CAS: 99769-19-4; 3-(Methoxycarbonyl)Phenylboronic Acid

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CAS号618-91-7 3-碘苯甲酸甲酯 | CAS号618-89-3 3-溴苯甲酸甲酯 | CAS号2905-65-9 间氯苯甲酸甲酯 | CAS号1097777-59-7 methyl 3-(4-hyd... | CAS号1097777-60-0 艾曲波帕杂质14 | CAS号455-68-5 3-氟苯甲酸甲酯 | CAS号618-91-7 3-碘苯甲酸甲酯 | CAS号480425-35-2 3-甲氧羰基苯硼酸频哪醇酯 | CAS号281234-49-9 4'-甲酰基-[1,1'-联苯... | CAS号2557-13-3 间三氟甲基苯甲酸甲酯 | CAS号63555-50-0 3-甲氧基羰基苯磺酰氯 | CAS号618-95-1 3-硝基苯甲酸甲酯 | CAS号4518-10-9 3-氨基苯甲酸甲酯

间氯苯甲酸甲酯置于四羟基二硼,氯(2-二环己基膦基-2',4',6'-三异丙基-1,1'-联苯基)[2-(2'-氨基-1,1'-联苯)]钯(II),Potassium Acetate,2-二环己基磷-2,4,6-三异丙基联苯体系中,用 乙醇 作为反应溶剂,化学反应 2.5H,反应生成 3-甲氧基羰基苯硼酸
参考文献:使用双硼酸的钯催化芳基硼化反应的范围
标题:使用双硼酸的钯催化芳基硼化反应的范围
摘要:Suzuki-Miyaura 反应已成为合成有机化学家更有用的工具之一.直到最近,还没有直接的方法来制造偶联反应中最重要的成分,即硼酸.目前制造硼酸的方法通常使用苛刻或浪费的试剂来制备硼酸衍生物,并且需要额外的步骤来提供所需的硼酸.先前报道的钯催化的直接硼酸合成的范围被揭开,其中包括广泛的合成有用的芳基亲电试剂.它利用新推出的第二代 Buchwald Xphos 预制钯催化剂和双硼酸.为了便于隔离并保留通常敏感的 Cb 键,
DOI:10.1021/ja303181M

专利信息

专利号:US-2010029904-A1
优先权日:2005-09-20
标题 :Carrier for Separation, Method for Separation of Compound, and Method for Synthesis of Peptide Using the Carrier

专利号:US-8633298-B2
优先权日:2005-09-20
标 题 :Carrier for separation, method for separation of compound, and method for synthesis of peptide using the carrier

专利号:US-2014107319-A1
优先权日:2005-09-20
标 题 :Carrier for separation, method for separation of compound, and method for synthesis of peptide using the carrier

专利号:US-7671085-B2
优先权日:2002-11-15
标 题 :Non-steroidal farnesoid X receptor modulators and methods for the use thereof
发明人：DOWNES MICHAEL R; EVANS RONALD M
权利人:SALK INST FOR BIOLOGICAL STUDI
摘要:The efficient regulation of cholesterol synthesis, metabolism, acquisition, and transport is an essential component of lipid homeostasis. The farnesoid X receptor (FXR) is a transcriptional sensor for bile acids, the primary product of cholesterol metabolism. Accordingly, the development of potent, selective, small molecule agonists, partial agonists, and antagonists of FXR would be an important step in further deconvoluting FXR physiology. In accordance with the present invention, the identification of novel potent FXR activators is described. Two derivatives of invention compounds, bearing stilbene or biaryl moieties, contain members that are the most potent FXR agonists reported to date in cell-based assays. These compounds are useful as chemical tools to further define the physiological role of FXR as well as therapeutic leads for the treatment of diseases linked to cholesterol, bile acids and their metabolism and homeostasis.

专利号:US-8178559-B2
优先权日:2004-12-30
标 题:Organic compounds
发明人：BREITENSTEIN WERNER; EHARA TAKERU; EHRHARDT CLAUS; GROSCHE PHILIPP; HITOMI YUKO; IWAKI YUKI; KANAZAWA TAKANORI; KONISHI KAZUHIDE; MAIBAUM JUERGEN KLAUS; MASUYA KEIICHI; IWASAKI ATSUKO; OSTERMANN NILS; SUZUKI MASAKI; TOYAO ATSUSHI; YOKOKAWA FUMIAKI
权利人:BREITENSTEIN WERNER; EHARA TAKERU; EHRHARDT CLAUS; GROSCHE PHILIPP; HITOMI YUKO; IWAKI YUKI; KANAZAWA TAKANORI; KONISHI KAZUHIDE; MAIBAUM JUERGEN KLAUS; MASUYA KEIICHI; IWASAKI ATSUKO; OSTERMANN NILS; SUZUKI MASAKI; TOYAO ATSUSHI; YOKOKAWA FUMIAKI; NOVARTIS AG
摘要:3,4-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,4-substituted piperidine compound, and/or a method of treatment comprising administering a 3,4substituted piperidine compound, a method for the manufacture of a 3,4-substituted piperidine compound, and novel intermediates and partial steps for their synthesis are disclosed. The 3,4-disubstituted piperidine compounds have the formula (I), wherein the symbols have the meanings defined in the specification.