专利号:US-5650393-A 优先权日:1992-08-06 标 题 :Amphiphilic compounds derived from amino acids or peptides, their methods of synthesis and their application as drug delivery systems 发明人:PAVIA ANDRE A; PUCCI BERNARD; RIESS JEAN G; ZARIF LEILA; GUEDJ CAMILLE 权利人:ALLIANCE PHARMA 摘要:Amphiphilic derivatives of amino acids or peptides are provided, comprising a polyhydroxylated hydrophilic part derived from a sugar, from a polyol, from an aminopolyol or from an oligosaccharide, and at least one hydrophobic part derived from a hydrocarbon, fluorocarbon, or a mixed fluorocarbon/hydrocarbon, saturated or unsaturated, having from 5 to 20 carbon atoms, the hydrophobic part(s) being linked to the hydrophilic part by a junction bearing an amino acid or a peptide.
专利号:CN-1384086-A 优先权日:2002-06-03 标 题:Photochemical synthesis of perfluoro bromoalkane or perfluoro alkane
专利号:US-5463082-A 优先权日:1993-07-08 标 题:Fluorous multiphase systems 发明人:HORVATH ISTVAN T; RABAI JOZSEF 权利人:EXXON RESEARCH ENGINEERING CO 摘要:Stoichiometric and catalytic chemical transformations may be carried out in solution using novel fluorous multiphase systems (FMS). The term 'fluorous' is defined as a carbon-fluorine bond rich organic molecule. The FMS consists of a fluorous phase containing a fluorous solvent, typically a fluorocarbon or a fluorohydrocarbon and a reagent or a catalyst containing a sufficient number of fluorous moieties to render it preferentially soluble in the fluorous solvent without impairing the ability of the catalyst or reagent to be effective in the reaction and while maintaining the reaction in a liquid or fluid phase. The nonfluorous solvent may be any suitable organic or nonorganic solvent(s) with limited or no solubility in the fluorous solvent that is effective for dissolving the reactant(s) and most desirably, for separating the resulting product(s). Typically, such solvents have a Hildebrand solubility parameter of at least about 18.0 MPa1/2. Appropriate fluorous moieties are linear, branched and carbocyclic fluorocarbon alkyl chains with high carbon numbers. FMS reagents and catalysts can be prepared by (1) fluorination (i.e., replacement of C--H bonds with fluorine); (2) fluorofunctionalization, e.g., the attachment of fluorous moieties to the reagents or catalysts; or (3) by total synthesis. The invention is useful in separations technology and in catalyst design and synthesis.
专利号:EP-0655069-A1 优先权日:1992-08-06 标 题 :Amphiphilic compounds derived from amino acids or peptides, their methods of synthesis and their application as drug delivery systems
专利号:CN-115181015-A 优先权日:2022-07-20 标 题:Synthesis method of tri-substituted perfluoroalkylated ketene compound
专利号:WO-9403468-A1 优先权日:1992-08-06 标题:Amphiphilic compounds derived from amino acids or peptides, their methods of synthesis and their application as drug delivery systems