CAS: 828-01-3; 2-Hydroxy-3-Phenylpropanoic Acid
该化合物是一种有机化合物,属于甲型氢氧酸类别,其特征是同一碳链上既存在碳盒酸,也存在氢氧基,特别是相对于碳箱酸组的第三个碳位置.该化合物是一种种族混合物,含有对映剂,这意味着它有两种镜像形式,可以显示不同的生物活动.3-苯丙酸一般是白色到白外晶状固体,在水中可溶解,在各种应用中有用,包括制药和化妆品.它有其潜在的抗微生物特性,在代谢过程中的作用也受到研究.此外,它可以参与其他化学化合物的合成,并可以作为有机合成的血管建筑块.其稳定性和再活性可视环境条件(例如pH)和温度而有所不同.
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;;;; - InChIKey: VOXXWSYKYCBWHO-UHFFFAOYNA-N
- 1S/C9H10O3/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8,10H,6H2,(H,11,12)…
- 计算化学: 氢键受体数2.0氢键供体数2.0可旋转键数3.0
物理性质
上下游产品
ethyl 3-phenylglycidate 2-bromo-3-phenylpropanoic acid α-hydrazinobenzenepropanoic acid 2-oxo-3-(phenyl)propionic acidethyl (R)-2-hydroxy-3-phenylpropanoate formic acid phenylacetaldehyde L-3-phenyllactic acid合成工艺路线路线简述
- 1011729-32-0 = 828-01-3
反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Methanol; 22 °C
标题:1-(2,2-Dimethoxyethyl)-2-Isocyanobenzene
作者:Linder,David; Et Al
参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2007]
156-06-9 = 828-01-3
反应条件:1.1 Reagents: Hydrogen Catalysts: Nickel Solvents: Methanol; 1 H,3 Mpa,70 °C
标题:Synthesis Of β-Phenyllactic Acid By Catalytic Hydrogenation Of Phenylpyruvic Acid
作者:Li,Guang-Xing; Et Al
参考文献:Hecheng Huaxue 日期:2002 卷标:10(6) 页码:513-514]
156-06-9 = 828-01-3
反应条件:1.1 Reagents: Formic Acid,Iridium(2+),[n-[(1S,2S)-2-(Amino-Kn)-1,2-Diphenylethyl]-1,1,1-Trifluoromethanes... Solvents: Water
标题:New Efficient Methods For The Preparation Of Natural Product Derivatives
作者:Reber,Stefan
参考文献:2007]
52178-60-6 = 828-01-3 [标题:Reaction Conditions
标题:Compounds From Danshen. 6. A Modified Synthesis Of (+/-)-β-Aryllactic Acids
作者:Wong,Henry N. C.; Et Al
参考文献:Synthesis 日期:1992 卷标:(8) 页码:793-7]
93434-59-4 = 828-01-3
反应条件:1.1 Reagents: Hydrogen Catalysts: Dabco,Palladium Solvents: Tetrahydrofuran; 4 H,50 Psi,Rt
标题:Improved Preparation Of A Key Hydroxylamine Intermediate For Relebactam: Rate Enhancement Of Benzyl Ether Hydrogenolysis With Dabco
作者:Yin,Jianguo; Et Al
参考文献:Organic Process Research & Development 日期:2018 卷标:22(3) 页码:273-277]
150-30-1 = 828-01-3
反应条件:1.1 Reagents: Sodium Nitrite,Sulfuric Acid Solvents: Water; 0 °C; 2 H,0 °C; Overnight,Rt
标题:Controllable Intramolecular Unactivated C(Sp3)-H Amination And Oxygenation Of Carbamates
作者:Guo,Qihang; Et Al
参考文献:Organic Letters 日期:2019 卷标:21(4) 页码:880-884]
63-91-2 = 828-01-3
反应条件:1.1 Catalysts: Nadh,Aminotransferase
标题:Screening And Constructing A Library Of Promoter-5'-Utr Complexes With Gradient Strength In Pediococcus Acidilactici
作者:Jia,Yize; Et Al
参考文献:Acs Synthetic Biology 日期:2023 卷标:12(6) 页码:1794-1803]
63-91-2 = 828-01-3
反应条件:1.1 Solvents: Water; 48 H,Ph 6.4,37 °C
标题:Optimization Of Lactobacillus Plantarum Fermentation Conditions In Producing Phenyllactic Acid
作者:Yang,Xiao-Yuan; Et Al
参考文献:Shipin Keji 日期:2018 卷标:43(9) 页码:19-23]
20334-70-7 = 828-01-3
反应条件:1.1 Reagents: Calcium Carbonate,Water Solvents: Water
标题:The Acidic,Basic,And α-Chymotrypsin-Catalyzed Hydrolyses Of Some Esters. A Kinetic Comparison
作者:Bender,Myron L.; Et Al
参考文献:Journal Of The American Chemical Society 日期:1955 卷标:77 页码:4271-5]
= 828-01-3
反应条件:1.1 Reagents: Selenium Dioxide Solvents: 1,4-Dioxane,Water; Reflux
标题:Modular Access To Quaternary α-Hydroxyl Acetates By Catalytic Cross-Coupling Of Alcohols
