CAS: 23779-99-9; 2,3-Dihydroxypropyl 2-((8-(Trifluoromethyl)Quinolin-4-yl)Amino)Benzoate

上下游产品

4-chloro-8-(trifluoromethyl)quinoline α-Glyceryl Anthranilate isatoic anhydride N-phenylpicolinamide2-oxoethyl 2-{[8-(trifluoromethyl)quinolin-4-yl]amino}benzoate 2-{[8-(trifluoromethyl)quinolin-4-yl]amino}benzohydrazide

📜N-苯基异喹啉-1-甲酰胺置于盐酸,叔丁基过氧化氢,Copper Diacetate,三氯氧磷体系中,用 二苯醚,乙醇,水,乙腈 用作溶剂,化学反应 26.42H,反应生成夫洛非宁
参考文献:协调活化策略诱导的苯胺选择性ch三氟甲基化
标题:协调活化策略诱导的苯胺选择性ch三氟甲基化
摘要:通过协调活化策略,开发了一种简单的合成2-(三氟甲基)苯胺衍生物的方案.反应显示出非常好的反应性,并以中等至非常好的收率获得目标产物.令人愉悦的是,可以以优异的收率回收指导基团.此外,该策略允许有效地获得氟他芬宁的合成.有人提出单电子转移机制负责该三氟甲基化反应.
Doi:10.1002/cctc.201701596

专利信息

专利号:US-9051302-B2
优先权日:2008-01-15
标 题 :Synthesis of resorcylic acid lactones useful as therapeutic agents
发明人：WINSSINGER NICOLAS; BARLUENGA SOFIA; KARPLUS MARTIN
权利人:WINSSINGER NICOLAS; BARLUENGA SOFIA; KARPLUS MARTIN; UNIV STRASBOURG
摘要:Disclosed are macrocyclic compounds of formulae I, I′, II, II′, III, III′, IV, and V, which are analogs of the pochonin resorcylic acid lactones, pharmaceutical compositions comprising the compounds, and methods and uses comprising the compounds for the treatment of diseases mediated by kinases and Heat Shock Protein 90 HSP90.

专利号:US-2024287041-A1
优先权日:2021-05-20
标题 :Methods of synthesis of heteroaryl derivatives of triazolyl acrylamides and crystalline forms
发明人：BALOGLU ERKAN; AUSTAD BRIAN C; ROE DAVID G; KEDUC ANDREW; GOTTSCHLING STEPHEN EDMUND; HECKER EVAN
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The present invention relates to a method of preparing a compound represented by structural formula (VII), comprising reacting a compound represented by structural formula (II), with a compound represented by structural formula (III), in a solvent, in the presence of a Pd catalyst and one or more inorganic bases under conditions suitable to prepare a compound represented by structural formula (VII): The values and example values of the variables in structural formulas (VII), (II), and (III) are defined herein. The present invention also relates to crystalline Forms I and II of the compound represented by Structural Formula (VII), the use of the crystalline Forms in treating disease or disorders associated with CRM1 and method of preparing the crystalline Forms.

专利号:US-5792753-A
优先权日:1991-07-03
标 题:Compositions comprising hyaluronic acid and prostaglandin-synthesis-inhibiting drugs
发明人：FALK RUDOLF EDGAR; ASCULAI SAMUEL SIMON
权利人:HYAL PHARMA CORP
摘要:A topically administrable pharmaceutical composition is disclosed which comprises a therapeutically effective amount of a drug which inhibits prostaglandin synthesis, and an amount of a form of hyaluronic acid sufficient to transport the composition through the skin into the epidermis or dermis where the composition remains until discharged via the lymphatic system, wherein n (a) the drug is 1-5% by weight of the composition, and n (b) the form of hyaluronic acid is 1-3% by weight of the composition, has a molecular weight greater than about 150,000 daltons and less than 750,000 daltons, and is selected from the group consisting of hyaluronic acid and salts thereof.

专利号:AU-2022276509-A1
优先权日:2021-05-20
标题:Methods of synthesis of heteroaryl derivatives of triazolyl acrylamides and crystalline forms

专利号:US-9994558-B2
优先权日:2013-09-20
标题 :Multicyclic compounds and methods of using same
发明人：BALOGLU ERKAN; SHACHAM SHARON; SENAPEDIS WILLIAM; MCCAULEY DILARA; LANDESMAN YOSEF; GOLAN GALI; KALID ORI; SHECHTER SHARON
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to compounds represented by Structural Formula I: or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders (e.g., PAK-mediated, for example, PAK4-mediated, diseases and disorders).

专利号:US-4778805-A
优先权日:1987-06-18
标题:4,7-benzofurandione derivatives useful as inhibitors of leukotriene synthesis
发明人：ADAMS JULIAN; GUINDON YVAN; BELANGER PATRICE C; BELLEY MICHEL L; ROKACH JOSHUA
权利人:MERCK FROSST CANADA
摘要:4,7-Benzofurandione derivatives of Formula I, pharmaceutical compositions, and methods of treatment are disclosed. These compounds are useful as inhibitors of mammalian leukotriene biosynthesis. As such, these compounds are useful therapeutic agents for treating allergic conditions, asthma, cardiovascular disorders, inflammation, psoriasis and allergic conjunctivitis. The compounds are also useful as analgesics and as cytoprotective agents. Also disclosed are novel intermediates useful for the preparation of the 4,7-benzofurandiones of this invention. ##STR1##