CAS: 64-65-3; 4-Ethyl-4-Methylpiperidine-2,6-Dione
- ⚠️《化妆品禁用原料目录》
- 英文名称4-Ethyl-4-Methylpiperidine-2,6-Dione
- 中文名称贝美格
- IUPAC名称2,6-Piperidinedione, 4-ethyl-4-methyl-
- 其它别名Glutarimide,3-ethyl-3-methyl- (8CI); 2,6-Dioxo-4-methyl-4-ethylpiperidine; 3-Ethyl-3-methylglutarimide; 3-Methyl-3-ethylglutarimide; 4-Ethyl-4-methyl-2,6-dioxopiperidine; 4-Ethyl-4-methyl-2,6-piperidinedione; 4-Methyl-4-ethyl-2,6-dioxopiperidine; Agipnon; Ahypnon; Antibarbi; Bemegrid; Bemegride; Etimid; Eukraton; Malysol; Megibal; Megimid; Megimide; Methetharimide; Mikedimide; NP 13; Zentraleptin; b-Ethyl-b-methylglutarimide; b-Methyl-b-ethylglutarimide
- CAS编号64-65-3
- MFCD编号:MFCD00006673
- EINECS号:200-588-0
- FDA UNII编号:57DQA39DO2
- 分子式:C8H13NO2分子量:155.19
- 产品CID: 1630124
- 产品分类原料药 → 神经系统用药 → 中枢兴奋药
物理性质
- 熔点126-127 °C(文献)
- 沸点279°C (粗估)
- 闪点125.8°C
- 密度1.1174 (粗估)
- pKa:pKa 11.7 (Uncertain)
- PSA:46.17
- LogP:1.1681
- 折射率1.4860 (估算)
- 蒸汽压0.00344 mmHg at 25 °C
- 溶解性DMSO:31.0(最大浓度 mg/mL);199.76(最大浓度 mM)乙醇:31.0(最大浓度 mg/mL);199.76(最大浓度 mM)
- 敏感性BEMEGRIDE is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).
- 外观形态white to off-white flakes or powder
- 储存条件本品应密封存放在阴凉,干燥处并避免光照.
MSDS等安全信息
- GHS象形图
- GHS符号GHS06;
注释: Skull and crossbones - 危险类别急性毒性 类别3(吸入)
急性毒性 类别3(经皮)
急性毒性 类别2(经口)
急性毒性 类别2(吸入)
急性毒性 类别2(经皮) - 警示词Danger(危险)
- 危险描述H331 |吸入会中毒.
H311 |皮肤接触会中毒.
H300 |吞咽致命.
H330 |吸入致命.
H310 |皮肤接触致命. - 防范说明P260-P262-P264-P270-P271-P280-P284-P301+P310+P330-P302+P352+P310+P361+P364-P304+P340+P310-P403+P233-P405-P501
- UN编号2811.0
- 危险品标志T
- 安全声明S22,S36/37/39,S45
- 危险类别码R23/24/25
- WGK Germany3
欧盟法规
ECHA物质ECHA物质化妆品禁用物质清单C&L通报REACH预注册上下游产品
3-ethyl-3-methylglutaric anhydride urea 3-ethyl-3-methylglutaric acid formamide 4-ethyl-1-[4-(α-hydroxy-benzhydryl)-piperidinomethyl]-4-methyl-piperidine-2,6-dione 4-ethyl-4-methylpiperidine 3-(4-Methyl-4-ethyl-2,6-dioxo-piperidinomethyl)-4-methyl-5-(4-methoxy-phenyl)-oxazolidin R)-4r-methyl-5c-phenyl-oxazolidin-3-ylmethyl)-piperidine-2,6-dione4-ethyl-4-methyl-1-((4R)-4r-methyl-5c-phenyl-oxazolidin-3-ylmethyl)-piperidine-2,6-dione合成工艺路线路线简述
📜Alkaline Earth Salt Of/the/ Methylsulfuric Acid 反应生成 贝美格
参考文献:Sircar,Journal Of The Chemical Society,1927,P. 602,603
标题:Sircar,Journal Of The Chemical Society,1927,P. 602,603
海关参考信息
- 2912110000-甲醛
2912120000-乙醛
2924199090-其他无环酰胺
2901100000-饱和无环烃 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Katagai H, Yasui-Furukori N, Kikuchi A, Kaneko S. Bemegride lengthens seizure duration during electric convulsive therapy in a schizophrenic patient with increased seizure threshold. J ECT. 2009 Mar;25(1):61-3. doi: 10.1097/0b013e3181723725. Ukrainian. Japanese. French. German. German. French. German. Russian.
合成参考文献
摘要:Archives Internationales de Pharmacodynamie et de Therapie., 225(88), 1977 []
摘要:Journal of Pharmacology and Experimental Therapeutics., 128(176), 1960 []
摘要:Lancet., 2(967), 1956
参考文献:10.1016/0031-9384(96)00080-7|10.1016/s0031-9384(96)00080-7
摘要:Nakano H, Saito K, Suzuki K. Clinico-ECoG correlate of megimide-induced epileptic seizures in epilepsy-prone El and its mother strain nonepileptic ddY mice. Physiol Behav. 1996 Sep;60(3):809–16. doi: 10.1016/0031-9384(96)00080-7.
参考文献:10.1007/bf03021144
摘要:MINUCK M, LAMBIE RS. The management of a post-poliolytic patient for major abdominal surgery. Can Anaesth Soc J. 1958 Oct;5(4):423–7. doi: 10.1007/bf03021144.
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