作者:Zeng,Guangkuo; Et Al
参考文献:Acs Catalysis 日期:2023 卷标:13(3) 页码:2061-2068]
= 828-01-3
反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Methanol; 22 °C
标题:1-(2,2-Dimethoxyethyl)-2-Isocyanobenzene
作者:Linder,David; Et Al
参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2007]
1011729-32-0 = 828-01-3
反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Methanol; 1 D,Rt
标题:A Stable,Convertible Isonitrile As A Formic Acid Carbanion [-Cooh] Equivalent And Its Application In Multicomponent Reactions
作者:Kreye,Oliver; Et Al
参考文献:Synlett 日期:2007 卷标:(20) 页码:3188-3192]
107-21-1 + 100-51-6 = 828-01-3
反应条件:1.1 Reagents: Potassium Hydroxide Catalysts: (Oc-6-42)-Bromodicarbonyl[n,N′-(6-Phenyl-1,3,5-Triazine-2,4-Diyl-Kn3)Bis[p,P-Bis... Solvents: Tert-Butanol; 8 H,Ph 1,140 °C
标题:Sustainable Synthesis Of α-Hydroxycarboxylic Acids By Manganese Catalyzed Acceptorless Dehydrogenative Coupling Of Ethylene Glycol And Primary Alcohols
作者:Waiba,Satyadeep; Et Al
参考文献:Angewandte Chemie 日期:2023 卷标:62(10)]
156-06-9 = 828-01-3
反应条件:1.1 Catalysts: Iridium(1+),Chloro[2-(4,5-Dihydro-1H-Imidazol-2-Yl-Kn3)Pyridine-Kn][(1,2,3,4,5-... Solvents: Water; 5 Min,80 °C1.2 Reagents: Formic Acid; 1 Min,80 °C; 4 H,80 °C
标题:Iridium-Catalyzed Efficient Reduction Of Ketones In Water With Formic Acid As A Hydride Donor At Low Catalyst Loading
作者:Liu,Ji-Tian; Et Al
参考文献:Green Chemistry 日期:2018 卷标:20(9) 页码:2118-2124]
15399-05-0 = 828-01-3
反应条件:1.1 Reagents: Potassium Hydroxide Solvents: Methanol; Rt; 12 H,Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Rt
标题:Manganese-Promoted Regioselective Ring-Opening Of 2,3-Epoxy Acid Derivatives: A New Route To α-Hydroxy Acid Derivatives
作者:Concellon,Jose M.; Et Al
参考文献:Advanced Synthesis & Catalysis 日期:2009 卷标:351(13) 页码:2178-2184]
= 828-01-3
反应条件:1.1 Reagents: Sulfuric Acid
标题:Unstable 1,1,2-Enetriols As (Probable) Intermediates In The Decarboxylation Of α,β-Diketo Acids
作者:Dahn,Hans; Et Al
参考文献:Journal Of Organic Chemistry 日期:1991 卷标:56(9) 页码:3080-2]
= 828-01-3
反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Methanol; 10 Min,Reflux1.2 Ph 2
标题:Pd-Catalyzed α-Selective C(Sp3)-H Acetoxylation Of Amides Through An Unusual Cyclopalladation Mechanism
作者:Wang,Meining; Et Al
参考文献:Chemical Communications (Cambridge 日期:2015 卷标:51(15) 页码:3219-3222]
13674-16-3 = 828-01-3
反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Methanol,Water; 4 H,Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Rt; Ph 1 - 2
标题:Versatile Biocatalytic C(Sp3)-H Oxyfunctionalization For The Site- Selective And Stereodivergent Synthesis Of α- And β-Hydroxy Acids
作者:Mao,Yingle; Et Al
参考文献:Angewandte Chemie 日期:2023 卷标:62(33)]
13674-16-3 = 828-01-3
反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water; 30 Min,Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 3 - 4
标题:Synthesis Of Danshensu Derivatives
作者:Sun,Ju; Et Al
参考文献:Hecheng Huaxue 日期:2010 卷标:18(2) 页码:215-218]
50353-47-4 = 828-01-3
反应条件:1.1 Reagents: Hydrochloric Acid,Water Solvents: Water
标题:Enzymes In Organic Synthesis. 45. An Evaluation Of The Substrate Specificity And Asymmetric Synthesis Potential Of The Cloned L-Lactate Dehydrogenase From Bacillus Stearothermophilus
作者:Bur,Daniel; Et Al
