CAS: 2028-63-9; 3-Butyn-2-Ol

上下游产品

Propargylic aldehyde methylmagnesium bromide 3-bromo-3-buten-2-ol ethynyldimagnesium dibromide 3-(1'-pyrrolidinyl)-2-butanone 4-isobutylamino-but-3-en-2-one 1,4-di-penta-1,3-diynyl-benzene 1-diethylamino-pent-2-yn-4-ol

3-丁炔-2-酮置于sodium Tetrahydroborate体系中,用 乙醇 用作溶剂,化学反应 1.0H,反应生成3-丁炔-2-醇
参考文献:两种氧化还原酶对多种炔丙醇的两种对映异构体的对映选择性合成
标题:两种氧化还原酶对多种炔丙醇的两种对映异构体的对映选择性合成
摘要:氧化还原酶短乳杆菌醇脱氢酶 (Lbadh) 和近平滑念珠菌羰基还原酶 (Cpcr) 是还原酮以提供对映体纯 Sec 的合适催化剂.醇类.广泛的炔酮(1,3 和 5)可用作底物,并以非常好的收率和优异的对映体过量获得相应的炔丙醇(2,4 和 6).通过改变取代基的空间需求,可以调整 Ee 值,甚至可以改变产品的构型.
Doi:10.1002/1099-0690(200111)2001:22<4181::Aid-Ejoc4181>3.0.Co;2-T

专利信息

专利号:US-5849936-A
优先权日:1995-03-15
标题:Method for the synthesis of bis-tetrahydrofuranyl annonaceous acetogenins
发明人：HOYE THOMAS R; TAN LUSHI
权利人:UNIVERISTY OF MINNESOTA
摘要:A method for the synthesis of bis-tetrahydrofranyl Annonaceous acetogenins, including the natural products and analogs thereof, is provided which proceeds by the Pd-mediated coupling of a bis-tetrahydrofuranyl-subunit comprising a terminal alkyne, with a (C4)-hydroxybutenolide subunit comprising a terminal vinyl iodide, followed by selective reduction of the resulting enyne.

专利号:US-8273790-B2
优先权日:2005-01-14
标 题:Exo-selective synthesis of himbacine analogs
发明人：THIRUVENGADAM TIRUVETTIPURAM K; SUDHAKAR ANANTHA; LIM NGIAP KIE; KWOK DAW-IONG; WU GEORGE G; WANG TAO; HUANG MINGSHENG; GREEN MICHAEL D
权利人:THIRUVENGADAM TIRUVETTIPURAM K; SUDHAKAR ANANTHA; LIM NGIAP KIE; KWOK DAW-IONG; WU GEORGE G; WANG TAO; HUANG MINGSHENG; GREEN MICHAEL D; SCHERING CORP
摘要:This application discloses a novel process for the synthesis of himbacine analogs, as well as the compounds produced thereby. The synthesis proceeds by alternative routes including the cyclic ketal amide route, the chiral carbamate amide route, and the chiral carbamate ester route. The compounds produced thereby are useful as thrombin receptor antagonists. The chemistry disclosed herein is exemplified in the following synthesis sequence:

专利号:US-5739358-A
优先权日:1996-10-03
标题:Synthesis of acetogenins
发明人：HOYE THOMAS R; YE ZHIXIONG
权利人:UNIV MINNESOTA
摘要:A method for the synthesis of bis-tetrahydrofuranyl annonaceous acetogenins, including the natural products and analogs thereof, is provided which proceeds by the Pd-mediated coupling of a bis-tetrahydrofuranyl-subunit comprising a terminal alkyne, with a (C4)-hydroxybutenolide subunit comprising a terminal vinyl iodide, followed by selective reduction of the resulting enzyme.

专利号:US-6384228-B2
优先权日:1998-05-26
标题 :Method for synthesis of halopyridyl-azacyclopentane derivative and intermediate thereof
发明人：NODE MANABU; NAKAMURA DAISAKU; FUJIWARA TOSHIO; ICHIHASHI SHOGO
权利人:NIHON MEDIPHYSICS CO LTD
摘要:The present invention relates to a method for synthesis of an optically active halopyridyl-azacyclo-pentane derivative and the intermediate thereof which comprises preparing an optically active allene-1,3-dicarboxylic acid ester derivative from an optically active acetonedicarboxylic acid ester derivative and then proceeding through a 7-azabicyclo[2.2.1]heptane derivative to obtain the objective product.

专利号:US-9267213-B1
优先权日:2005-03-25
标题:Electrochemical deblocking solution for electrochemical oligomer synthesis on an electrode array
发明人：MAURER KARL; COOPER JOHN J
权利人:CUSTOMARRAY INC
摘要:There is disclosed an electrochemical deblocking solution for use on an electrode microarray. There is further disclosed a method for electrochemical synthesis on an electrode array using the electrochemical deblocking solution. The solution and method are for removing acid-labile protecting groups for synthesis of oligonucleotides, peptides, small molecules, or polymers on a microarray of electrodes while substantially improving isolation of deblocking to active electrodes. The method comprises applying a voltage or a current to at least one electrode of an array of electrodes. The array of electrodes is covered by the electrochemical deblocking solution.

专利号:EP-1641729-B1
优先权日:2003-07-09
标题:Use of functionalized onium salts as a soluble support for organic synthesis
发明人：VAULTIER MICHEL; GMOUH SAID; HASSINE FATIMA
权利人:CENTRE NAT RECH SCIENT; UNIV RENNES
摘要:The invention relates to the use of a onium salt functionalized by at least one organic function, as a soluble support, in the presence of at least one organic solvent, for organic synthesis of a molecule, in a homogenous phase, by at least one transformation of said organic function. The onium salt enables the synthesized molecule to be released. The onium salt is present in liquid or solid form at room temperature and corresponds to formula A₁⁺, X₁^-, wherein A₁⁺ represents a cation and X₁^- represents an anion.