📜1,2-二氢-2-氧代-4-氯-6-甲基吡啶-3-羧酸乙酯置于palladium On Activated Charcoal Sodium Hydroxide,氢气体系中,用 乙醇 作为反应溶剂,化学反应 1.75H,以88%的收率获得产物2-羟基-6-甲基吡啶-3-羧酸乙酯
参考文献:Aza Analogs Of Lucanthone: Synthesis And Antitumor And Bactericidal Properties
标题:Aza Analogs Of Lucanthone: Synthesis And Antitumor And Bactericidal Properties
摘要:Three Types Of Aza Analogues Of Lucanthone Were Synthesized For Evaluation As Antitumor Drugs. None Of The Compounds Was Found To Have Significant Cytotoxic Effects Either On Friend Tumor Cells Or On L1210 Leukemia Cells. However,One Of The Target Compounds,5,10-Dihydro-10-Oxo-1-[[3-(Diethylamino)Propyl]Amino]-3-Methylpyrido [4,3-B]Quinoline,Was Shown To Have Noticeable Antibiotic Properties.
DOI:10.1021/jm00363A022