参考文献:Canadian Journal Of Chemistry 日期:1989 卷标:67(6) 页码:1065-70]
50353-47-4 = 828-01-3
反应条件:1.1 Reagents: Hydrochloric Acid Solvents: 1,4-Dioxane; 6 H,Reflux1.2 Reagents: Sodium Bicarbonate Solvents: Water; Ph 2
标题:Kinetic Resolution Of Mandelate Esters Via Stereoselective Acylation Catalyzed By Lipase Ps-30
作者:Chen,Peiran; Et Al
参考文献:Tetrahedron Letters 日期:2014 卷标:55(14) 页码:2290-2294]
60-12-8 + 1313435-40-3 = 828-01-3
反应条件:1.1 Reagents: Iodobenzene Diacetate Catalysts: Tempo Solvents: Dichloromethane; 4 H,Rt1.2 60 H,Rt1.3 Reagents: Sodium Hydroxide Solvents: Methanol,Water; 24 H,Rt
标题:Metal-Free One-Pot α-Carboxylation Of Primary Alcohols
作者:Van Der Heijden,Gydo; Et Al
参考文献:Organic & Biomolecular Chemistry 日期:2016 卷标:14(41) 页码:9716-9719]
150-30-1 = 828-01-3
反应条件:1.1 Reagents: Sodium Nitrite,Sulfuric Acid; 3 H,0 - 10 °C; 10 °C -> Rt; Overnight,Rt; Rt -> 0 °C1.2 Reagents: Sulfamic Acid; 0 °C
标题:Alternating Sequence Controlled Copolymer Synthesis Of α-Hydroxy Acids Via Syndioselective Ring-Opening Polymerization Of O-Carboxyanhydrides Using Zirconium/hafnium Alkoxide Initiators
作者:Sun,Yangyang; Et Al
参考文献:Journal Of The American Chemical Society 日期:2017 卷标:139(31) 页码:10723-10732]
17131-14-5 = 828-01-3
反应条件:1.1 Reagents: Sodium Bicarbonate,Sodium Bromide,4-Amino-2,2,6,6-Tetramethylpiperidine-1-Oxyl (Carboxy-Terminated Poly(P-Phenylenebenzobisthiazole)-Supported) Solvents: Acetonitrile,Water; 15 Min,Rt; 1.67 H,0 °C
标题:Electrooxidation Of Alcohols In An N-Oxyl-Immobilized Rigid Network Polymer Particles/water Disperse System
作者:Kubota,Jun; Et Al
参考文献:Tetrahedron 日期:2006 卷标:62(20) 页码:4769-4773]
17131-14-5 = 828-01-3
反应条件:1.1 Reagents: Sodium Bicarbonate,Sodium Carbonate Catalysts: Tempo Solvents: Water; 2 H,Rt1.2 Reagents: Amberlite Ir 120; 0.5 H,Rt
标题:Electroorganic Synthesis In Oil-In-Water (O/w) Nanoemulsion: Tempo-Mediated Electrooxidation Of Amphiphilic Alcohols In Water
作者:Kuroboshi,Manabu; Et Al
参考文献:Tetrahedron 日期:2009 卷标:65(34) 页码:7177-7185]
17131-14-5 = 828-01-3
反应条件:1.1 Reagents: Sodium Bicarbonate,Sodium Carbonate Catalysts: Tempo Solvents: Water; 2.5 H,Rt
标题:Electroorganic Synthesis In Oil-In-Water Nanoemulsion: Tempo-Mediated Electrooxidation Of Amphiphilic Alcohols In Water
作者:Yoshida,Tomonori; Et Al
参考文献:Synlett 日期:2007 卷标:(17) 页码:2691-2694]
501-52-0 = 828-01-3
反应条件:1.1 Reagents: Lithium Diisopropylamide Solvents: Tetrahydrofuran1.2 Reagents: Trimethylsilyl Peroxide
标题:α-Hydroxylation Of Carboxylic Acids And Amides Using Bis(Trimethylsilyl)Peroxide
作者:Pohmakotr,Manat; Et Al
参考文献:Synthetic Communications 日期:1988 卷标:18(16-17) 页码:2141-6
3-苯基环氧乙烷甲酸乙酯置于乙醇,镍体系中,化学反应生成 Dl-3-苯基-2-羟丙酸
参考文献:Nerdel; Rachel,Chemische Berichte,1956,Vol. 89,P. 671,675
标题:Nerdel; Rachel,Chemische Berichte,1956,Vol. 89,P. 671,675
海关参考信息
- 2902600000-乙苯
2905122000-异丙醇
2905310000-1,2-乙二醇
2905320000-1,2-丙二醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
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专利信息
专利号:US-5817751-A
优先权日:1994-06-23
标 题 :Method for synthesis of diketopiperazine and diketomorpholine derivatives
发明人：SZARDENINGS ANNA KATRIN; CAMPBELL DAVID
权利人:AFFYMAX TECH NV
