CAS: 170916-55-9; 1-(4-((3,4-Dichlorobenzyl)Oxy)Phenyl)Ethanone

相似化合物

66742-56-1 61035-74-3 61292-27-1

上下游产品

3,4-Dichlorophenylmethyl chloride 4-Hydroxyacetophenone

📜3,4-二氯氯苄,对羟基苯乙酮置于potassium Carbonate体系中,用 N,N-二甲基甲酰胺 用作溶剂,以195 G的收率获得1-(4-[(3,4-二氯苄基)氧基]苯基)-1-乙酮
参考文献:苯并二恶英类药物中间体高温形成的连续流动条件:早期物料输送的快速放大
标题:苯并二恶英类药物中间体高温形成的连续流动条件:早期物料输送的快速放大
摘要:我们开发了一种连续流方法,可以快速放大对映体富集的苯并二恶烷中间体.我们建议反应通过分子内的s N Ar环化进行.有趣的是,传统的s N Ar条件导致形成杂质.当起始材料2用极性非质子传递溶剂中的碱碱处理,观测到不期望的产物区域异构体.通过使用极性较小的溶剂,有机碱和高温,可以抑制该区域异构体杂质的形成.通过采用连续流技术,可以将这些高温条件按比例放大以生产540 G所需的中间体.连续流动反应器可实现快速的热平衡,通过减少产品暴露于高温的时间,将有问题的产品分解降至最低.
Doi:10.1021/acs.Oprd.9B00499

专利信息

专利号:US-6005103-A
优先权日:1993-11-19
标题 :Pyrone derivatives as protease inhibitors and antiviral agents
发明人：DOMAGALA JOHN MICHAEL; LUNNEY ELIZABETH; PARA KIMBERLY SUZANNE; PRASAD JOSYULA VENKATA NAGENDR; TAIT BRADLEY DEAN
权利人:WARNER LAMBERT CO
摘要:The present invention relates to novel tri- and tetrasubstituted pyrones and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The pyrone derivatives are useful in the development of therapies for the treatment of bacterial and viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized pyrones and of related structures.

专利号:EP-0729465-B1
优先权日:1993-11-19
标 题:Pyrone derivatives as protease inhibitors and antiviral agents
发明人：DOMAGALA JOHN MICHAEL; LUNNEY ELIZABETH; PARA KIMBERLY SUZANNE; PRASAD JOSYULA VENKATA NAGENDR; TAIT BRADLEY DEAN
权利人:PARKE DAVIS & CO
摘要:The present invention relates to novel tri- and tetrasubstituted pyrones and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The pyrone derivatives are useful in the development of therapies for the treatment of bacterial and viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized pyrones and of related structures.