CAS: 409108-13-0; 3-Fluoro-4-Biphenylboronic Acid
该化合物是一种有机体化合物,其特点是,在元体位置上,含有含有氟替代物的联苯结构中含有一种含有一种氟替代物的碱性酸性功能组,这种化合物通常具有极地有机溶剂中中溶性等特性,并可以参与各种化学反应,包括铃木合金,这在有机合成和药用化学中具有重大意义;该泡沫酸组允许形成可逆的二醇复合体,使其在感应应用中有用,并成为药物开发的建筑块;氟原子的存在可影响化合物的电子特性,有可能增强它的再活动性和稳定性;此外,3-氟-4-双苯乙酸可能具有独特的物理特性,例如熔点和沸点,这些受到其分子结构和分子间相互作用的影响;
物理性质
合成工艺路线路线简述
专利信息
专利号:US-10202374-B2
优先权日:2014-02-27
标题 :6-aryl-4-phenylamino-quinazoline analogs as phosphoinositide-3-kinase inhibitors
发明人：VISHWAKARMA RAM ASREY; BHARATE SANDIP BIBISHAN; BHUSHAN SHASHI; YADAV RAMMOHAN RAO; GURU SANTOSH KUMAR; JOSHI PRASHANT
权利人:COUNCIL SCIENT IND RES
摘要:The present invention relates to 6-aryl-4-phenylamino quinazolines of formula I wherein, R and R′ are as herein described. The present invention particularly relates to synthesis and anticancer and phoshpoinositide-3-kinase-α (PI3K-α) inhibitory activity. In addition, the invention relates to methods of using compounds for treating or preventing various cancers such as pancreatic, prostate, breast and melanoma.
