CAS: 99-12-7; 1,3-Dimethyl-5-Nitrobenzene

该化合物是一种芳香化合物,其特点是以两个甲基组和一个硝基组取代苯环,甲基组位于1和3个位置,而硝基组位于5个位置,从而具有影响其化学特性的具体结构安排.该化合物一般是黄色至褐色固体,以其在水中的溶解性相对较低而闻名,但在乙醇和丙酮等有机溶剂中可溶解.该化合物表现出典型的芳香特性,包括电子生物替代反应的稳定性和再活性.该硝基组的存在引入了电吸附特性,可能影响芳基环的再活动性. 1,3-二甲基-5-硝基苯在各种应用中使用,包括作为有机合成的中间体以及染料和药品的生产中.在处理该化合物时,应当采取安全防范措施,因为如果吸入或吸食,可能会对健康造成危害.

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上下游产品

CAS号556-96-7 5-溴间二甲苯 | CAS号172975-69-8 3,5-二甲基苯硼酸 | CAS号108-69-0 3,5-二甲基苯胺 | CAS号108-38-3 间二甲苯 | CAS号1635-84-3 4,6-二甲基-2-硝基苯胺 | CAS号22445-41-6 3,5-二甲基-1-碘苯 | CAS号2050-43-3 N-(2,4-二甲基苯基)乙酰胺 | CAS号10442-39-4 氰化四丁基胺 | CAS号606-38-2 4-乙酰氨基-5-硝基间二甲苯 | CAS号4913-13-7 N,N,3,5-四甲基苯胺 | CAS号59557-90-3 4-溴-3,5-二甲基苯胺 | CAS号20150-89-4 5,7-dimethylqui... | CAS号22409-76-3 5-bromo-2-(4-br... | CAS号618-88-2 5-硝基间苯二甲酸 | CAS号113882-33-0 3-甲基-5-硝基苯甲酸 | CAS号585-81-9 3-羟基-5-甲基苯甲酸 | CAS号102871-67-0 2,5,7-三甲基喹啉 | CAS号108-69-0 3,5-二甲基苯胺 | CAS号21161-11-5 2-硝基间苯二甲酸

合成工艺路线路线简述

    📜4-乙酰氨基-5-硝基间二甲苯置于盐酸体系中,化学反应生成 5-硝基间二甲苯
    参考文献:Van Loon,A. Et Al.,Recueil Des Travaux Chimiques Des Pays-Bas,1960,Vol. 79,P. 977-1001
    标题:Van Loon,A. Et Al.,Recueil Des Travaux Chimiques Des Pays-Bas,1960,Vol. 79,P. 977-1001

    海关参考信息

    专利信息


    专利号:US-4476315-A
    优先权日:1982-04-30
    标 题:Nucleophilic substitution process
    发明人:STAHLY G PATRICK; STAHLY BARBARA C
    权利人:ETHYL CORP
    摘要:Nitroarylacetic acid esters are prepared by reacting a nitroaromatic compound which is devoid of halogen on the aromatic ring carrying a nitro group with an alpha,alpha-disubstituted acetic acid ester in an inert solvent and in the presence of a base so that the ester undergoes a nucleophilic substitution on an unsubstituted ring carbon of the nitroaromatic compound during which an alpha-substituent functions as a leaving group. Nitrobenzene acetic acids and their esters are useful intermediates for the synthesis of pharmaceuticals.

    专利号:US-4499026-A
    优先权日:1982-08-25
    标题 :Nucleophilic substitution process
    发明人:STAHLY BARBARA C; STAHLY G PATRICK
    权利人:ETHYL CORP
    摘要:Nitroarylacetonitriles are prepared by reacting a nitroaromatic compound which is devoid of halogen on the aromatic ring carrying a nitro group with an alpha,alpha-disubstituted acetonitrile in an inert solvent and in the presence of a base so that the nitrile undergoes a nucleophilic substitution on an unsubstituted ring carbon of the nitroaromatic compound during which an alpha-substituent functions as a leaving group. Nitrobenzene acetic acids and their nitriles are useful intermediates for the synthesis of pharmaceuticals.

    专利号:CN-103265450-B
    优先权日:2013-06-04
    标 题 :Method for photocatalytic synthesis of azoxybenzene and azobenzene compounds

    专利号:CN-1651413-A
    优先权日:2004-11-25
    标 题:Synthesis method of single optical isomer nitrendipine

    专利号:RU-2117659-C1
    优先权日:1992-02-04
    标题:Carbopenem derivatives, their pharmaceutically acceptable salts and hydrolyzed in vivo esters (variants), method of synthesis (variants), pharmaceutical composition showing antibacterial activity, derivatives of pyrrolidine-4-ylthiol and protected derivatives of pyrrolidine-4-ylthiol

    专利号:CN-111995524-A
    优先权日:2020-08-28
    标题 :The continuous synthesis method of 5-nitroisophthalic acid

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    合成参考文献

    合成方法参考DOI号:10.2174/157017812800221717
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