CAS: 306-52-5; Triclofos

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CAS号115-20-8 2,2,2-三氯乙醇 | CAS号67154-52-3 2-(2,2,2-trichl... | CAS号10026-13-8 五氯化磷 | CAS号7719-12-2 三氯化磷

📜2,2,2-三氯乙醇置于亚磷酸,三乙胺,碘体系中,化学反应 0.33H,反应生成 磷酸三氯乙酯
参考文献:设计的螺旋-环-螺旋基序肽催化尿苷 3'-2,2,2-三氯乙基磷酸酯裂解
标题:设计的螺旋-环-螺旋基序肽催化尿苷 3'-2,2,2-三氯乙基磷酸酯裂解
摘要:折叠成螺旋-环-螺旋基序并二聚化形成四螺旋束的 42 个残基肽已被设计用于催化磷酸二酯的水解.折叠催化剂表面的活性位点由两个组氨酸和四个精氨酸残基组成,具有提供一般酸,一般碱和/或亲核催化以及过渡态稳定的能力.尿苷 3'-2,2,2 三氯乙基磷酸酯 (2) 是 Rna 的模拟物,离去基团 Pka 为 12.3.它的水解在能量上不如带有对硝基苯基离去基团的常用模型底物有利,因此是设计能够切割 Rna 的催化剂的更现实模型.多肽催化剂在 Ph 7.0 下水解 2 的二级速率常数为 418 X 10(-6) M-1 S-1,咪唑催化反应的产物为 1.66 X 10(-6) M-1 S-1.ph 依赖性表明催化是由于残基的非质子化形式,Pka 约为 5.3,观测到的动力学溶剂同位素效应为 1.9,表明在过渡态存在显着的氢键,与一般酸碱催化一致. 速率常数比 K2(Pep)/k2(Im) 为 252
DOI:10.1021/ja075478I

专利信息

专利号:US-4348536-A
优先权日:1975-05-28
标 题 :Odorless catalysts for the synthesis of polyurethanes
发明人：BLAHAK JOHANNES; HUEBNER HANS; KOSTER JOHANNES; MEINERS HANS J; THOMAS HEINZ
权利人:BAYER AG
摘要:The instant invention is directed to novel compounds and the use thereof in producing polyurethane resins. The compounds generally correspond to the following formula: wherein n is an integer of from 1 to 5, R is a C1-C5 alkyl group Y is a C1-C5 alkyl group or a and Z is a where n=0 or 1, X is -O- or and R' is an aliphatic group having from 1 to 15 carbon atoms and may contain ester, ether, or amide groups or tertiary nitrogen and, when m=0, R' may be a hydrogen atom.

专利号:US-4293680-A
优先权日:1979-08-08
标 题:Process for the production of diisocyanato toluene mixtures having an increased content of 2,6-diisocyanato toluene, and the use thereof as synthesis components in the production of polyurethane elastomers
发明人：MAZANEK JAN; NUELLER HANNS P
权利人:BAYER AG
摘要:The instant invention is directed to a process for the production of diisocyanate mixtures of 2,4-diisocyanato toluene and 2,6-diisocyanato toluene, having from 36 to 90% by weight, based on the total mixture, of 2,6-diisocyanato toluene, comprising: trimerizing some of the isocyanate groups of a diisocyanate mixture of 2,4-diisocyanato toluene and 2,6-diisocyanato toluene, having a maximum content of 2,6-diisocyanato toluene of 35% by weight based on the total mixture and isolating from the reaction mixture which is thus obtained, a diisocyanate mixture having an increased content of 2,6-diisocyanato toluene. The invention is also directed to the use of these mixtures as synthesis components in the production of polyurethane elastomers.

专利号:US-8697888-B2
优先权日:2012-01-06
标题 :Substituted (1-(methylsulfonyl)azetidin-3-yl)(heterocycloalkyl)methanone analogs as antagonists of muscarinic acetylcholine M1 receptors
发明人：LINDSLEY CRAIG W; CONN P JEFFREY; WOOD MICHAEL R; MELANCON BRUCE J; CHEUNG YIU-YIN
权利人:UNIV VANDERBILT
摘要:In one aspect, the invention relates to substituted (1-(methylsulfonyl)azetidin-3-yl)(heterocycloalkyl)methanone analogs, derivatives thereof, and related compounds, which are useful as antagonists of the muscarinic acetylcholine receptor M 1 (mAChR M 1 ); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-9056875-B2
优先权日:2012-08-31
标 题 :Substituted pyrazolo[3′,4′:4,5]thieno[2,3-C]pyridazin-3-amine analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M4
发明人：LINDSLEY CRAIG W; CONN P JEFFREY; WOOD MICHAEL R; SALOVICH JAMES M
权利人:UNIV VANDERBILT
摘要:In one aspect, the invention relates to substituted pyrazolo[3′,4′:4,5]thieno[2,3-c]pyridazine-3-amine analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M 4 (mAChR M 4 ); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-9073935-B2
优先权日:2011-11-11
标 题:Substituted benzylspiroindolin-2-one analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M1
发明人：LINDSLEY CRAIG W; CONN P JEFFREY; WOOD MICHAEL R; HOPKINS COREY R; MELANCON BRUCE J; POSLUSNEY MICHAEL S
权利人:UNIV VANDERBILT
摘要:In one aspect, the invention relates to substituted benzylspiroindolin-2-one analogs compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M 1 (mAChR M 1 ); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-7799829-B2
优先权日:2006-07-28
标 题 :Acyloxyalkyl carbamate prodrugs of α-amino acids, methods of synthesis and use
发明人：DAI XUEDONG; GANGAKHEDKAR ARCHANA; XIANG JIA-NING; GALLOP MARK A
权利人:XENOPORT INC
摘要:Acyloxyalkyl carbamate prodrugs of α-amino acids, pharmaceutical compositions thereof, methods of making acyloxyalkyl carbamate prodrugs of α-amino acids and methods of using acyloxyalkyl carbamate prodrugs of α-amino acids, and pharmaceutical compositions thereof to treat a disease are disclosed. Acyloxyalkyl carbamate prodrugs of α-amino acids suitable for oral administration using sustained release dosage forms are also disclosed.