CAS: 16004-15-2; 1-(Bromomethyl)-4-Iodobenzene

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49617-83-6 40400-13-3 624-31-7

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CAS号624-31-7 对碘甲苯 | CAS号18282-51-4 4-碘苄醇 | CAS号34241-39-9 2-(2-cyanopropa... | CAS号619-58-9 对碘苯甲酸 | CAS号106-49-0 对甲苯胺 | CAS号506-68-3 溴化氰 | CAS号140621-52-9 1-(4-iodophenyl... | CAS号34633-09-5 4-碘肉桂酸 | CAS号39959-59-6 4-碘苄胺 | CAS号51628-12-7 4-碘苯乙腈 | CAS号189132-01-2 1,1-二甲基乙基N-[(4-... | CAS号25100-55-4 2-[(4-iodopheny... | CAS号3058-39-7 4-碘苯甲腈 | CAS号644-08-6 4-甲基联苯 | CAS号3218-36-8 4-联苯甲醛 | CAS号15164-44-0 4-碘苯甲醛 | CAS号858676-60-5 1-(4-碘苄基)吡咯烷

4-碘甲苯置于n-溴代丁二酰亚胺(Nbs),过氧化苯甲酰体系中,用 四氯化碳 用作溶剂,化学反应 18.0H,以61%的收率获得4-碘苄基溴
参考文献:镍/ Nn2夹配体配合物催化烷基锌试剂与溴化苄的羰基化偶联
标题:镍/ Nn2夹配体配合物催化烷基锌试剂与溴化苄的羰基化偶联
摘要:描述了一种高效的催化方案,用于三组分组装苄基溴,一氧化碳和烷基锌试剂,得到苄基烷基酮,它代表了两个sp 3-碳片段的第一个镍催化的羰基化偶联.该方法依赖于将镍与nn 2型钳形配位体配合使用,以及从固体前体中控制释放co气体的方法,适用于一系列苄基溴化物.机理研究表明,以碳为中心的自由基是中间的.
Doi:10.1002/anie.201710089

专利信息

专利号:US-7102023-B2
优先权日:1999-11-24
标 题:Protecting groups useful in the synthesis of polysaccharides, natural products, and combinatorial libraries
发明人：BUCHWALD STEPHEN L; PLANTE OBADIAH J; SEEBERGER PETER H
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:One aspect of the present invention relates to optionally substituted halogenated benzyl halides and the like. These compounds are useful as halogenated benzyl ether-based protecting groups for a variety of functional groups. Another aspect of the present invention relates to use of said protecting groups in an orthogonal protecting group strategy for the synthesis of complex molecules that comprise a number of suitable functional groups. Another aspect of the present invention relates to saccharides bearing various arrays of protecting groups of the present invention. Another aspect of the present invention relates to a method of synthesizing an oligosaccharide or glycoconjugate, comprising the steps of: using a saccharide bearing at least one protecting group of the present invention to glycosylate a second molecule to give a product comprising said saccharide; and removing a protecting group of the present invention from said product.

专利号:US-2025026768-A1
优先权日:2023-06-30
标题:Method for the synthesis of axially chiral organoboron compounds
发明人：PING YIFAN; CHE CHI-MING
权利人:LABORATORY FOR SYNTHETIC CHEMISTRY AND CHEMICAL BIOLOGY LTD
摘要:A highly efficient and atroposelective Rh-catalyzed [2+2+2] cycloaddition for the synthesis of axially chiral aryboron compounds is developed. The reactions of diynes and alkynylborons smoothly occur in an atom-economical manner, affording a variety of C—B atropisomers in excellent yields and enantioselectivities. The protocol features mild conditions, broad substrate scope, and good functional tolerance. The obtained C—B atropisomers show powerful synthetic applications in terms of producing novel chiral phosphine ligands.

专利号:US-7893286-B2
优先权日:2007-06-01
标题 :Method for the synthesis of phospholipid ethers
发明人：PINCHUK ANATOLY; WEICHERT JAMEY P; LONGINO MARC
权利人:CELLECTAR INC
摘要:Disclosed are improved methods for the synthesis of phospholipid ether analogs and alkyl phosphocholine analogs. The methods allow greater versatility of the reactants used and greater ease in synthesizing alkyl chains of varying length while affording reaction temperatures at room temperature or below. The methods disclosed herein provide reactants and conditions using alkyl halides and organozinc reagents and do not utilize Gringard reactions thus, allowing greater ease of their separation and purity of products. The PLE compounds synthesized by the methods disclosed herein can also be used for synthesizing high specific activity phospholipid ether (PLE) analogs, for use in treatment and diagnosis of cancer.

专利号:US-5684130-A
优先权日:1995-06-05
标题 :Process for synthesis of organic compounds using magnetic particles
发明人：SUCHOLEIKI IRVING
权利人:SOLID PHASE SCIENCES CORP
摘要:This invention provides a process for the synthesis of a defined chemical entity, i.e., any desired chemical compound, in high yield using a solid support comprising a magnetic particle, in organic solvents. In general, a sequence of chemical synthetic steps are required to prepare the defined chemical entity bound to the particle. The particle comprises a resin bearing a high concentration of substituent pendant functional groups, to which the first reagent employed in the synthetic sequence binds; in subsequent reaction steps further reagents react with the growing chemical intermediate bound to the pendant functional groups until the defined chemical entity is obtained. The particle also comprises smaller paramagnetic or superpara-magnetic particles incorporated within the resin. The magnetic particle therefore responds to imposed magnetic field gradients, permitting ease of manipulation in steps involving removal of organic solvent.

专利号:US-8754259-B2
优先权日:2008-08-15
标 题 :Synthesis of cyclohexane derivatives useful as sensates in consumer products
发明人：YELM KENNETH EDWARD; BUNKE GREGORY MARK; HAUGHT JOHN CHRISTIAN
权利人:PROCTER & GAMBLE; PROCTER & GAMBLE
摘要:The present invention provides synthetic routes for preparing various isomers of cyclohexane-based coolants, such as menthyl esters and menthanecarboxamide derivatives, in particular those substituted at the amide nitrogen, for example with an aromatic ring or aryl moiety. Such structures have high cooling potency and long lasting sensory effect, which make them useful in a wide variety of consumer products. One synthetic route involves a copper catalyzed coupling of a primary menthanecarboxamide with an aryl halide, such reaction working best in the presence of potassium phosphate and water. Using this synthetic route, specific isomers can be prepared including the menthanecarboxamide isomer having the same configuration as l-menthol and new isomers such as a neoisomer having opposite stereochemistry at the carboxamide (C-1) position. The neoisomer unexpectedly has potent and long lasting cooling effect. Preparation schemes for neoisomers of other menthyl derivatives which are useful as coolants, including esters, ethers, carboxy esters and other N-substituted carboxamides are also provided.

专利号:US-7741492-B2
优先权日:2005-02-28
标题:Method for obtaining a pharmaceutically active compound (Irbesartan) and its synthesis intermediate
发明人：HUGUET CLOTET JOAN; DALMASES BARJOAN PERE
权利人:INKE SA
摘要:It is provided a method for obtaining Irbesartan polymorph A, with few synthesis steps, by coupling the intermediate of formula (II) with the compound of formula (III), neutralising one of its alkaline salts in an aqueous medium and recrystallising the crude product obtained. The utilisation of said method obviates protection and deprotection of the tetrazole ring and is therefore of considerable interest for obtaining Irbesartan on a large industrial scale. The invention also refers to the synthesis intermediate of formula (II).