CAS: 69398-48-7; N-(Phenylsulfonyl)Glycine Methyl Ester

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CAS号67-56-1 甲醇 | CAS号50487-70-2 Benzenesulfonam... | CAS号5398-96-9 苯磺酰基氨基乙酸 | CAS号5680-79-5 甘氨酸甲酯盐酸盐 | CAS号98-09-9 苯磺酰氯

📜甲醇,N-烯丙基苯磺酰胺置于sodium Hydroxide,臭氧体系中,用 二氯甲烷 作为反应溶剂,化学反应 2.5H,以67%的收率获得产物n-(苯磺酰基)甘氨酸甲酯
参考文献:钯催化的不对称烯丙基取代:α-和β-氨基酸的合成
标题:钯催化的不对称烯丙基取代:α-和β-氨基酸的合成
摘要:利用钯催化的烯丙基胺化作用反应生成对映体丰富的δ-氨基酸的方法已经确立.以高对映选择性反应生成了对映体丰富的烯丙基胺.烯丙基胺的氧化裂解提供了芳基甘氨酸和谷氨酸衍生物.此外,还制备出了对映体丰度很高的δ-氨基酸.钯催化的不对称烯丙基置换是合成转化的关键.
DOI:10.1039/a606586D

专利信息

专利号:US-2006211603-A1
优先权日:2004-08-18
标 题:Ramoplanin derivatives possessing antibacterial activity
发明人：RAJU BORE G; CIABATTI ROMEO; MAFFIOLI SONIA I; SINGH UPINDER; ROMANO GABRIELLA; MICHELUCCI ELENA; TISENI PAOLO S; CANDIANI GIANPAOLO; KIM BUM; O'DOWD HARDWIN
权利人:VICURON PHARM INC
摘要:Novel ramoplanin derivatives are disclosed. These ramoplanin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against gram positive bacteria, they are useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.