专利号:US-8569560-B2 优先权日:2006-10-13 标题 :Synthesis of terminal alkenes from internal alkenes via olefin metathesis 发明人:SCHRODI YANN; PEDERSON RICHARD L; KAIDO HIROKI; TUPY MICHAEL J 权利人:ELEVANCE RENEWABLE SCIENCES 摘要:This disclosure relates generally to olefin metathesis, and more particularly relates to the synthesis of terminal alkenes from internal alkenes using a cross-metathesis reaction catalyzed by an olefin metathesis catalyst. According to one aspect, for example, a method is provided for synthesizing a terminal olefin, the method comprising contacting, in the presence of a ruthenium alkylidene metathesis catalyst, an olefinic substrate comprised of at least one internal olefin with a cross metathesis partner comprised of an alpha olefinic reactant, under reaction conditions effective to allow cross-metathesis to occur, wherein the reaction conditions include a reaction temperature of at least 35° C. The methods, compositions, reactions and reaction systems herein disclosed have utility in the fields of catalysis, organic synthesis, and industrial chemistry.
专利号:US-8188141-B2 优先权日:2004-09-23 标题 :Isomigrastatin analogs in the treatment of cancer 发明人:DANISHEFSKY SAMUEL J; MANDAL MIHIRBARAN; DORN DAVID C; MOORE MALCOLM A S 权利人:DANISHEFSKY SAMUEL J; MANDAL MIHIRBARAN; DORN DAVID C; MOORE MALCOLM A S; SLOAN KETTERING INST CANCER 摘要:The present invention provides compounds having formula (I): (I) wherein n, R 1 -R 5 , R a -R b , Q, Y 1 and Y 2 are as defined herein; and additionally provides methods for the synthesis thereof, compositions thereof, and methods for the use thereof in the treatment of various disorders including cancer, metastasis and disorders involving increased angiogenesis.
专利号:US-2013035532-A1 优先权日:2006-10-13 标题 :Synthesis of terminal alkenes from internal alkenes via olefin metathesis
专利号:US-2010145086-A1 优先权日:2006-10-13 标 题:Synthesis of Terminal Alkenes From Internal Alkenes Via Olefin Metathesis
专利号:WO-2008046106-A2 优先权日:2006-10-13 标 题:Synthesis of terminal alkenes from internal alkenes via olefin metathesis
专利号:US-8501973-B2 优先权日:2006-10-13 标题 :Synthesis of terminal alkenes from internal alkenes via olefin metathesis
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