CAS: 56651-57-1; 4-Methylbenzylisocyanate

上下游产品

CAS号530-62-1 N,N'-羰基二咪唑(CDI) | CAS号104-84-7 4-甲基苄胺 | CAS号35675-44-6 对甲苯乙酰氯 | CAS号32315-10-9 三光气 | CAS号622-47-9 对甲苯乙酸 | CAS号6212-86-8 Benzeneacetamid... | CAS号7093-91-6 CHLOROMETHYL IS... | CAS号108-88-3 甲苯 | CAS号37389-92-7 1,3-bis[(4-meth...

📜对甲基苯乙酸置于叠氮磷酸二苯酯,三乙胺体系中,化学反应生成 4-甲基苄基异氰酸酯
参考文献:Inhibition Of Serine Proteases: Activity Of 1,3-Diazetidine-2,4-Diones
标题:Inhibition Of Serine Proteases: Activity Of 1,3-Diazetidine-2,4-Diones
摘要:The Present Work Demonstrates That The 1,3-Diazetidifie-2,4-Dione Nucleus Is Effective As A Scaffold Of Serine Protease Inhibitors. Compound 1 Displayed High Activity Against Human Cathepsin G And Alpha-Chymotrypsin (0.39,0.69 Nm). Compound 6 Exhibited 0.85 Nm Inhibition Of Human Chymase. Compound 10 Was A Selective Inhibitor Against Human Neutrophil Elastase. (C) 2001 Elsevier Science Ltd. All Rights Reserved.
DOI:10.1016/s0960-894X(01)00264-5

专利信息

专利号:US-9878999-B2
优先权日:2011-03-24
标题 :Proteasome chymotrypsin-like inhibition using PI-1833 analogs
发明人：LAWRENCE HARSHANI R; SEBTI SAID M; OZCAN SEVIL
权利人:H LEE MOFFITT CANCER CT & RES
摘要:Focused library synthesis and medicinal chemistry on an oxadiazole-isopropylamide core proteasome inhibitor provided the lead compound that strongly inhibits CT-L activity. Structure activity relationship studies indicate the amide moiety and two phenyl rings are sensitive toward synthetic modifications. Only para-substitution in the A-ring was important to maintain potent CT-L inhibitory activity. Hydrophobic residues in the A-ring's para-position and meta-pyridyl group at the B-ring significantly improved inhibition. The meta-pyridyl moiety improved cell permeability. The length of the aliphatic chain at the para position of the A-ring is critical with propyl yielding the most potent inhibitor, whereas shorter (i.e. ethyl, methyl or hydrogen) or longer (i.e. butyl, propyl and hexyl) chains demonstrating progressively less potency. Introduction of a stereogenic center next to the ether moiety (i.e. substitution of one of the hydrogens by methyl) demonstrated chiral discrimination in proteasome CT-L activity inhibition (the S-enantiomer was 35-40 fold more potent than the R-enantiomer).

专利号:US-10703852-B2
优先权日:2017-05-16
标题:Isocyanate composition for optical lenses and process for preparing the same
发明人：SHIN JUNGHWAN; HAN HYUK HEE; SHIM JONGMIN
权利人:SKC CO LTD
摘要:An isocyanate composition is prepared from an amine composition, which comprises (a) 99% to less than 100% by weight of m-xylylenediamine; (b) greater than 0% to 0.5% by weight of p-xylylenediamine; and (c) greater than 0% to 0.5% by weight of at least one selected from the group consisting of benzylamine, 4-methylbenzylamine, and 4-cyanobenzylamine. Therefore, the isocyanate composition used in the preparation of a polythiourethane can be controlled to a specific composition in the synthesis thereof, which makes it possible to conveniently produce an optical lens with a high quality.

专利号:US-6897262-B2
优先权日:2000-06-22
标 题 :Scavenger resin and processes for the use thereof
发明人：PEARS DAVID ALAN
权利人:AVECIA LTD
摘要:Scavenger resins comprising pendant groups specific for the removal of primary amines form solution in the presence of secondary amines are provided. Processes for the use of these scavenger resins, especially in solid phase synthesis, for the removal of primary amines from solution or for the removal of electrophiles from solution are provided.

专利号:CN-115385836-B
优先权日:2022-08-17
标 题 :Synthesis method of amino selenate compound