CAS: 68014-21-1; N-Boc-Imino-(Triphenyl)Phosphorane

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📜(4-氰基亚苄基)-氨基甲酸叔丁酯置于limcpba体系中,用 二氯甲烷,二氯甲烷-D2 作为反应溶剂,化学反应 2.0H,反应生成 N-Boc-脒三苯基膦
参考文献:N-Alkyloxycarbonyl-3-Aryloxaziridines: Their Preparation,Structure,And Utilization As Electrophilic Amination Reagents
标题:N-Alkyloxycarbonyl-3-Aryloxaziridines: Their Preparation,Structure,And Utilization As Electrophilic Amination Reagents
摘要:Abstractthis Paper Reports The Synthesis Of A Series Of N‐protected Oxaziridines (N‐m°C,B°C,Z Or Fmoc) And Discusses Their Ability To Deliver Their N‐alkoxycar‐bonyl Fragment To Amines,Enolates,Sulfur,And Phosphorus Nucleophiles (Electrophilic Amination). These Oxaziridines Are Prepared By Oxidation Of The Corresponding Imines With Oxone Or Anhydrous Mcpba Lithium Salt As The Source Of Oxygen. They Transfer Their N‐protected Fragment To Primary And Secondary Amines To Give Protected Hydrazines In Fair To Excellent Yield. The Nitrogen Transfer To Free Amino Acids (In Form Of Their R4N+ Salts) Is Particularly Fast,Even At Low Temperature,Providing L (Or D) N‐protected α‐hydrazino Acids. Enolates Are C‐aminated To Give N‐protected α‐amino Ketones,Esters,Or Amides In Modest Yield,Due To A Side Aldol Reaction Of The Unreacted Enolate With The Released Benzaldehyde. With Tertiary Amines (Et3N),Sulfides (Phsme),And Phosphines (Ph3P),Amination And Oxidation Proceed In A Parallel Way; The Amount Of Amination Product Increases When The Temperature Is Lowered (Kinetic Control). Some Of The Factors That Can Orient The Oxaziridine Reactivity Towards Amination Or Oxidation Of Nucleophiles Are Considered.
DOI:10.1002/chem.19970031019

专利信息

专利号:US-2024124910-A1
优先权日:2021-02-02
标题:Ribosome-mediated polymerization of novel chemistries
发明人：JEWETT MICHAEL CHRISTOPHER; LEE JOONGOO; ANSLYN ERIC V; CORONADO JAIME; LIM JONGDOO
权利人:UNIV NORTHWESTERN; UNIV TEXAS
摘要:Disclosed are methods, systems, components, and compositions for synthesis of sequence defined polymers. The methods, systems, components, and compositions may be utilized for incorporating novel substrates that include non-standard amino acid monomers and non-amino acid monomers into sequence defined polymers. As disclosed herein, the novel substrates may be utilized for acylation of tRNA via flexizyme catalyzed reactions. The tRNAs thus acylated with the novel substrates may be utilized in synthesis platforms for incorporating the novel substrates into a sequence defined polymer.