CAS: 6034-68-0; N-(7H-Purin-6-yl)Acetamide

该化合物是一种纯衍生物,其结构特征具有其结构特征,包括纯环系统和乙酰胺功能组.该化合物一般是白色的,是白色的,是非白色固体的,在水和二甲基硫氧化(DMSO)等极地溶剂中可溶解的.该化合物展示了生物活动,经常就其在生物化学途径中的潜在作用进行研究,特别是与核酸代谢和细胞信号有关的潜在作用进行研究.该氨组的存在有助于其与生物巨型分子的再活动及潜在互动.作为一个化学实体,它在医药化学和药理学中是重要的,它可以作为药物开发的铅化合物或作为生物化学探测器.应当参考安全数据,用于处理和储存,与任何化学物质一起,以确保适当的实验室做法.

结构式图片

上下游产品

acetic anhydride 7H-purin-6-ylamine adenosine5',5'-2H2adenosine ethyl adenosine-5'-carboxylate (9)H-purin-6-yl)-amineethyl-(7(9)H-purin-6-yl)-amine 6-N-acetyl-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-O,4'-C-(N-methylaminomethylene) adenosine 9-propenyladenine (R)-9-(2-hydroxypropyl)adenine

合成工艺路线路线简述

    📜Ethyl Adenosine-5'-Carboxylate置于硼氘化钠体系中,用 乙醇 作为反应溶剂,化学反应 34.0H,反应生成 乙酰氨基嘌呤
    参考文献:Mass Spectrometry Of Nucleic Acid Constituents. Trimethylsilyl Derivatives Of Nucleosides
    标题:Mass Spectrometry Of Nucleic Acid Constituents. Trimethylsilyl Derivatives Of Nucleosides
    摘要:
    DOI:10.1021/jo00141A023

    海关参考信息

    专利信息


    专利号:US-11505815-B2
    优先权日:2017-11-14
    标题 :Compositions and methods related to non-templated enzymatic nucleic acid synthesis
    发明人:CHEN MICHAEL C; MCINROY GORDON R
    权利人:NUCLERA NUCLEICS LTD
    摘要:The invention relates to the use of an amine masked moiety in a method of enzymatic nucleic acid synthesis. The invention also relates to said amine masked moieties per se and a process for preparing nucleotide triphosphates comprising said amine masked moieties.

    专利号:WO-2024200820-A1
    优先权日:2023-03-30
    标 题:Method of synthesis of targeted lipid nanoparticle and uses thereof

    专利号:US-4082911-A
    优先权日:1975-02-24
    标题 :Process for the preparation of nucleosides
    发明人:VORBRUGGEN HELMUT
    权利人:SCHERING AG
    摘要:The use of trialkylsilyl ester catalysts in place of Lewis acid or Friedel-Crafts catalysts in nucleoside synthesis gives increased yields and a simplified working-up process for recovering the nucleoside product.

    专利号:WO-0231176-A1
    优先权日:2000-10-12
    标题:Process for producing nucleoside
    发明人:FUJIWARA JUNYA; KOMATSU HIRONORI; AWANO HIROKAZU; FUKAZAWA NOBUYUKI; ANDO TOMOYUKI; TSUCHIYA KATSUTOSHI; CHIBA KYOKO; UMETANI HIDEKI; ARAKI TADASHI; YAMAUCHI TAKAHIRO
    权利人:MITSUI CHEMICALS INC; FUJIWARA JUNYA; KOMATSU HIRONORI; AWANO HIROKAZU; FUKAZAWA NOBUYUKI; ANDO TOMOYUKI; TSUCHIYA KATSUTOSHI; CHIBA KYOKO; UMETANI HIDEKI; ARAKI TADASHI; YAMAUCHI TAKAHIRO
    摘要:An anomer mixture of a nonnatural 1-phosphorylated saccharide is reacted with a base by the action of phosphorylase activity, wherein the exchange reaction between the phosphate group of the 1-phosphorylated saccharide and the base is conducted anomer-selectively. Metal cations capable of forming a sparingly water-soluble salt with phosphate ions are caused to be present in the reaction mixture, whereby the phosphate ions which are a by-product of the reaction can be precipitated as a sparingly water-soluble salt and the reaction equilibrium can be shifted toward nucleoside synthesis. Thus, the yield of the target compound is heightened. By utilizing a difference in the rate of the exchange reaction, a mixture of optical isomers of the nucleoside can be obtained in which one of the isomers is contained in a higher proportion.

    专利号:EP-1179598-B1
    优先权日:1999-05-13
    标题 :Process for producing nucleoside compound
    发明人:NIKUMARU SEIYA; NAKAMURA TAKESHI
    权利人:MITSUI CHEMICALS INC
    摘要:In preparation of a nucleoside compound by reacting a pentose-1-phosphate and a nucleic acid base or its analogue in the presence of enzyme activity of nucleoside phosphorylase, a metal salt capable of forming a water-insoluble salt with phosphoric acid may be added to a reaction system to eliminate phosphoric acid, a byproduct, from the reaction system so that the equilibrium reaction can be shifted toward a direction for nucleoside synthesis, leading to an improved yield of the desired nucleoside compound.

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    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    参考文献:10.1021/jm9006356
    摘要:Borrmann T, Abdelrahman A, Volpini R, Lambertucci C, Alksnis E, Gorzalka S, Knospe M, Schiedel AC, Cristalli G, Müller CE. Structure-activity relationships of adenine and deazaadenine derivatives as ligands for adenine receptors, a new purinergic receptor family. J Med Chem. 2009 Oct 08;52(19):5974–89. doi: 10.1021/jm9006356.
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