CAS: 119-34-6; 4-Amino-2-Nitrophenol

该化合物是含有分子式C6H6N2O3的有机化合物,其成分在酚状环上有氨基和硝基功能组,该化合物主要用作染料,色素和其他细化学物合成的中间体,因为它具有反应性和形成稳定的亚索化合物的能力.其独特的结构特性使得染料应用中能够精确的色调,使其对工业过程具有价值. 电温(氨基)和电排(硝基)组的存在增强了其在电动力替代反应中的效用.由于它可能具有对光和热的敏感性,需要妥善处理.根据适当的安全议定书,它适合于受控实验室或工业用途.

结构式图片

相似化合物

137-09-7 603-87-2 577-72-0

欧盟法规

ECHA物质ECHA物质化妆品禁用物质清单C&L通报REACH预注册

上下游产品

2,4-Dinitrophenol 3-nitrophenyl azide N-(4-hydroxy-3-nitrophenyl)acetamide 2-nitro-4-azidophenol 4-diazo-2-nitrophenol N-(4-hydroxy-3-nitrophenyl)acetamide N-acetyl-sulfanilic acid-(4-hydroxy-3-nitro-anilide)N-acetyl-sulfanilic acid-(4-hydroxy-3-nitro-anilide) (4-Hydroxy-3-nitrophenyl)trimethylammonium Iodide

合成工艺路线路线简述

    📜2,4-二硝基酚置于sodium Tetrahydroborate体系中,用 水 用作溶剂,化学反应 0.03H,反应生成2-硝基-4-氨基苯酚
    参考文献:Magnetically Recoverable Gold Nanorods As A Novel Catalyst For The Facile Reduction Of Nitroarenes Under Aqueous Conditions
    标题:Magnetically Recoverable Gold Nanorods As A Novel Catalyst For The Facile Reduction Of Nitroarenes Under Aqueous Conditions
    摘要:In This Work,Cysteine-Functionalized Fe3O4@carbon Magnetic Nanoparticles Were Used For The Synthesis Of Gold Nanorods. Fe3O4@c Nanoparticles Were First Prepared By Synthesis Of Fe3O4 Magnetic Nanoparticles (Mnps),And Then Carbon-Coated Mnps (Fe3O4@c) Were Synthesized By Glucose Carbonization Using A Hydrothermal Method. Finally,The Gold Nrs Were Loaded On The Modified Surface Of Fe3O4@c Mnps. The Designed Magnetically Recoverable Gold Nanorods,After Full Characterization By Ftir,Sem,Tem,Tga,Vsm,Xrd,And Icp-Oes,Were Applied To The Reduction Of Nitroarenes. The Fe3O4@c@cys-Au Nanorods Showed Higher Performance Than Fe3O4@c@cys-Au Nanospheres In A Selective Facile Reduction Of Nitroarenes To The Corresponding Aminoarenes In Aqueous Medium At Room Temperature Using Nabh4.[graphics].
    Doi:10.1007/s10562-016-1921-4

    海关参考信息

    专利信息


    专利号:US-7550510-B2
    优先权日:2001-07-06
    标 题 :Solid phase synthesis of arylretinamides
    发明人:CURLEY JR ROBERT W; MERSHON SERENA M; BARNETT DEREK W; CLAGETT-DAME MARGARET; CHAPMAN JASON S
    权利人:WISCONSIN ALUMNI RES FOUND
    摘要:A solid phase synthetic method for preparing arylretinamides is provided. The method comprises reacting hexachloroacetone with a solvent-suspended resin-bound triphenylphosphine to provide a suspension comprising an activated chlorinating reagent; reacting retinoic acid with the activated chlorinating reagent to provide retinoyl chloride; adding pyridine and a select arylamine to the resulting mixture; and stirring the resulting mixture for a time and at a temperature sufficient for the select arylamine to react with the retinoyl chloride and provide the arylretinamide. Also provided, are select arylretinamides that can be prepared by the present method, and methods of using such arylretinamides to induce apoptosis in cancer cells.

    专利号:US-2004102650-A1
    优先权日:2001-07-06
    标 题:Solid phase synthesis of arylretinamides

    专利号:US-2003105164-A1
    优先权日:2001-07-06
    标 题 :Solid phase synthesis of arylretinamides

    专利号:WO-03003987-A2
    优先权日:2001-07-06
    标题:Solid phase synthesis of arylretinamides

    专利号:US-6696606-B2
    优先权日:2001-07-06
    标 题 :Solid phase synthesis of arylretinamides

    专利号:US-2009137566-A1
    优先权日:2005-05-26
    标 题 :Substituted Piperdines as Renin Inhibitors
    发明人:EHARA TAKERU; HITOMI YUKO; KONISHI KAZUHIDE; MASUYA KELICHI
    权利人:EHARA TAKERU; HITOMI YUKO; KONISHI KAZUHIDE; MASUYA KELICHI
    摘要:The invention relates to substituted 3,4- or higher substituted piperididine compounds, the use thereof for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; pharmaceutical formulations or products comprising said compounds, and/or a method of treatment comprising administering said compounds, a method for the manufacture of said compounds, as well as novel intermediates, starting materials and/or partial steps for their synthesis. The compounds preferably have the formula I, n n n n n n n n n n wherein the moieties R1, R2, R11 and W are as defined in the specification.

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    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: R L Bronaugh, Et Al. Percutaneous Absorption Of Nitroaromatic Compounds: In Vivo And In Vitro Studies In The Human And Monkey. J Invest Dermatol. 1985 Mar;84(3):180-3.
    [参考文献]: T A Robert, Et Al. Plasma Levels And Kinetic Disposition Of 2,4-Dinitrophenol And Its Metabolites 2-Amino-4-Nitrophenol And 4-Amino-2-Nitrophenol In The Mouse. J Chromatogr. 1985 Nov 8:344:177-86.

    合成参考文献


    摘要:Journal of Toxicology and Environmental Health., 2(657), 1977 []
    摘要:
    摘要:Sittig, M. Handbook of Toxic and Hazardous Chemicals and Carcinogens, 2002. 4th ed.Vol 1 A-H Norwich, NY: Noyes Publications, 2002., p. 137
    摘要:Lyman WJ et al; Handbook of Chemical Property Estimation Methods. Washington, DC: Amer Chem Soc pp. 7-4, 7-5, 8-12 (1990)
    摘要:Atkinson R; J Phys Chem Ref Data Monogr 2: 1-216 (1994)
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