CAS: 30982-03-7; Iso-Butyl-Nonanoate

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nonanoic acid isobutyl chloroformate

📜壬酸,氯甲酸异丁酯 以 四氢呋喃,N-甲基吡咯烷酮 用作溶剂,化学反应 0.5H,反应生成壬酸异丁酯
参考文献:溶血素e的十四种衍生物的全合成和功能评价:阳离子,疏水和芳香部分对抗菌活性的重要性.
标题:溶血素e的十四种衍生物的全合成和功能评价:阳离子,疏水和芳香部分对抗菌活性的重要性.
摘要:溶血素e(1)是结构复杂的37元十肽,包含12个氨基酸残基,具有n-甲基化酰胺和酯键.化合物1与细菌膜中的甲萘醌(mk)结合,发挥其强大的杀菌活性.破译内这种独特的抗生素的生物学上重要的功能性,我们通过系统地改变侧链结构进行一个全面的结构-活性关系(sar)研究升-Thr-1,ð-Arg-2,N-Me-D-Phe-5,D-Arg-7,L-Glu-8和d-Trp-10.首先,我们实现的14个新的侧链类似物的全合成1通过采用固相策略.然后,我们通过1及其类似物评估了mk依赖的脂质体破坏和对金黄色葡萄球菌的抗菌活性.脂质体和细菌实验之间的相关数据表明,膜裂解主要是抗菌功能的原因.将d-Arg-2-7的阳离子胍基改变为中性酰胺,将l-Thr-1的c7-酰基取代为c2或c11对应物,其抗菌活性降低了4倍或8倍.更剧烈地是d ‐trp‐10到d的化学突变‐ala‐10完全废除了
Doi:10.1002/chem.201604022

专利信息

专利号:US-2025075143-A1
优先权日:2023-08-30
标题:Biolubricants synthesis from oil/fat ozonized-derived products
发明人：MOSIER NATHAN; LIU JUNLI
权利人:PURDUE RESEARCH FOUNDATION
摘要:Methods for making diverse high-quality biolubricants using carboxylic acid and dicarboxylic acids produced from ozone cracking of lipids. The method can include reacting a fatty acid with one or more alcohols, diols, and/or triols to esterify the fatty acid to form esters having a viscosity index of from 100 to 185, according to ASTM-D2270. The methods can also include reacting a carboxylic acid and/or dicarboxylic acid with one or more alcohols, diols, and/or triols to esterify the acid to form one or more diesters and/or oligoesters having a viscosity index of from 100 to 185, according to ASTM D 2270. The carboxylic acids and dicarboxylic acids can be nonanoic acid, malonic acid, propanoic acid, hexanoic acid, and azelaic acid, and can be derived from oxidation of one or more lipids by ozone cracking.

专利号:CA-2640585-A1
优先权日:2003-02-05
标题 :Synthesis of 2-butyl-3-(2'-(1-trityl-1h-tetrazol-5-yl)biphenyl-4-yl)-1,3-diazaspirol{4,4}-non-ene-4-one