专利号:US-4469701-A 优先权日:1983-06-23 标题 :Pyrrolid-3-en-2-ones and pharmaceutical methods of use thereof 发明人:DEBAUN JACK R; PALLOS FERENC M; MATSUMOTO KENT E; ROSS JOHN H 权利人:STAUFFER CHEMICAL CO 摘要:Novel compounds having the structural formula ##STR1## wherein R 1 and R 2 are independently selected from the group consisting of hydrogen, halo, alkyl, haloalkyl, thioalkyl, thiohaloalkyl, alkoxy, cyano and nitro are provided. The compounds have various pharmacological effects, including cardiotropic, hypoglycemic, hypocholesterolemic and/or antiulcerative effects in mammals. Methods of achieving these various pharmacological effects in mammals by administering the compounds thereto are provided. Pharmaceutical compositions and formulations including the compounds are provided along with methods of synthesis of the novel compounds.
专利号:US-9550000-B2 优先权日:2011-09-09 标题 :Compositions, methods, and systems for the synthesis and use of imaging agents 发明人:ROBINSON SIMON P; YU MING 权利人:ROBINSON SIMON P; YU MING; LANTHEUS MEDICAL IMAGING INC 摘要:The present invention relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, the imaging agent is enriched in 18 F. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs. In some embodiments, methods and compositions for assessing perfusion and innervation mismatch in a portion of a subject are provided.
专利号:US-10814013-B2 优先权日:2006-10-05 标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
专利号:AU-2007308022-A2 优先权日:2006-10-05 标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
专利号:AU-2007308022-A1 优先权日:2006-10-05 标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
专利号:AU-2007308022-B2 优先权日:2006-10-05 标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
1: Anzawa R, Ishikawa S, Tanaka Y, Okazaki F, Mochizuki S. Increased AAI mode pacing threshold after termination of atrial fibrillation by acute administration of disopyramide phosphate. Europace. 2006 May;8(5):345-8. Japanese. 12: Katoh T, Sasaki Y, Tsuda T. [Effects of disopyramide phosphate in repetitive paroxysmal ventricular tachycardia]. Kokyu To Junkan. 1982 Sep;30(9):959-64. Japanese. Japanese. 18: Sinatra ST, Landry AB Jr, Galle JS, Amato J. Cardiogenic shock associated with disopyramide phosphate. JAMA. 1980 Mar 21;243(11):1132.
合成参考文献
摘要:Nippon Naika Gakkai Zasshi. Journal of the Japanese Society of Internal Medicine., 72(1177), 1983 [] 摘要:Journal of Analytical Toxicology., 6(255), 1982 [] 摘要:Medical Journal of Australia., 2(335), 1978