CAS: 85272-31-7; Di-Tert-Butylsilanediyl Bis(Trifluoromethanesulfonate)

该化合物是一种化学化合物,其独特的结构特征包括一个粘结到一个全氟辛烷磺酸组和两个成体成体的硅原子,以及两个成体成体-丁基组.该化合物因其三氟甲基组群的强性,增强反应性和稳定性,使其在各种化学应用中有用,特别是在有机合成和氟化反应中的试剂方面.该化合物的存在有助于其在极溶溶剂中的溶性,而成体-丁基组群则具有阻塞性,影响其化学反应中的再活性和选择性.此外,该化合物的三氟化乙烷基磺酸混合物具有很强的遗传性,因此在氟化化合物合成中成为有价值的中间体.

结构式图片

相似化合物

80522-42-5 69739-34-0 85272-30-6

欧盟法规

REACH注册ECHA物质C&L通报

上下游产品

CAS号1493-13-6 三氟甲烷磺酸 | CAS号56310-18-0 二叔丁基氯硅烷 | CAS号18395-90-9 二叔丁基氯硅烷

合成工艺路线路线简述

  • 合成目标产物 Di-Tert-Butylsilyl Bis(Trifluoromethanesulfonate) 主要起始原料 Trifluoromethanesulfonic Acid And Di-Tert-Butylchlorosilane
  • 1493-13-6 + 56310-18-0 = 85272-31-7 [标题:Reaction Conditions
    标题:Diisopropylsilyl Ditriflate And Di-Tert-Butylsilyl Ditriflate: New Reagents For The Protection Of Diols
    作者:Corey,E. J.; Hopkins,Paul B.
    参考文献:Tetrahedron Letters 日期:1982 卷标:23(47) 页码:4871-4]

    1493-13-6 + 56310-18-0 = 85272-31-7 [标题:Reaction Conditions
    标题:Di-Tert-Butylchlorosilane
    作者:Hargaden,Grainne C.; O'Sullivan,Timothy P.
    参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2011 卷标:1 页码:1-3]

    1493-13-6 + 56310-18-0 = 85272-31-7 [标题:Reaction Conditions
    标题:Di-T-Butylsilyl Bis(Trifluoromethanesulfonate)
    作者:Sigurdsson,Snorri T.; Hopkins,Paul B.; Belani,Jitendra; Ghosh,Samir; Andreana,Peter R.
    参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2015 卷标:1 页码:1-27]

    421-83-0 + 96284-27-4 = 85272-31-7 + 117559-35-0 + 78393-18-7 + 74010-26-7
    反应条件:1.1 Solvents: Tert-Butyl Methyl Ether; -78 °C; -78 °C -> Rt
    标题:Synthesis And Crystal Structures Of Tbu-Substituted Disiloxanes Tbu2Six-O-Siytbu2 (X = Y = Oh,Br; X = Oh,Y = H) And Of The Adducts Tbu3Sioh.(Ho3Scf3)0.5.H2O And Tbu3Sioli.(Lio3Scf3)2.(H2O)2
    作者:Lerner,H.-W.; Scholz,S.; Wiberg,N.; Polborn,K.; Bolte,M.; Et Al
    参考文献:Zeitschrift Fuer Anorganische Und Allgemeine Chemie 日期:2005 卷标:631(10) 页码:1863-1870
二叔丁基氯硅烷置于silver Trifluoromethanesulfonate体系中,化学反应生成 二叔丁基硅基双(三氟甲烷磺酸)
参考文献:Furusawa,Kiyotaka; Ueno,Katsuhiko; Katsura,Tatsuo,Chemistry Letters,1990,P. 97-100
标题:Furusawa,Kiyotaka; Ueno,Katsuhiko; Katsura,Tatsuo,Chemistry Letters,1990,P. 97-100

专利信息


专利号:US-12378246-B2
优先权日:2019-04-11
标 题:Synthetic options towards the manufacture of (6R,10S)-10-{4-[5-chloro-2-(4-chloro-1H-1,2,3-triazol-1-yl)phenyl]-6-oxo-1(6H)-pyrimidinyl} - 1-(difluoromethyl)-6-methyl-1,4,7,8,9,10-hexahydro-11,15-(metheno)pyrazolo[4,3-b][1,7]diazacyclotetradecin-5(6H)-one
发明人:CUNIERE NICOLAS; FAN YU; KOLOTUCHIN SERGEI; MUKHERJEE SUBHA; SIMMONS ERIC M; SINGH AMARJIT; WEI CAROLYN S; XIAO YI; YUAN CHANGXIA; ZHENG BIN; WAGSCHAL SIMON ALBERT; BROGGINI DIEGO FERNANDO DOMENICO; CAO DUY CHI TRUNG; CHERNICHENKO KOSTIANTYN; LEMAIRE SEBASTIEN FRANCOIS EMMANUEL; BEN HAÃ?M CYRIL
权利人:BRISTOL MYERS SQUIBB CO; JANSSEN PHARMACEUTICA NV
摘要:Highly efficient methods are provided for preparing key intermediates in the synthesis of Compound (I), which are broadly applicable and can provide selected components having a variety of substituents groups.

