CAS: 53643-53-1; N-(4-Methoxystyryl)Formamide

专利信息

专利号:US-12049470-B2
优先权日:2021-02-01
标 题 :MK2 inhibitors, the synthesis thereof, and intermediates thereto
发明人：RUCHELMAN ALEXANDER L; COOMBS JOHN R; ZHU KEMING; LIM DANIEL; JOE CANDICE LEE; GEORGE DAVID T; ZHENG BIN; LIN DONG
权利人:CELGENE CORP
摘要:The present disclosure provides novel synthetic intermediates useful in the synthesis of MK2 kinase inhibitors.

专利号:US-5130472-A
优先权日:1990-01-16
标题 :Total synthesis of erbstatin analogs
发明人：BUZZETTI FRANCO; CRUGNOLA ANGELO; LOMBARDI PAOLO
权利人:ERBA CARLO SPA
摘要:The present invention relates to a new process for the preparation of Erbstatin and Erbstatin analogs, which can be represented by the following formula (I) ##STR1## wherein R is hydrogen, a lower alkyl or a lower alkanoyl group; n n is an integer of 1 to 3; n A is --CHâ•?CH-- or --CH 2 --CH 2 --; n R 1 is hydrogen or a lower alkyl group, and n R 2 is a hydrogen or halogen atom.

专利号:WO-0032619-A1
优先权日:1998-11-30
标题:Methods and compositions for identification of inhibitors of ribosome assembly
发明人：DAMMEL CAROL S; WATSON JULIE C
权利人:RIBOGENE INC
摘要:The invention provides a means for identifying novel antibiotics by screening for compounds that inhibit bacterial ribosome assembly and ribosomal protein synthesis, which comprises the screening of test compounds to identify those that inhibit the activity of a bacterial ribosomal protein. The in vitro and in vivo assays detect (a) increased translation of a reporter mRNA that is normally repressed in the presence of a ribosomal protein, (b) increased growth in cells that over-express ribosomal protein, and (c) decreased binding of the ribosomal protein to its target RNA. The invention encompasses the (a) methods of screening and testing compounds by the above methods, (b) compounds that are identified in the assay which inhibit ribosome assembly and protein synthesis and (c) methods for treatment using said compounds.

专利号:US-7799906-B1
优先权日:2004-09-22
标题 :Compositions and methods for modulating lignin of a plant
发明人：ROTTMANN WILLIAM H; CONNETT MARIE B; BLOKSBERG LEONARD N; FORSTER RICHARD L
权利人:ARBORGEN LLC
摘要:Novel plant monolignol synthesis, monolignol transport, and lignin polymerization genes and polypeptides encoded by such genes are provided. These genes and polynucleotide sequences are useful regulating the lignification process and plant phenotype. Moreover, these genes are useful for expression profiling of plant monolignol synthesis, monolignol transport, and lignin polymerization genes. The invention specifically provides polynucleotide and polypeptide sequences isolated from Eucalyptus and Pinus.

专利号:US-11655257-B2
优先权日:2017-03-16
标 题:MK2 inhibitors, synthesis thereof, and intermediates thereto
发明人：FEIGELSON GREGG BRIAN; GEHERTY MARYLL E; HEID JR RICHARD MARTIN; KOTHARE MOHIT; MAN HON-WAH; RUCHELMAN ALEXANDER L; TRAVERSE JOHN F; YONG KELVIN HIN-YEONG; ZHANG CHENGMIN
权利人:CELGENE CAR LLC
摘要:The present invention provides methods of preparing a MK2 inhibitor, and intermediates related thereto.

专利号:US-9149445-B2
优先权日:2009-07-27
标 题:Inhibition of glycerol-3-phosphate acyltransferase (GPAT) and associated enzymes for treatment of viral infections
发明人：LIU SEAN; RABINOWITZ JOSHUA D; SHENK THOMAS
权利人:LIU SEAN; RABINOWITZ JOSHUA D; SHENK THOMAS; UNIV PRINCETON
摘要:A method of treating or preventing a viral infection in a mammal by administering a compound or pharmaceutically acceptable derivative thereof that inhibits a phosphatidic acid synthesis enzyme.