摘要:The present invention relates to the areas of organic and medicinal chemistry. More specifically, the present invention is concerned with combinatorial and solid phase methods for the synthesis of diverse diketopiperazine derivatives, and the use of such methods to create libraries of diverse diketopiperazine derivatives. The present invention has application in the areas of chemical synthesis, the screening for new diketopiperazine derivatives having beneficial medical properties and the use of such screening to provide compositions and methods including diketopiperazine derivatives for treating disease.
专利号:EP-3480195-A1
优先权日:2017-11-07
标 题:Method for the synthesis of cyclic depsipeptides
权利人:BAYER ANIMAL HEALTH GMBH; THE KITASATO INST
摘要:The present invention relates to a method for the synthesis of cyclic depsipeptides, in particular emodepside, involving specific carboxylic acid group protecting tags: nTAG is preferably: nwherein m is ‰¥ 15 to ‰¤ 25, p is ‰¥ 8 to ‰¤ 18 and q is ‰¥ 15 to ‰¤ 25.
专利号:US-5656662-A
优先权日:1990-01-12
标 题:Synthesis of optically pure 4-alkenyl- or 4-alkanyl-2-hydroxytetronic acids
发明人：MANTRI PADMAJA; WITIAK DONALD T
权利人:UNIV OHIO STATE RES FOUND
摘要:The present invention relates to a method for synthesis of optically pure 4-alkenyl or 4-alkanyl-2-hydroxytetronic acids from an optically pure aldehyde. The invention further relates to the use of such optically pure compounds as potent inhibitors of platelet aggregation by working at the level of cyclooxygenase, thus making them useful in the treatment of coronary artery diseases, especially atherosclerosis, and additionally, as inhibitors of various inflammatory cytokines, making them useful in the treatment of both acute and chronic inflammation, as well in the treatment of cachexia, rheumatoid arthritis, multiple sclerosis, Crohn's disease and ulcerative colitis. The invention further relates to pharmaceutical compositions of the instant compounds.
专利号:EP-0535155-B1
优先权日:1990-06-14
标 题:Libraries of modified peptides with protease resistance
发明人：BARTLETT PAUL A; SANTI DANIEL; SIMON REYNA
权利人:CHIRON CORP; UNIV CALIFORNIA
摘要:Peptoids are provided which are polymers comprised of monomer units wherein the monomer units include at least some substitute amino acids and may include conventional amino acids. The peptoids can be synthesized in large numbers so as to provide libraries of peptoids which can be screened in order to isolate peptoids of desired biological activity. Certain peptoids are designed to mimic as closely as possible the activity of known proteins. Other peptoids are designed so as to have greater or lesser activity than known proteins and may be designed so as to block known receptor sites and/or elicit a desired immunogenic response and thereby act as vaccines. A range of different amino acid substitutes are disclosed, as are their methods of synthesis and methods of using such amino acid substitutes in the synthesis of peptoids and peptoid libraries. Methods of screening the libraries in order to obtain desired peptoids of a particular biological activity are also disclosed. The peptoids are preferably linked to a pharmaceutically active drug forming a conjugate with increased binding affinity to a particular biological receptor site.
