CAS: 6754-13-8; Helenalin

上下游产品

-furan-2(3H)-one(3aα,4β,4aβ,5β,7aα,8α,9aβ)-3a,4,4a,5,7a,8,9,9a-°Ctahydro-4,5-dihydroxy-3-methylene-4a,8-dimethylazuleno6,5-b-furan-2(3H)-one -azylenofuran-2(3H)-one(3aα,4β,4aβ,5β,7aα,8α,9aβ)-3a,4,4a,5,7a,8,9,9a-°Ctahydro-8-hydroxy-4a,8-dimethyl-4-(tetrahydro-2H-pyran-2-yl)oxy-azyleno6,5-bfuran-2(3H)-one (3aS,4aR,5R,7aS,8S,9aR)-5-Benzyloxy-4a,8-dimethyl-3,3a,4a,5,7a,8,9,9a-°Ctahydro-azuleno[6,5-b]furan-2,4-dione (3aR,4R,4aS,5S,7aR,8R,9aS)-5-Benzyloxy-4a,8-dimethyl-4-(tetrahydro-pyran-2-yloxy)-3a,4,4a,5,7a,8,9,9a-°Ctahydro-3H-azuleno[6,5-b]furan-2-one2,3-epoxyhelenalin bis(helenalinyl) glutarate helenalin acetate bis(helenalinyl) malonate

📜(3Aα,4α,4Aβ,5β,7Aα,8α,9Aα)-3A,4,4A,5,7A,8,9,9A-octahydro-3-(Hydroxymethyl)-4A,8-Dimethyl-4,5-Bis<(Tetrahydro-2H-Pyran-2-yl)Oxy>Azuleno<6,5-B>Furan-2(3H)-One置于manganese(Iv) Oxide,1,8-二氮杂双环[5.4.0]十一碳-7-烯体系中,用 吡啶,二氯甲烷,水,溶剂黄146,苯 作为反应溶剂,化学反应 10.0H,反应生成 心菊内酯
参考文献:Pseudoguaianolides. 2. Stereocontrolled Total Synthesis Of The Helenanolide Dl-Helenalin
标题:Pseudoguaianolides. 2. Stereocontrolled Total Synthesis Of The Helenanolide Dl-Helenalin
摘要:
DOI:10.1021/ja00379A030

专利信息

专利号:US-12098115-B2
优先权日:2016-09-15
标 题:Methods and compositions for terpenoid synthesis
发明人：GRENNING ALEXANDER JAMES
权利人:UNIV FLORIDA
摘要:In one aspect, the disclosure relates to methods for preparation of terpene and terpene-like molecules. In a further aspect, the disclosure relates to the products of the disclosed methods, i.e., terpene and terpene-like molecules prepared using the disclosed methods. Intermediates for the synthesis of a wide variety of terpenoids are γ-allyl Knoevenagel adducts or quasi γ-allyl Knoevenagel adducts are disclosed. In various aspects, methods of preparing terpenoids through these intermediates are disclosed. The methods can comprise α-alkylation of an allylic electrophile followed by ring-closure metathesis to a polycyclic terpenoid structure. In a further aspect, the disclosure pertains to terpenoid frameworks, and compounds prepared via disclosed oxidation and substitution reactions on the disclosed terpenoid frameworks. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

专利号:US-12435055-B2
优先权日:2019-08-06
标 题 :3-methylideneoxan-4-one compounds and substituted derivates thereof as inhibitors of telomerase
发明人：SCHEIDT KARL A; BETORI RICK C
权利人:UNIV NORTHWESTERN
摘要:Disclosed are 3-methylideneoxan-4-one compounds, derivatives thereof, and methods of their synthesis and methods of their use in treating a disease or disorder in a subject in need thereof, such as diseases and disorders that are associated with telomerase activity such as cancer. The disclosed compounds may be formulated in a pharmaceutical composition for treating diseases and disorders that are associated with telomerase activity such as cancer.

专利号:CN-114957174-A
优先权日:2022-05-26
标 题:A kind of alkyl-substituted α-methylene-γ-butyrolactone derivative and synthesis method thereof

专利号:WO-9411382-A1
优先权日:1992-11-09
标题 :Antineoplastic heteronaphthoquinones
发明人：ATTARDO GIORGIO; BREINING TIBOR; COURCHESNE MARC; KRAUS JEAN-LOUIS; LAMOTHE SERGE; LAVALLEE JEAN-FRANCOIS; LEBEAU ELAINE; NGUYEN DIEU; REJ RABINDRA; ST-DENIS YVES; WANG WUYI; XU YAO-CHANG; BARBEAU FRANCE
权利人:IAF BIOCHEM INT; ATTARDO GIORGIO; BREINING TIBOR; COURCHESNE MARC; KRAUS JEAN LOUIS; LAMOTHE SERGE; LAVALLEE JEAN FRANCOIS; LEBEAU ELAINE; NGUYEN DIEU; REJ RABINDRA; ST DENIS YVES; WANG WUYI; XU YAO CHANG; BARBEAU FRANCE
摘要:Tricyclic heteronaphthoquinone derivatives, that have antineoplastic activity, are disclosed, together with processes for their synthesis. Some of these anti-neoplastics compounds have a saccharide moiety. Some members of this structurally distinct group exhibit activity against multiple drug resistant cancer cells.

专利号:US-7544375-B1
优先权日:2006-06-12
标 题:Composition
发明人：BELLIN HOWARD T; DE BORG BEATRICE
权利人:SWISS SKIN REPAIR INC
摘要:A topically applied composition or cream for treatment of the skin. A preferred composition includes a) a skin plumper; b) a tetrapeptide; c) a soya plant extract; d) Centella Asiatica extract; e) a cosmetic soothing or anti-inflammatory component; f) a component that acts on fibronectin synthesis; g) a moisturizing component; h) a structured conditioning component; i) an emulsifier component; and j) a transdermal delivery agent.