CAS: 629-72-1; 1-Bromopentadecane

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📜5-溴戊酸置于n,N'-二环己基碳二亚胺体系中,用 乙醚 作为反应溶剂,化学反应 62.0H,反应生成 溴代十五烷
参考文献:羧酸(II)的选择性混合偶联.-具有烯基,卤代,酮基,羧基和手性α-碳的不对称二酰基过氧化物的光解.与混合kolbe电解的比较
标题:羧酸(II)的选择性混合偶联.-具有烯基,卤代,酮基,羧基和手性α-碳的不对称二酰基过氧化物的光解.与混合kolbe电解的比较
摘要:制备烯基酰基和官能化的烷酰基十二烷酰过氧化物,产率为70%至97%,并在-78oc下光解.因此,4至10个烯酰基和4-烷酰过氧化物可提供非常好的产率(56-68%)的不对称偶联产物.类似地,可以将α-与σ-卤代烷酰基,胆酰基或3-和4-羧基烷酰基过氧化物偶联(40-70%).α-手性二酰基过氧化物ls经历光化学偶联反应,其构型保留80%.在电解失败或产率低的情况下,在-78oc下二酰过氧化物的光解被证明是kolbe电解的有利补充.
DOI:10.1016/s0040-4020(01)97195-9

专利信息

专利号:US-5656662-A
优先权日:1990-01-12
标 题:Synthesis of optically pure 4-alkenyl- or 4-alkanyl-2-hydroxytetronic acids
发明人：MANTRI PADMAJA; WITIAK DONALD T
权利人:UNIV OHIO STATE RES FOUND
摘要:The present invention relates to a method for synthesis of optically pure 4-alkenyl or 4-alkanyl-2-hydroxytetronic acids from an optically pure aldehyde. The invention further relates to the use of such optically pure compounds as potent inhibitors of platelet aggregation by working at the level of cyclooxygenase, thus making them useful in the treatment of coronary artery diseases, especially atherosclerosis, and additionally, as inhibitors of various inflammatory cytokines, making them useful in the treatment of both acute and chronic inflammation, as well in the treatment of cachexia, rheumatoid arthritis, multiple sclerosis, Crohn's disease and ulcerative colitis. The invention further relates to pharmaceutical compositions of the instant compounds.

专利号:US-5504107-A
优先权日:1990-01-12
标题 :Optically pure 4-alkenyl- or 4-alkanyl-2-hydroxytetronic acids and pharmaceutical use thereof
发明人：MANTRI PADMAJA; WITIAK DONALD T
权利人:UNIV OHIO STATE RES FOUND
摘要:The present invention relates to a method for synthesis of optically pure 4-alkenyl or 4-alkanyl-2-hydroxytetronic acids from an optically pure aldehyde. The invention further relates to the use of such optically pure compounds as potent inhibitors of platelet aggregation by working at the level of cyclooxygenase. The invention further relates to the pharmaceutical use of such compounds in the treatment of coronary artery diseases, especially in the treatment and/or prevention of atherosclerosis.

专利号:WO-9532194-A1
优先权日:1994-05-19
标题 :Synthesis of optically pure 4-alkenyl- or 4-alkanyl-2-hydroxytetronic acids

专利号:EP-0804430-A1
优先权日:1994-05-19
标 题:Synthesis of optically pure 4-alkenyl- or 4-alkanyl-2-hydroxytetronic acids

专利号:US-12410142-B2
优先权日:2017-04-07
标 题:Substituted imidazole salt compounds, preparation method thereof, pharmaceutical composition thereof and application thereof
发明人：DENG XIANMING; LIN SHENGCAI; ZHANG CHENSONG
权利人:XIAMEN VIVOHEALTHS TECH CO LTD
摘要:Disclosed in the invention are a type of compounds having aldolase selective inhibitory activity, a method for the preparation thereof, a pharmaceutical composition comprising the same, and use of these compounds in the manufacture of a medicament for inhibiting triglyceride and cholesterol synthesis, for reducing fatty acid synthesis, for preventing and/or treating obesity and type II diabetes, for preventing and/or treating tumor, for preventing and/or treating Parkinson's disease, for preventing and/or treating Alzheimer's disease or for prolonging the lifespan of mammals:

专利号:CN-113412835-B
优先权日:2021-07-28
标 题 :Synthesis method of a novel clothes moth pheromone component