CAS: 105379-24-6; (1H-Benzo[d][1,2,3]Triazol-1-yl)(Di(Pyrrolidin-1-yl)Methylene)Oxonium Hexafluorophosphate(V)

该化合物是一种化学化合物,在有机合成中,特别是在药用化学领域,是一种多用途试剂,其特点是其独特的二硝基氨基氨基氨结构,它增强了其反应的回动性和稳定性;苯三氮基苯的出现有助于其作为强大电极的能力,使其在组合反应和其他变异方面有所助益;六氟磷酸烷离子在极地溶剂中提供极好的溶解性,便利其在不同反应条件下的使用;此外,该化合物的热稳定性是众所周知的,可在标准实验室条件下处理,其应用范围扩大到复杂的有机分子合成,包括制药和农用化学,在推动联结形成和功能性组变过程中发挥着至关重要的作用.与许多化学物质一样,在处理该化合物时,由于其反应性质,应当采取适当的安全措施.

英文名称(1H-Benzo[d][1,2,3]Triazol-1-yl)(Di(Pyrrolidin-1-yl)Methylene)Oxonium Hexafluorophosphate(V)
中文名称(苯并三唑-1-基)-N,N,N',N'-二吡咯基脲六氟磷酸酯
IUPAC名称(1H-benzo[d][1,2,3]triazol-1-yl)(di(pyrrolidin-1-yl)methylene)oxonium hexafluorophosphate(V)
其它别名O-(苯并三唑-1-基)-N,N,N',N'-双(四亚甲基)六氟磷酸脲; (Benzotriazol-1-Yloxy)Dipyrrolidinocarbenium Hexafluorophosphate
CAS编号105379-24-6
MFCD编号:MFCD00191770
EINECS号:628-483-9
分子式:C15H20F6N5OP
分子量:431.32
产品CID: 95034
产品分类有机原料→分子砌块→芳杂环类化合物→其它芳杂环类化合物

相似结构搜索
InChIKey: XKTRAGMCMJYRRN-UHFFFAOYSA-N
XKTRAGMCMJYRRN-UHFFFAOYSA-N…
计算化学: 氢键受体数4.0氢键供体数0.0可旋转键数1.0

相似化合物

206752-41-2 94790-37-1 125700-67-6

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2
警示词Warning(警告)
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
UN编号NONH for all modes of transport
危险品标志Xi
安全声明26-36
危险类别码36/37/38
WGK Germany3

欧盟法规

C&L通报

合成工艺路线路线简述

专利信息

专利号:US-2019177392-A1
优先权日:2014-09-23
标题 :Synthesis of glp-1 peptides
发明人：PENIAS NAVON SHARON; NAVEH SHIRLY; VASILEIOU ZOI; BARLOS KONSTANTINOS
权利人:NOVETIDE LTD
摘要:Disclosed are processes for the synthesis of GLP-1 peptides, such as liraglutide and semaglutide, and a process for purifying liraglutide.

专利号:US-2025101006-A1
优先权日:2022-01-31
标题:Process for the synthesis of pyrazolyl derivatives useful as anti-cancer agents
发明人：BAENZIGER MARKUS; GALLOU FABRICE; GUO FENGFENG; HÃ„NGGI RUDOLF; HAN ENJIAN; JORDINE GUIDO; LI JIALIANG; LIU WEIPENG; MIAO BUKEYAN; RONG SHAOFENG; SANTANDREA ERNESTO; SCHIRNER PAUL BERND; SHEN XIAODONG; WANG CAN; ZHANG HAO
权利人:NOVARTIS AG
摘要:The invention provides a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially KRAS G12C inhibitors. The present invention provides a direct enantioselective chemical manufacturing method of making Compound A, or a pharmaceutically acceptable hydrate or solvent thereof: (I). The invention provides a process for preparing Intermediate B6* comprising reacting Intermediate B4* with Intermediate B5* in an atroposelective coupling reaction, using a chiral catalyst.

专利号:US-2022233673-A1
优先权日:2019-06-04
标题:METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STxB) MONOMERS AND OLIGOMERS, AND USES THEREOF
发明人：BILLET ANNE; SCHMIDT FRÃ‰DÃ‰RIC; JOHANNES LUDGER; SERVENT DENIS; MOURIER GILLES; TARTOUR Ã‰RIC; KAY MICHAEL; FULCHER JAMES M
权利人:INST CURIE; CENTRE NAT RECH SCIENT; INST NAT SANTE RECH MED; COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES CEA; APHP ASSIST PUBLIQUE HOPITAUX DE PARIS; UNIV PARIS; UNIV OF UTAH RESEARCH FOUDATION; UNIV UTAH RES FOUND
摘要:A method of producing a monomer of a Shiga toxin B-subunit (STxB) protein or of a variant thereof by peptide chemical synthesis, as well as to a method of producing a pentamer of the STxB protein or of the variant thereof. The methods are particularly advantageous as they overcome major issues typically observed in peptide chemical synthesis, including solubility and purity issues.

专利号:WO-2023143605-A1
优先权日:2022-01-31
标题:Process for the synthesis of pyrazolyl derivatives useful as anti-cancer agents

专利号:CN-115109118-A
优先权日:2021-03-19
标题:A kind of method for solid-phase synthesis of DS-8201 intermediate and preparation method of DS-8201

专利号:EP-4472969-A1
优先权日:2022-01-31
标题 :Process for the synthesis of pyrazolyl derivatives useful as anti-cancer agents