CAS: 331752-47-7; Trans-4-[(R)-1-Aminoethyl]-N-(Pyridin-4-yl)Cyclohexanecarboxamide Dihydrochloride Hydrate
该化合物是Rho-相关蛋白质动脉(ROCK)的选择性抑制器,具体针对ROCK1和ROCK2,IC50分别~140 nM和~600 nM,其分子式为C14H21N3O2HCl,广泛用于研究Rho/ROCK信号路径.Y-27632表现出了高度的特性,有效地减少了压力纤维形成和体外细胞收缩.它在水和DMSO中可以溶解,便于实验应用.该化合物在细胞运动,细胞骨骼动态和集聚性调节学研究中特别有用.其精密的机制和再生化使得它成为药理学和细胞生物学研究的可靠工具.
- 英文名称Trans-4-[(R)-1-Aminoethyl]-N-(Pyridin-4-yl)Cyclohexanecarboxamide Dihydrochloride Hydrate
- 中文名称反-4-[(1R)-1-氨基乙基]-N-4-吡啶-环己甲酰胺盐酸盐-水合物
- IUPAC名称(1R,4r)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexane-1-carboxamide dihydrochloride hydrate
- 其它别名(R)-(+)-Trans-4-(1-Aminoethyl)-N-(4-Pyridyl)Cyclohexanecarboxamide Dihydrochloride Monohydrate; Trans-4-[(1R)-1-Aminoethyl]-N-4-Pyridinyl-Cyclohexanecarboxamide Dihydrochloride Monohydrate; Cyclohexanecarboxamide, 4-[(1R)-1-Aminoethyl]-N-4-Pyridinyl-, Dihydrochloride, Monohydrate, Trans- (9Ci); (R)-(+)-Trans-4-(1-Aminoethyl)-N-(4-Pyridyl)Cyclohexanecarboxamide Monohydrate Dihydrochloride
- CAS编号331752-47-7
- MFCD编号:MFCD06245589
- EINECS号:621-782-5
- 分子式:C14H25Cl2N3O2分子量:338.28
- 产品CID: 1325752
- 同类组份化合物CAS331752-47-7 (HCl hydrate)129830-38-2 (2HCl)146986-50-7 (free base)138381-45-0 (racemate HCl)310898-86-3 (recamte free base)
- 产品分类医药中间体 → 杂环化合物中间体 → 吡啶类化合物 → 乙基吡啶
物理性质
- 熔点180-230 °C
- 沸点180-230 °C
- PSA:77.24
- LogP:4.4867
- 溶解性Acetonitrile (Very Slightly), DMSO (Slightly), Methanol (Slightly), Water (Sligh
- 敏感性Hygroscopic; Light Sensitive;
- 外观形态固体-粉末
- 储存条件2-8°C
- 产品应用该化合物是ROCK-I和ROCK-II口服活性,具有ATP竞争力的抑制剂,基值分别为220纳米和300纳米;它能减少人类心脏干细胞中因毒菌素引起的聚变;它也能抑制老鼠前列腺干/发源体细胞中分离引起的聚虫病;它通过上皮细胞-脑细胞过渡式的调节,促进将人类诱导的多能干干细胞(HIPSCS)有选择地区分为中位性动物系系.
MSDS等安全信息
欧盟法规
C&L通报合成工艺路线路线简述
海关参考信息
- 2912110000-甲醛
2912120000-乙醛
2933310010-吡啶
2924199090-其他无环酰胺 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Tsuboi M, Fujio M, Chang Q, Bian H, Wakasugi M, Liu Y, Hibi H. Rho-associated coiled-coil-containing protein kinase inhibitor Y-27632 promotes distraction osteogenesis healing by activating both osteoblasts and osteoclasts. Nagoya J Med Sci. 2025 Nov;87(4):719-729. doi: 10.18999/nagjms.87.4.719.
2: Wu W, Liu H, Zhang J, Dong Y, Peng M, Zhu Q, Zhang Y, Zhao W, Zhang L, Ren Y, Liu J, Li B, Li W, Hu Y, Duan J, Gou M. 3D printing of Y-27632 enhanced elastic hydrogel conduits for peripheral nerve repair. Biomater Adv. 2025 Dec 26;182:214679. doi: 10.1016/j.bioadv.2025.214679. Epub ahead of print.
263:110818. doi: 10.1016/j.exer.2025.110818. Epub 2025 Dec 18.
合成参考文献
参考文献:10.1007/s10735-010-9253-y
摘要:Jeanes A, Smutny M, Leerberg JM, Yap AS. Phosphatidylinositol 3′-kinase signalling supports cell height in established epithelial monolayers. Journal of Molecular Histology. 2009 Oct;40(5-6):395–405. doi: 10.1007/s10735-010-9253-y.
参考文献:10.1007/s11357-011-9285-6
摘要:Macias B, Gomez-Pinilla PJ, Camello-Almaraz C, Pascua P, Tresguerres JA, Camello PJ, Pozo MJ. Aging impairs Ca2+ sensitization pathways in gallbladder smooth muscle. GeroScience. 2011 Jul 12;34(4):881–93. doi: 10.1007/s11357-011-9285-6.
参考文献:10.1007/s00535-005-1688-7
摘要:Takahashi A, Tomomasa T, Kaneko H, Hatori R, Ishige T, Suzuki M, Mochiki E, Morikawa A, Kuwano H. In vivo recording of colonic motility in conscious rats with deficiency of interstitial cells of Cajal, with special reference to the effects of nitric oxide on colonic motility. J Gastroenterol. 2005 Nov;40(11):1043–8. doi: 10.1007/s00535-005-1688-7.
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