CAS: 5255-75-4; 2-((4-Nitrophenoxy)Methyl)Oxirane

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CAS号115314-14-2 3-硝基苯磺酸(|S|)-缩水甘油基酯 | CAS号824-78-2 4-硝基苯酚钠 | CAS号137941-92-5 N-[4-[3-[methyl...

📜4-Nitrophenol Sodium Salt置于间氯过氧苯甲酸体系中,用 二氯甲烷,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 96.0H,反应生成 2-[(4-硝基苯氧基)甲基]环氧乙烷
参考文献:新型n-杂芳烷基取代的1-(芳氧基)-2-丙醇胺及相关丙胺衍生物的合成及ⅲ类抗心律失常活性.
标题:新型n-杂芳烷基取代的1-(芳氧基)-2-丙醇胺及相关丙胺衍生物的合成及ⅲ类抗心律失常活性.
摘要:描述了一系列新型的1-(芳氧基)-2-丙醇胺和几种相关的脱羟基类似物的合成和生物学评估.制备了化合物4-29,并在分离的犬浦肯野纤维和麻醉的开胸狗中研究了它们的iii类电生理活性.这些化合物均未显示出任何i类活性.基于体外数据,讨论了该系列的结构-活性关系.n-[4-[2-羟基-3-[甲基(2-喹啉基甲基)氨基]丙氧基]苯基]甲磺酰胺(12,Way-123,223)和n-[2-[[甲基[3-[4]鉴定了[[[(甲基磺酰基)氨基]苯氧基]丙基]氨基]甲基]-6-喹啉基]-甲磺酰胺(24,Way-125,971),并在体外和体内鉴定为有效的和特定的iii类抗心律不齐药物.已发现化合物12具有口服生物利用度,可大幅提高心室纤颤阈值(vft),并且在某些情况下,以5 Mg / Kg的剂量在麻醉的开胸狗中可恢复室颤的窦性心律(iv).合成了12个对映体(即13和14),并在purkin
DOI:10.1021/jm00115A010

专利信息

专利号:US-10954197-B2
优先权日:2017-03-08
标 题 :Cathepsin-D and angiogenesis inhibitors and compositions thereof for treating breast cancer
发明人：YOGEESWARI PERUMAL
权利人:YOGEES BIOINNOVATIONS PRIVATE LTD
摘要:Cathepsin-D and angiogenesis inhibitors and compositions thereof for treating breast cancer are provided. More particularly, the embodiments relate to the design and synthesis of inhibitors of Cathepsin D, which exhibits antiproliferative activity and also inhibits angiogenesis. Also provided are compositions thereof for treating breast cancer.

专利号:US-3953604-A
优先权日:1972-01-14
标 题:1-(2-Substituted-chromonyloxy)-2-hydroxy-3-(substituted phenoxy)propanes
发明人：WARREN BRIAN THOMAS; SPICER JOHN WILLIAM
权利人:MILES LAB
摘要:Definitions: in the following Formulae I, II and IV, R 1 represents hydrogen, alkyl of 1 to 4 carbon atoms, or a nontoxic cation, while each of R 2 , R 3 , R 4 , R 5 , and R 6 symbolizes hydrogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, carboxy, carbalkoxy of 1 to 4 carbon atoms, trihalomethyl, halogen, nitro or cyano. n Certain 1-(2-substituted-chromon-yloxy)-2-hydroxy-3-(substituted-phenoxy)propanes (Formula I), ##SPC1## n can be synthesized from intermediate bis-(substituted-phenoxy)propanes (Formula II), ##SPC2## n by condensation with diethyl oxalate in the presence of sodium ethoxide followed by cyclization with a mixture of glacial acetic acid and concentrated sulfuric or a mixture of concentrated hydrochloric acid and a lower alcohol containing up to 4 carbon atoms. n The bis-(substituted-phenoxy)propane intermediates (Formula II) are prepared by reacting a dihydroxyacetophenone (Formula III), ##SPC3## n with a (substituted-phenyl)glycidyl ether (Formula IV), ##SPC4## n in an organic solvent in the presence of a catalyst. n The 1-(2-substituted-chromon-yloxy)-2-hydroxy-3-(substituted-phenoxy)propanes (Formula I) are useful in the treatment of allergic conditions in mammals. The bis-(substituted-phenoxy)propanes (Formula II) are useful as intermediates in the synthesis of the latter compounds. Methods of preparing compounds having Formulae I and II are described. Methods of treating allergic conditions in mammals utilizing compounds of Formula I are also disclosed.

专利号:US-7211693-B2
优先权日:2002-08-02
标题:Preparation of lactic acid derivatives and their use
发明人：SELIFONOV SERGEY
权利人:AROMAGEN CORP
摘要:The present invention relates to preparing lactic acid derivatives that are useful as odorants and monomers for polymer synthesis.

专利号:US-12400388-B2
优先权日:2022-12-28
标 题:Unsupervised volumetric animation
发明人：CHAI MENGLEI; LEE HSIN-YING; MENAPACE WILLI; OLSZEWSKI KYLE; REN JIAN; SIAROHIN ALIAKSANDR; SKOROKHODOV IVAN; TULYAKOV SERGEY
权利人:CHAI MENGLEI; LEE HSIN YING; MENAPACE WILLI; OLSZEWSKI KYLE; REN JIAN; SIAROHIN ALIAKSANDR; SKOROKHODOV IVAN; TULYAKOV SERGEY; SNAP INC
摘要:Unsupervised volumetric 3D animation (UVA) of non-rigid deformable objects without annotations learns the 3D structure and dynamics of objects solely from single-view red/green/blue (RGB) videos and decomposes the single-view RGB videos into semantically meaningful parts that can be tracked and animated. Using a 3D autodecoder framework, paired with a keypoint estimator via a differentiable perspective-n-point (PnP) algorithm, the UVA model learns the underlying object 3D geometry and parts decomposition in an entirely unsupervised manner from still or video images. This allows the UVA model to perform 3D segmentation, 3D keypoint estimation, novel view synthesis, and animation. The UVA model can obtain animatable 3D objects from a single or a few images. The UVA method also features a space in which all objects are represented in their canonical, animation-ready form. Applications include the creation of lenses from images or videos for social media applications.

专利号:RU-2119482-C1
优先权日:1991-01-11
标 题:Acridine derivatives, method of synthesis, pharmaceutical composition and a method of treatment of patients with malignant tumors