereof. Also disclosed herein are methods of controlling undesirable vegetation, comprising applying to vegetation or an area adjacent the vegetation or applying in soil or water to control the emergence or growth of vegetation (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof and (b) a fatty acid and lipid synthesis inhibitor (FA/LSI) herbicide, an agriculturally acceptable salt or ester thereof, or mixtures thereof.
专利号:ES-2717283-T3 优先权日:2012-07-24 标 题:Herbicidal compositions comprising 4-amino-3-chloro-5-fluoro-6- (4-chloro-2-fluoro-3-methoxyphenyl) pyridine-2-carboxylic acid or a derivative thereof and herbicides inhibitors of VLCFA synthesis and synthesis of fatty acids / lipids
1: Khorram MS, Wang Y, Jin X, Fang H, Yu Y. Reduced mobility of fomesafen through enhanced adsorption in biochar-amended soil. Environ Toxicol Chem. 2015 Jun;34(6):1258-66. doi: 10.1002/etc.2946. Epub 2015 Apr 28. doi: 10.1007/s10661-013-3581-9. Epub 2013 Dec 22. doi: 10.1016/j.jhazmat.2014.03.041. Epub 2014 Mar 30. doi: 10.1007/s11356-014-3557-5. Epub 2014 Sep 23. doi: 10.1007/s11356-012-0962-5. Epub 2012 May 15. doi: 10.1021/jf3011307. Epub 2012 Jul 16. Chinese. doi: 10.1590/0001-3765201520140347. Epub 2015 Nov 27. doi: 10.1021/acs.jafc.6b01649. Epub 2016 Jun 15. doi: 10.1002/ps.4241. Epub 2016 Mar 4. 11: Krijt J, Stránská P, Sanitrák J, Chlumská A, Fakan F. Liver preneoplastic changes in mice treated with the herbicide fomesafen. Hum Exp Toxicol. 1999 May;18(5):338-44. Epub 2006 Aug 23. doi: 10.1016/j.chemosphere.2009.09.033. Epub 2009 Oct 20. doi: 10.1021/jf201731u. Epub 2011 Jun 30. doi: 10.1016/j.ecoenv.2008.08.001. Epub 2008 Oct 31.
合成参考文献
摘要:Pesticide Manual., 9(433), 1991 摘要:Syngenta Crop Protection, Inc; Product Label for Reflex Herbicide (2010). Available from, as of June 15, 2011: 摘要:MacBean C, ed; e-Pesticide Manual. 15th ed., ver. 5.1, Alton, UK; British Crop Protection Council. Fomesafen (72178-02-0) (2008-2010) 摘要:National Pesticide Information Retrieval System's USEPA/OPP Chemical Ingredients Database on Fomesafen sodium (108731-70-0). Available from, as of May 23, 2011: 摘要:Vidrine PR et al; Weed Technology 9 (1): 68-72 (1995)