专利号:US-2025162968-A1 优先权日:2022-02-02 标 题 :Method for Producing Ionizable Lipids or Intermediates for the Synthesis of Such Lipids 发明人:ATMURI N D PRASAD; ARNOLD DEAGLAN; SAADATI FARIBA; KUREK DANIEL; KULKARNI JAYESH; WITZIGMANN DOMINIK; CIUFOLINI MARCO A 权利人:NANOVATION THERAPEUTICS INC 摘要:The present disclosure provides a method for producing one or more intermediates for the synthesis of one or more ionizable lipids, the method comprising: (i) producing a beta-ketoacid by reacting a cyclic ester, a terminal hydroxyester or a derivative thereof, a dicarboxylic acid half ester, or an acid chloride derivative of the dicarboxylic acid half ester, in a condensation reaction, thereby producing the beta-ketoacid or a beta-ketoester that is hydrolyzed to produce the beta-ketoacid; and (ii) decarboxylating the beta-ketoacid, thereby producing the one or more intermediates, wherein the one or more intermediates have a structure that may be defined by Formula A. Further provided is a method for producing ionizable lipid from the intermediate comprising adding an ionizable head group moiety to (a) a ketone group of one or more intermediates having the structure that may be defined by Formula A; or (b) a corresponding alcohol of the intermediate.
专利号:WO-2017171674-A1 优先权日:2016-03-22 标题 :Synthesis of attractant of pistachio twig borer (kermania pistaciella) 发明人:ABDULKADIR SIRIT 权利人:ABDULKADIR SIRIT 摘要:The present invention relates to the stereoselective synthesis (2S,12Z)-2-acetoxy-12-heptadecene secreted by female pistachio twig borer and attract male individuals.
专利号:US-2025122236-A1 优先权日:2021-06-09 标题 :Intermediate for preparing fulvestrant and preparation method therefor 发明人:ZHANG FUYAO; CHEN XIANJIE 权利人:SHANGHAI BEST LINK BIOSCIENCE LLC 摘要:The invention relates to a fulvestrant intermediate and a preparation method thereof. Specifically, the invention relates to a compound shown as a formula V and a preparation method thereof, and R 1 is hydrogen or a hydroxyl protecting group. The invention also relates to a preparation method for the synthesis of fulvestrant from the compound as shown in the formula V. The method has the advantages of short reaction steps, mild and safe reaction conditions, high selectivity, simplicity and convenience in operation and purification, high synthesis efficiency and the like, and is suitable for large-scale production.
专利号:WO-2023147657-A1 优先权日:2022-02-02 标题 :Method for producing ionizable lipids or intermediates for the synthesis of such lipids
专利号:US-9957286-B2 优先权日:2012-11-20 标题 :Method for the synthesis of solid heterogeneous chiral catalysts and their use in stereoselective reactions 发明人:GALINDO ESQUIVEL IGNACIO RENE; JUAREZ RUIZ JUAN MANUEL; REGALADO OLIVA ORLANDO 权利人:UNIV GUANAJUATO 摘要:This invention describes the methodology to produce solid heterogeneous chiral organocatalysts that can be used in condensation reactions. The catalysts can be recovered in a simple manner by filtration and can also be reused.
专利号:EP-4472941-A1 优先权日:2022-02-02 标 题 :Method for producing ionizable lipids or intermediates for the synthesis of such lipids
[参考文献]: Néstor M Carballeira, Et Al. First Total Syntheses Of (Z)-15-Methyl-10-Hexadecenoic Acid And The (Z)-13-Methyl-8-Tetradecenoic Acid. Chem Phys Lipids. 2007 Jan;145(1):37-44.
合成参考文献
参考文献:10.1007/s10886-014-0446-9 摘要:Yan Q, Vang LV, Khanh CNQ, Naka H, Ando T. Reexamination of the Female Sex Pheromone of the Sweet Potato Vine Borer Moth: Identification and Field Evaluation of a Tricosatriene. Journal of Chemical Ecology. 2014 May 31;40(6):590–8. doi: 10.1007/s10886-014-0446-9.