专利号:US-11505815-B2 优先权日:2017-11-14 标题 :Compositions and methods related to non-templated enzymatic nucleic acid synthesis 发明人:CHEN MICHAEL C; MCINROY GORDON R 权利人:NUCLERA NUCLEICS LTD 摘要:The invention relates to the use of an amine masked moiety in a method of enzymatic nucleic acid synthesis. The invention also relates to said amine masked moieties per se and a process for preparing nucleotide triphosphates comprising said amine masked moieties.
专利号:WO-2024200820-A1 优先权日:2023-03-30 标 题:Method of synthesis of targeted lipid nanoparticle and uses thereof
专利号:US-4082911-A 优先权日:1975-02-24 标题 :Process for the preparation of nucleosides 发明人:VORBRUGGEN HELMUT 权利人:SCHERING AG 摘要:The use of trialkylsilyl ester catalysts in place of Lewis acid or Friedel-Crafts catalysts in nucleoside synthesis gives increased yields and a simplified working-up process for recovering the nucleoside product.
专利号:WO-0231176-A1 优先权日:2000-10-12 标题:Process for producing nucleoside 发明人:FUJIWARA JUNYA; KOMATSU HIRONORI; AWANO HIROKAZU; FUKAZAWA NOBUYUKI; ANDO TOMOYUKI; TSUCHIYA KATSUTOSHI; CHIBA KYOKO; UMETANI HIDEKI; ARAKI TADASHI; YAMAUCHI TAKAHIRO 权利人:MITSUI CHEMICALS INC; FUJIWARA JUNYA; KOMATSU HIRONORI; AWANO HIROKAZU; FUKAZAWA NOBUYUKI; ANDO TOMOYUKI; TSUCHIYA KATSUTOSHI; CHIBA KYOKO; UMETANI HIDEKI; ARAKI TADASHI; YAMAUCHI TAKAHIRO 摘要:An anomer mixture of a nonnatural 1-phosphorylated saccharide is reacted with a base by the action of phosphorylase activity, wherein the exchange reaction between the phosphate group of the 1-phosphorylated saccharide and the base is conducted anomer-selectively. Metal cations capable of forming a sparingly water-soluble salt with phosphate ions are caused to be present in the reaction mixture, whereby the phosphate ions which are a by-product of the reaction can be precipitated as a sparingly water-soluble salt and the reaction equilibrium can be shifted toward nucleoside synthesis. Thus, the yield of the target compound is heightened. By utilizing a difference in the rate of the exchange reaction, a mixture of optical isomers of the nucleoside can be obtained in which one of the isomers is contained in a higher proportion.
专利号:EP-1179598-B1 优先权日:1999-05-13 标题 :Process for producing nucleoside compound 发明人:NIKUMARU SEIYA; NAKAMURA TAKESHI 权利人:MITSUI CHEMICALS INC 摘要:In preparation of a nucleoside compound by reacting a pentose-1-phosphate and a nucleic acid base or its analogue in the presence of enzyme activity of nucleoside phosphorylase, a metal salt capable of forming a water-insoluble salt with phosphoric acid may be added to a reaction system to eliminate phosphoric acid, a byproduct, from the reaction system so that the equilibrium reaction can be shifted toward a direction for nucleoside synthesis, leading to an improved yield of the desired nucleoside compound.
参考文献:10.1021/jm9006356 摘要:Borrmann T, Abdelrahman A, Volpini R, Lambertucci C, Alksnis E, Gorzalka S, Knospe M, Schiedel AC, Cristalli G, Müller CE. Structure-activity relationships of adenine and deazaadenine derivatives as ligands for adenine receptors, a new purinergic receptor family. J Med Chem. 2009 Oct 08;52(19):5974–89. doi: 10.1021/jm9006356.