专利号:US-7993390-B2 优先权日:2002-02-08 标 题:Implantable or insertable medical device resistant to microbial growth and biofilm formation 发明人:MILLER KATHLEEN M; BUCAY-COUTO WEENNA; LI JIANMIN 权利人:BOSTON SCIENT SCIMED INC 摘要:Disclosed are implantable or insertable medical devices that provide resistance to microbial growth on and in the environment of the device and resistance to microbial adhesion and biofilm formation on the device. In particular, the invention discloses implantable or insertable medical devices that comprise at least one biocompatible matrix polymer region, an antimicrobial agent for providing resistance to microbial growth and/or a microbial adhesion/biofilm synthesis inhibitor for inhibiting the attachment of microbes and the synthesis and accumulation of biofilm on the surface of the medical device. Also disclosed are methods of manufacturing such devices under conditions that substantially prevent preferential partitioning of any of said bioactive agents to a surface of the biocompatible matrix polymer and substantially prevent chemical modification of said bioactive agents.
专利号:RU-2417217-C2 优先权日:2004-07-21 标 题 :Salt clusters of ammonium salt and mineral salt with dibasic acid anions which are resistant and stable during storage and synthesis method thereof
1: Eucaine Lactate. Hospital (Lond 1886). 1904 Oct 15;37(942):47. 2: Ruetsch YA, Böni T, Borgeat A. From cocaine to ropivacaine: the history of local anesthetic drugs. Curr Top Med Chem. 2001 Aug;1(3):175-82. doi: 10.2174/1568026013395335. 1(3394):82-3. doi: 10.1136/bmj.1.3394.82. 4: Eucaine Lactate. Hospital (Lond 1886). 1905 May 27;38(974):153.
合成参考文献
摘要:N. Schoorl. Pharm. Weekblad. 76, 1497 (1939); CA 34, 1900.