CAS: 3306-62-5; 2-Aminobenzenesulfonamide

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邻氯苯磺酰胺置于ammonium Carbonate,Ammonium Hydroxide,Copper(II) Sulfate体系中,化学反应生成 邻氨基苯磺酰胺
参考文献:Hepatitis C Ns5B Polymerase Inhibitors: 4,4-Dialkyl-1-Hydroxy-3-Oxo-3,4-Dihydronaphthalene-3-Yl Benzothiadiazine Derivatives
标题:Hepatitis C Ns5B Polymerase Inhibitors: 4,4-Dialkyl-1-Hydroxy-3-Oxo-3,4-Dihydronaphthalene-3-Yl Benzothiadiazine Derivatives
摘要:4,4-Dialkyl-1-Hydroxy-3-Oxo-3.4-Dihydronaphthalene-3-Yl Benzothiadiazine Derivatives Were Synthesized And Evaluated As Inhibitors Of Genotypes 1A And 1B Hcv Ns5B Polymerase. A Number Of These Compounds Exhibited Potent Activity Against Genotypes 1A And 1B Hcv Polymerase In Both Enzymatic And Cell Culture Activities. A Representative Compound Also Showed Favorable Pharmacokinetics In The Rat. (C) 2008 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmcl.2008.06.043

专利信息

专利号:US-2022315528-A1
优先权日:2019-08-21
标题:Inhibitors of phospholipid synthesis and methods of use
发明人：GOUW ARVIN; SCHOW STEVEN R; GREENHOUSE ROBERT J; KLINE TONI; FELSHER DEAN W
权利人:UNIV LELAND STANFORD JUNIOR
摘要:Inhibitors of Glycerol 3-Phosphate Acyltransferase (GPAT) are provided; and methods of use in the treatment of cancer; and treatment of conditions relating to metabolic syndrome, hyperlipidemia, infection and inflammation.

专利号:US-5633400-A
优先权日:1993-01-06
标 题:Process for the preparation of biphenyl derivatives
发明人：WAGNER ADALBERT; BHATNAGAR NEERJA; BUENDIA JEAN; GRIFFOUL CHRISTINE
权利人:HOECHST AG
摘要:The invention relates to a process for the preparation of a compound of the formula (I) ##STR1## in which X is an optionally protected formyl group and n R is a group which is itself inert to the reaction conditions of the synthesis, n which comprises reacting a compound of the formula (II) ##STR2## where X is as defined above, with a substituted phenyl-halogen compound of the formula (III) ##STR3## where the substituent Hal is a halogen group and R is as defined above.

专利号:WO-2007002173-A1
优先权日:2005-06-22
标 题:Hiv-1 protease inhibitors, and methods of making and using them
发明人：RANA TARIQ M; ALI AKBAR; CAO HONG; SAI KIRAN KUMAR REDDY GA; ANJUM SAIMA GHAFOOR
权利人:UNIV MASSACHUSETTS; RANA TARIQ M; ALI AKBAR; CAO HONG; SAI KIRAN KUMAR REDDY GA; ANJUM SAIMA GHAFOOR
摘要:One aspect of the invention relates to the design, synthesis and biological activity of novel HIV-1 protease inhibitors incorporating N-phenyloxazolidine-5-carboxamides into the (hydroxyethylamino)sulfonamide scaffold as P2 ligands. For example, the present invention relates to inhibitors with variations at the P2 phenyloxazolidine and the P2' phenylsulfonamide moieties. Remarkably, compounds with an (S)-enantiomer of substituted phenyloxazolidines at P2 show highly potent inhibitory activities against wild-type HIV-1 protease. In certain embodiments, the inhibitors of the invention have Ki values in low picomolar (pM) range. In certain embodiments, the inhibitors of the invention were shown to be active against a variety of multi-drug resistant (MDR) HIV-1 proteases, each representing different paradigm of drug resistance.

专利号:CN-107033104-B
优先权日:2017-05-16
标题 :A kind of method of asymmetric synthesis of chirality thiazides compounds

专利号:CN-117843549-A
优先权日:2024-01-04
标 题:Method for asymmetric catalytic synthesis of 3,3-disubstituted chiral indole ketone derivatives

专利号:US-11932614-B2
优先权日:2019-12-29
标题 :Method for preparing diazoxide
发明人：QIAO CHUNHUA; XU YIWEN
权利人:UNIV SOOCHOW
摘要:A method for preparing diazoxide includes reacting o-aminobenzenesulfonamide with N-chlorosuccinimide in a chlorine solvent to obtain 2-amino-5-chlorobenzenesulfonamide, mixing the 2-amino-5-chlorobenzenesulfonamide, an imidazole salt and an amide solvent, then heating same for reaction so as to obtain diazoxide; or mixing o-aminobenzenesulfonamide, an imidazole salt and an amide solvent, then heating same for reaction to obtain a compound IV; then reacting the compound IV with N-chlorosuccinimide in a chlorine solvent to obtain diazoxide. The application of imidazole hydrochloride as a catalyst in preparing diazoxide is also disclosed. The present invention avoids the use of highly corrosive and toxic chlorosulfonyl isocyanate, a strong acid (sulfuric acid), and a high reaction temperature (240-250° C.), and the reaction steps are short; the total yield of the two steps is more than 90%, and compared with publicly disclosed preparation methods for diazoxide, the synthesis route overcomes numerous shortcomings, thus being more suitable for industrial production.