CAS: 4170-24-5; 2-Chlorobutanoic Acid

相似化合物

29617-66-1 7474-05-7 32653-32-0

上下游产品

CAS号107-92-6 正丁酸 | CAS号2835-81-6 DL-2-氨基丁酸 | CAS号6111-61-1 ethyl(trichloro... | CAS号54235-90-4 ethyl-chloro-ma... | CAS号141-75-3 丁酰氯 | CAS号1492-24-6 L-2-氨基丁酸 | CAS号56-23-5 四氯化碳 | CAS号7791-25-5 磺酰氯 | CAS号94-36-0 过氧化苯甲酰 | CAS号600-15-7 DL-2-羟基丁酸 | CAS号187737-37-7 propene | CAS号625-38-7 乙烯基乙酸 | CAS号107-93-7 巴豆酸 | CAS号74-84-0 乙烷 | CAS号201230-82-2 carbon monoxide | CAS号123-38-6 丙醛 | CAS号129886-27-7 ethyl 2-(3-meth... | CAS号71-36-3 正丁醇

📜丁酸置于氯化亚砜,氯,四氯苯醌体系中,化学反应 5.0H,以92%的收率获得产物2-氯丁酸
参考文献:一种2-氯丁酸的制备方法
标题:一种2-氯丁酸的制备方法
摘要:本发明公开了一种2‑氯丁酸的制备方法,以丁酸为原料,以氯气为氯化剂,酰氯化试剂为催化剂,醌类化合物为自由基捕获剂,反应得到目标产物2‑氯丁酸.本发明工艺简单,选择性好,生产安全性高,成本低.

专利信息

专利号:US-5302520-A
优先权日:1990-09-25
标 题:Enzymatic synthesis of isotopically labeled carbohydrates
发明人：GOUX WARREN J
权利人:UNIV TEXAS
摘要:The present invention relates to a general method of enzymatic synthesis of isotopically labeled carbohydrates, sugars and nucleosides. Labeled citric acid cycle intermediates, amino acids and ribose mononucleotides may be rapidly and conveniently synthesized from labeled pyruvate, lactate or L-alanine. The method employs a novel nicotinamide dinucleotide regeneration system which permits use of low NADH levels. The method may be manipulated to allow labeling at a variety of carbon/hydrogen sites.

专利号:US-8541571-B2
优先权日:2008-03-03
标题:Homogeneous synthesis of cellulose ethers in ionic liquids
发明人：MOELLMANN EUGEN; HEINZE THOMAS; LIEBERT TIM; KOEHLER SARAH
权利人:MOELLMANN EUGEN; HEINZE THOMAS; LIEBERT TIM; KOEHLER SARAH; SE TYLOSE GMBH & CO KG
摘要:The invention is directed to a simple and new method for the homogeneous synthesis of cellulose ethers. Ionic liquids are not only used as solvent, but also as reaction media for the homogeneous etherification of cellulose. The dissolved cellulose is treated with the etherification agent in the absence of organic and/or inorganic bases and in the absence and/or in the presence of moderate amounts of water. The obtained cellulose ethers show new distributions of substitution on the polymer chain, resulting in new properties and applications.

专利号:US-5276151-A
优先权日:1990-02-01
标题:Method of synthesis of 1,3-dioxolane nucleosides
发明人：LIOTTA DENNIS C
权利人:UNIV EMORY
摘要:A synthesis of 1,3-dioxolane nucleosides that includes condensing a 2-0-protected-5-0-acylated-1,3-dioxolane with a purine or pyrimidine base in the presence of a titanium containing Lewis acid to provide predominately the desired (beta)-isomer in the C1'-position of a 1,3-dioxolane nucleoside. A process for the resolution of a racemic mixture of 1,3-dioxolane nucleoside enantiomers is also disclosed that includes the step of exposing the racemic mixture to an enzyme that preferentially catalyzes a reaction in one of the enantiomers.

专利号:WO-2019016826-A1
优先权日:2017-07-17
标 题:NOVEL 5- [4- (2-BIPHENYL-4-YL-2-OXOETHOXY) BENZYLIDENE] THIAZOLIDINE-2,4-DIONES, THEIR SYNTHESIS AND USES THEREOF
发明人：THAREJA SURESH; VERMA SANT KUMAR; JAIN AKHLESH KUMAR; BHARDWAJ TILAK RAJ
权利人:GURU GHASIDAS VISHWAVIDYALAYA A CENTRAL UNIV; INDIAN COUNCIL OF MEDICAL RES ICMR
摘要:Disclosed are novel 5-[4-(2-biphenyl-4-yl-2-oxo-ethoxy)-benzylidene]-thiazolidine-2,4-dione compounds of general formula (I), their pharmaceutically acceptable salts, solvates their synthesis and uses thereof, to pharmaceutical compositions containing compounds and to the use of such compounds and composition in medicines either alone or in combination with other compounds.

专利号:US-2006052577-A1
优先权日:2001-02-06
标题:Methods of synthesis of polymers and copolymers from natural products
发明人：SWIFT GRAHAM; WESTMORELAND DAVID G; HUGHES KATHLEEN
权利人:SWIFT GRAHAM; WESTMORELAND DAVID G; HUGHES KATHLEEN
摘要:Described are polymers and copolymers containing sorbitol, citric acid, starch, aspartic acid, succinic anhydride, adipic acid mixtures thereof, methods of their synthesis and their uses.

专利号:US-11999749-B2
优先权日:2021-06-30
标题 :Synthesis of a bis-mesylate salt of 4-amino-N-(1-((3-chloro-2-fluorophenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide and intermediates thereto
发明人：GOSSELIN FRANCIS; KOENIG STEFAN G; MERCADO-MARIN EDUARDO V; STUMPF ANDREAS; ZELL DANIEL; ZHANG HAIMING; BACHMANN STEPHAN; CARRERA DIANE E; DALZIEL MICHAEL E; GE YONGHUI; ZHANG JIE; BIGLER RAPHAEL; FINET LAURE ELIZABETH SIMONE; MONDIERE REGIS JEAN GEORGES; NAKAGAWA YUKI
权利人:GENENTECH INC; HOFFMANN LA ROCHE
摘要:A manufacturing process to a bis-mesylate salt 1b of the pan-RAF inhibitor 4-amino-n-(1-((3-chloro-2-fluorophenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide. The process features a number of efficient key reactions, including a robust and scalable Pd-catalyzed carbonylation reaction to generate thienopyrimidine 2 and a highly chemoselective Pt/V/C-catalyzed nitro group reduction to access penultimate intermediate 7. The final amide coupling of 7 and 2 was accomplished by a mild and safe protocol employing N,N,N′,N′-tetramethylchloroformamidinium hexafluorophosphate (TCFH) as the coupling reagent, to produce a 1:1 adduct of the freebase and THF. The adduct afforded compound 1b with excellent yield, purity, and form stability on a multikilogram production scale after reaction with MsOH and recrystallization. The methods are able to produce a compound having upwards of 95% purity.