专利号:US-2003236377-A1
优先权日:2002-02-19
标题:Synthesis of A,B-alternating copolymers by olefin metathesis reactions of cyclic olefins or olefinic polymers with an acyclic diene

专利号:US-2005059817-A1
优先权日:2000-09-01
标题 :Methods for synthesizing nucleosides, nucleoside derivatives and non-nucleoside derivatives
发明人:BEIGELMAN LEONID; KARPEISKY ALEXANDER; SEREBRYANY VLADMIR; HAEBERLI PETER; SWEEDLER DAVID
权利人:SIRNA THERAPEUTICS INC
摘要:The present invention provides methods for the chemical synthesis of nucleosides and derivatives thereof, including 2′-amino, 2′-N-phthaloyl, 2′-O-methyl, 2′-0-silyl, 2′-O-triisopropylsilyloxymethyl, 2′-OH nucleosides, C-nucleosides, nucleoside phosphoramidites, C-nucleoside phosphoramidites, and non-nucleoside derivatives.

专利号:US-9512426-B2
优先权日:2009-12-17
标 题:Method for rapidly evaluating performance of short interfering RNA with novel chemical modifications
发明人:BUTORA GABOR; DAVIES IAN W; FLANAGAN WILLIAM MICHAEL; FU WENLANG; KENSKI DENISE M; QI NING
权利人:SIRNA THERAPEUTICS INC
摘要:It is an object of the instant invention to provide a method for the rapid evaluation of novel sugar modifications to be used in siRNA synthesis including the rapid evaluation of chemical modification patterns within the siRNA to effectuate increased stability and ultimately increased efficacy of a siRNA therapeutic. It is a further object of the instant invention to provide novel nucleosides useful for siRNA therapy.

专利号:US-9290521-B2
优先权日:2012-04-27
标 题 :Method for protecting hydroxyl or amine or thiol functions, novel compounds with protected hydroxyl or amine or thiol groups, as well novel compounds for the implementation of this method
发明人:MARKIEWICZ WOJCIECH TADEUSZ; CHMIELEWSKI MARCIN KRZYSZTOF; MUSIAL SYLWIA MARIA; MACIEJEWSKI HIERONIM FRANCISZEK; HRECZYCHO GRZEGORZ
权利人:INST CHEMII BIOORG POLSKIEJ AKADEMII NAUK; FUNDACJA UNIV U IM ADAMA MICKIEWICZA W POZNANIU
摘要:A novel method of simultaneously protecting two functions which are same or different, namely hydroxyl, amine, or thiol ones, particularly in sugars, polyalcohols, nucleosides, nucleotides, peptides, and nucleic acids during an organic synthesis, and to novel compounds for implementing this method, as well as to the method of obtaining these compounds. Method of simultaneously protecting two hydroxyl, amine, or thiol functions according to the invention by carrying out a protecting reaction between a compound having at least two free hydroxyl, amine, or thiol groups, and the disilane of formula 1, n nwhere R stands for Cl or Br, or I, or a substituent of formula 2,n n nwhere X 1 , X 2 , X 3 , X 4 are the same or different.

专利号:US-6987154-B2
优先权日:2002-02-19
标 题:Synthesis of A,B-alternating copolymers by olefin metathesis reactions of cyclic olefins or olefinic polymers with an acyclic diene
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主要参考文献

参考标题:Total Synthesis Of The Macrolide Antibiotic Cytovaricin
作者:David A. Evans,Stephen W. Kaldor,Todd K. Jones,Jon Clardy,Thomas J. Stout |发布日期:1990.9
摘要:A Convergent Asymmetric Synthesis Of The Antinoeplastic Macrolide Antibiotic Cytovaricin Has Been Achieved Through The Synthesis And Coupling Of The Illustrated Spiroketal And Polyol Glycoside Subunits. All Absolute Steroechemical Relationships Within The Target Structure Were Ultimately Controlled By The Use Of Asymmetric Aldol, Alkylation, Or Epoxidation Methodology. Union Of The Two Subnits Was

合成参考文献


参考文献:10.1007/s10719-008-9117-9
摘要:Komori T, Ando T, Imamura A, Li YT, Ishida H, Kiso M. Design and efficient synthesis of novel GM2 analogues with respect to the elucidation of the function of GM2 activator. Glycoconj J. 2008 Oct;25(7):647–61. doi: 10.1007/s10719-008-9117-9.
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