CAS: 5798-75-4; Ethyl 4-Bromobenzoate

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CAS号64-17-5 乙醇 | CAS号586-76-5 对溴苯甲酸 | CAS号34421-94-8 1,1-二苯乙烯 | CAS号106-37-6 对二溴苯 | CAS号109-94-4 甲酸乙酯 | CAS号589-87-7 对溴碘苯 | CAS号1906-57-6 乙基草酸钾 | CAS号19213-72-0 1-乙氧甲酰咪唑 | CAS号348-06-1 4-(ethyloxycarb... | CAS号125261-30-5 ethyl 4-(triflu... | CAS号10540-36-0 4'-FluoroBiphen... | CAS号398-23-2 4,4'-二氟联苯 | CAS号107430-51-3 4-(5,5,8,8-tetr... | CAS号110969-44-3 4-((叔丁氧羰基)氨基)苯甲酸乙酯 | CAS号10129-07-4 4-苯基磺酰基-苯甲酸乙酯 | CAS号3172-56-3 3,3'-双噻吩 | CAS号172035-83-5 ethyl 4-thiophe... | CAS号5933-32-4 对溴苯甲酰肼 | CAS号49742-56-5 4’-甲基[1,1’-联苯]-... | CAS号47230-38-6 4,4'-联苯二甲酸二乙酯

苯佐卡因置于盐酸,亚硝酸特丁酯,N-溴代丁二酰亚胺(Nbs),四丁基高氯酸铵体系中,用 甲醇,乙醚,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 3.5H,以60%的收率获得产物4-溴苯甲酸乙酯
参考文献:Sandmeyer反应的一般电化学策略†
标题:Sandmeyer反应的一般电化学策略†
摘要:本文中,我们报告了桑德迈尔反应的一般电化学策略.使用电作为驱动力,该协议采用一种简单且廉价的卤素源,例如nbs,Cbrcl 3,Ch 2 I 2,Ccl 4,Licl和nabr进行芳基重氮盐的卤化.另外,我们发现这些电化学反应可以以一锅的方式使用苯胺作为起始原料来进行.此外,该方法的实用性在使用非常便宜的石墨作为电极的多克规模的芳基卤化物的合成中得到了证明.已经进行了一系列详细的机理研究,包括自由基时钟和自由基清除剂研究,循环伏安分析和原位电子顺磁共振(epr)分析.
DOI:10.1039/c8Sc03346C

专利信息

专利号:US-8058477-B2
优先权日:2006-03-21
标 题 :Process for the synthesis of arylamines from the reaction of an aromatic compound with ammonia or a metal amide
发明人：HARTWIG JOHN F; SHEN QILONG
权利人:HARTWIG JOHN F; SHEN QILONG; UNIV YALE
摘要:A catalytic process for the synthesis of aromatic primary amines, reagent compositions for effecting the process, and transition metal complexes useful in the process, are provided.

专利号:WO-2019013789-A1
优先权日:2017-07-12
标 题 :ANTIMICROBIAL COMPOUNDS
发明人：REDDY HARIPRASADA R KANNA; SEBAHAR PAUL R; SERRANO CATHERINE M; LOOPER RYAN E
权利人:CURZA GLOBAL LLC; THE UNIV OF UTAH RESEARCH FOUNDATION
摘要:The invention relates to compounds of formula I or their pharmaceutically acceptable salts. The compounds of formula I are antimicrobial agents which inhibit, for example, Mycobacterium tuberculosis (Mtb) H37Ra. The compounds of formula I also have anti-tuberculous activity, exhibit limited cytotoxicity and inhibit protein synthesis. The invention also relates to methods of making compounds of formula I, as well as methods of using compounds of formula I for the treatment of bacterial infections, particularly tuberculosis.

专利号:US-5246957-A
优先权日:1991-04-24
标题 :N-imidazolyl derivatives of substituted indole
发明人：COZZI PAOLO; PILLAN ANTONIO; PULICI MAURIZIO; SALVATI PATRICIA; VOLPI ANGELO D
权利人:ERBA CARLO SPA
摘要:The invention provides N-imidazolyl derivatives of substituted indole of general formula (I) ##STR1## wherein p is an integer of 1 to 4; n A is a straight or branched C 1 -C 4 alkylene chain; n B is a direct linkage, a straight or branched, unsaturated or saturated C 1 -C 4 hydrocarbon chain; n Q is a straight or branched, saturated or unsaturated C 1 -C 9 hydrocarbon chain, or said chain is interrupted by an oxygen atom; n each of R 1 and R 2 independently is hydrogen, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 alkylthio, C 1 -C 4 alkylsulfonyl, halogen or trihalomethyl; n each of R 3 and R 5 , independently, is hydrogen or C 1 -C 4 alkyl; n R 4 is a --OR 6 or --N(R 6 R 7 ) group, wherein each of R 6 and R 7 independently is hydrogen, C 1 -C 4 alkyl, phenyl or benzyl; or a pharmaceutically acceptable salt thereof, which are useful in the treatment of a disease state in which an enhancement of TxA 2 synthesis exerts a pathogenic effect.

专利号:US-2009234126-A1
优先权日:2006-03-21
标 题:Process for the Synthesis of Arylamines from the Reaction of an Aromatic Compound with Ammonia or a Metal Amide

专利号:JP-2009530403-A
优先权日:2006-03-21
标 题 :Synthesis of arylamines from reactions of aromatic compounds with ammonia or metal amides.

专利号:CA-2646978-A1
优先权日:2006-03-21
标 题:Process for the synthesis of arylamines from the reaction of an aromaticcompounds with ammonia or a metal amide