CAS: 1926-49-4; Clometocillin

该化合物是青霉素类的半合成抗生素,专门设计用于防治细菌感染,其特点是其针对各种青蒿素阳性细菌和一些青蒿色细菌的广泛光谱活动,其化合物具有乙状乳酶环,这对抗菌特性至关重要,因为它抑制了细菌细胞壁合成.氯米特西林通常通过注射施用,并因其稳定性而闻名于某些乙状显微藻,细菌产生的酶,可以使许多青蒿毒素不活化.其药用植物的特征包括体内快速吸收和分布,其半衰期相对较短,需要多剂量才能得到有效治疗.常见副作用可能包括过敏反应,胃肠扰动以及与其他药物的潜在互动.由于抗生菌的出现,使用氯米妥西林和类似的抗生酶往往受到感应测试的引导,以确保对目标病原体的功效.总体而言,氯米狄氏素是防止细菌感染的重要工具,尽管必须认真监测其使用以降低抗力.

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MSDS等安全信息

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    专利信息


    专利号:US-2025002508-A1
    优先权日:2020-05-05
    标题 :Boronic acid derivatives and synthesis, polymorphic forms, and therapeutic uses thereof
    发明人:HECKER SCOTT J; BOYER SERGE HENRI; BIO MATTHEW M; FANG YUANQING; GONZALES DE CASTRO ANGELA; LEFORT LAURENT; ZHU ZUOLIN; LINDER THOMAS
    权利人:QPEX BIOPHARMA INC
    摘要:Disclosed herein are antimicrobial compounds, polymorphic forms, compositions, pharmaceutical compositions, the method of use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents, for example, β-lactamase inhibitors (BLIs).

    专利号:US-2015150995-A1
    优先权日:2012-08-09
    标题:Conjugated anti-microbial compounds and conjugated anti-cancer compounds and uses thereof
    发明人:TAFT III KARL MILTON; ENGELKING JARRED ROY
    权利人:PONO CORP
    摘要:Disclosed herein are synthesis methods for generation of conjugated anti-microbial compounds and conjugated anti-cancer compounds. Several embodiments, related to the uses of such compounds in the treatment of infections, in particular those caused by drug-resistant bacteria. Some embodiments relate to targeting cancer based on the metabolic signature of tumor cells.

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    主要参考文献


    1: KAPLAN M. [USE IN CHILDREN OF A NEW ORAL PENICILLIN: CLOMETOCILLIN]. Gaz Med Fr. 1964 Apr 25;71:1621-5. French.

    合成参考文献


    参考文献:10.1007/s10006-020-00896-x
    摘要:Vandeplas C, Politis C, Van Eldere J, Hauben E. Cervicofacial actinomycosis following third molar removal: case-series and review. Oral Maxillofac Surg. 2021 Mar;25(1):119–25. doi: 10.1007/s10006-020-00896-x.
    摘要:S6 | ITNANTIBIOTIC | Antibiotic List from the ITN MSCA ANSWER | DOI:10.5281/zenodo.2621956
    摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2003).
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