CAS: 554-92-7; N-(4-(2-(Dimethylamino)Ethoxy)Benzyl)-3,4,5-Trimethoxybenzamide Hydrochloride

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Trimethobenzamide 4-hydroxy-benzaldehyde 4-(2-dimethylaminoethoxy)benzaldehyde benzylamine4-2-(dimethylamino)ethoxybenzylamine

合成工艺路线路线简述

    📜4-[2-(二甲胺基)乙氧基]苯甲醛置于盐酸,氯化亚砜,氨,N,N-二甲基甲酰胺体系中,用 甲醇,水,丙酮 作为反应溶剂,50.0~55.0 °C,1.0 Mpa 条件下,反应 8.0H,反应生成 盐酸三甲氧苯酰胺
    参考文献:An Improved Process For Trimethobenzamide Hydrochloride
    标题:An Improved Process For Trimethobenzamide Hydrochloride
    摘要:An Improved Process For The Preparation Of Trimethobenzamide Hydrochloride Conforming To Regulatory Specification Is Reported. Specifically,A Process For The Preparation Of Trimethobenzamide Hydrochloride,Which Is Free From The Associated Impurities That Are Normally Encountered During Coupling Of 4-(2-Dimethylaminoethoxy)Benzyl Amine With 3,4,5-Trimethoxy Benzoic Acid Is Described.
    DOI:10.1021/op400113A

    海关参考信息

    专利信息


    专利号:WO-2009047423-A3
    优先权日:2007-09-13
    标 题 :Method for the synthesis of ticon, tion and tio nanoparticles by laser pyrolysis

    专利号:WO-2009047423-A2
    优先权日:2007-09-13
    标题:Method for the synthesis of ticon, tion and tio nanoparticles by laser pyrolysis

    专利号:US-2010308286-A1
    优先权日:2007-09-13
    标题:Method for the synthesis of ticon, tion and tio nanoparticles by laser pyrolysis

    专利号:EP-2185475-A2
    优先权日:2007-09-13
    标 题:Method for the synthesis of ticon, tion and tio nanoparticles by laser pyrolysis

    专利号:US-9486471-B2
    优先权日:2012-03-28
    标题:Combination therapy for the treatment of cancer
    发明人:BHATIA MICKIE; SACHLOS ELEFTHERIOS
    权利人:UNIV MCMASTER
    摘要:Described are methods and compositions for treating cancer that include a dopamine receptor (DR) antagonist such as thioridazine and a chemotherapeutic agent. Optionally, the chemotherapeutic agent is a DNA synthesis inhibitor such as cytarabine or a microtubule inhibitor such as paclitaxel or docetaxel. The methods and compositions are useful for the treatment of cancers such as acute myeloid leukemia.

    专利号:FR-2921056-A1
    优先权日:2007-09-13
    标题:PROCESS FOR THE SYNTHESIS OF TICON NANOPARTICLES AND LASER PYROLYSIS TION.

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    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Hauser RA, Isaacson S, Clinch T; Tigan/Apokyn Study Investigators. Randomized, placebo-controlled trial of trimethobenzamide to control nausea and vomiting during initiation and continued treatment with subcutaneous apomorphine injection. Parkinsonism Relat Disord. 2014 Nov;20(11):1171-6. doi: 10.1016/j.parkreldis.2014.08.010. Epub 2014 Aug 27. doi: 10.3109/14767058.2010.536867. Epub 2010 Dec 7.

    合成参考文献


    参考文献:10.1038/ncb3255
    摘要:Lin R, Elf S, Shan C, Kang HB, Ji Q, Zhou L, Hitosugi T, Zhang L, Zhang S, Seo JH, Xie J, Tucker M, Gu TL, Sudderth J, Jiang L, Mitsche M, DeBerardinis RJ, Wu S, Li Y, Mao H, Chen PR, Wang D, Chen GZ, Hurwitz SJ, Lonial S, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Lei Q, Brat DJ, Ye K, Boggon TJ, He C, Kang S, Fan J, Chen J. 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. Nat Cell Biol. 2015 Nov;17(11):1484–96.
    摘要:
    摘要:Journal of Pharmacology and Experimental Therapeutics., 126(270), 1959 []
    摘要:Archives Internationales de Pharmacodynamie et de Therapie., 174(350), 1968 []
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