专利号:US-6075121-A
优先权日:1990-05-15
标 题 :Modified peptide and peptide libraries with protease resistance, derivatives thereof and methods of producing and screening such
发明人：SIMON REYNA J; BARTLETT PAUL A; SANTI DANIEL V
权利人:CHIRON CORP
摘要:Peptoids are provided which are polymers comprised of monomer units wherein the monomer units include at least some substitute amino acids and may include conventional amino acids. The peptoids can be synthesized in large numbers so as to provide libraries of peptoids which can be screened in order to isolate peptoids of desired biological activity. Although the peptoids may include amino acids, they preferably include only substituted amino acids and are designed in a manner so as to have a particular biological activity. Certain peptoids are designed to mimic as closely as possible the activity of known proteins. Other peptoids are designed so as to have greater or lesser activity than known proteins and may be designed so as to block known receptor sites and/or elicit a desired immunogenic response and thereby act as vaccines. In that the peptoids are comprised of substitute amino acids they can be designed to have structures which natural proteins cannot conform to. A range of different amino acid substitutes are disclosed, as are their methods of synthesis and methods of using such amino acid substitutes in the synthesis of peptoids and peptoid libraries. Methods of screening the libraries in order to obtain desired peptoids of a particular biological activity are also disclosed. The peptoids are preferably linked to a pharmaceutically active drug forming a conjugate with increased binding affinity to a particular biological receptor site.
专利号:WO-9842730-A1
优先权日:1997-03-21
标 题:Substrates useful in both aqueous and organic media, and associated methods of preparation and use
发明人：ZUCKERMANN RONALD N; COHEN FRED E
权利人:CHIRON CORP
摘要:Novel functionalized substrates are provided having a surface which is hydrophilic in a first state and hydrophobic in a second state, so that the substrate can be used in either aqueous or organic media. The substrate surface contains a plurality of hydrophilic sites which can be readily protected and deprotected. In use, generally, a fraction of the sites are protected, leaving the remainder available for participating in organic synthetic processes to be conducted using organic reagents and solvents, e.g., solid phase organic synthesis of ligands which may or may not be oligomeric. Following synthesis, the protected hydrophilic sites are deprotected, regenerating the substrate surface in hydrophilic form for use with aqueous reagents, e.g., in screening and/or separation procedures to be conducted in aqueous media.
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主要参考文献
1: Tong S, Wang X, Shen M, Lv L, Lu M, Bu Z, Yan J. Enantioseparation of 3-phenyllactic acid by chiral ligand exchange countercurrent chromatography. J Sep Sci. 2017 Apr;40(8):1834-1842. doi: 10.1002/jssc.201601384. Epub 2017 Mar 21. doi: 10.3168/jds.2014-8645. Epub 2014 Nov 28. doi: 10.1002/chir.22340. Epub 2014 May 22. doi: 10.1016/j.ijfoodmicro.2013.12.016. Epub 2013 Dec 26. doi: 10.1007/s10529-013-1404-2. Epub 2013 Nov 19. doi: 10.1007/s00253-012-4269-8. Epub 2012 Jul 12. Review. doi: 10.1007/s00253-012-4183-0. Epub 2012 Jun 5. Epub 2012 Apr 7. doi: 10.1016/j.biortech.2009.05.024. Epub 2009 Jun 5. doi: 10.1016/j.talanta.2007.11.004. Epub 2007 Nov 13. Chinese.
14: Dieuleveux V, Guéguen M. Antimicrobial effects of D-3-phenyllactic acid on Listeria monocytogenes in TSB-YE medium, milk, and cheese. J Food Prot. 1998 Oct;61(10):1281-5.
合成参考文献
参考文献:10.1021/pr200310s
摘要:Manna SK, Patterson AD, Yang Q, Krausz KW, Idle JR, Fornace AJ, Gonzalez FJ. UPLC-MS-based urine metabolomics reveals indole-3-lactic acid and phenyllactic acid as conserved biomarkers for alcohol-induced liver disease in the Ppara-null mouse model. J Proteome Res. 2011 Sep 02;10(9):4120–33.
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尽可能描述清楚需求与问题信息
