CAS: 28862-79-5; Z-D-Leu-Oh

相似化合物

3588-60-1 103478-62-2 103478-63-3

上下游产品

CAS号328-38-1 D-亮氨酸 | CAS号501-53-1 氯甲酸苄酯 | CAS号2018-66-8 N-苄氧羰基-L-亮氨酸 | CAS号64-17-5 乙醇 | CAS号174657-99-9 (R)-4-nitrobenz... | CAS号70853-26-8 L-N-benzyloxyca... | CAS号328-39-2 (±)-氨基-4-甲基戊酸 | CAS号328-38-1 D-亮氨酸 | CAS号65581-25-1 CBZ-D-亮氨酸N-羟基琥珀酰亚胺脂

L-亮氨醇置于jones' Reagent,三乙胺体系中,用 二氯甲烷,丙酮 用作溶剂,化学反应 7.0H,反应生成N-苄氧羰基-D-亮胺酸
参考文献:Kashima,Choji; Harada,Kazuo; Fujioka,Yoko,Journal Of The Chemical Society. Perkin Transactions I,1988,P. 535-540
标题:Kashima,Choji; Harada,Kazuo; Fujioka,Yoko,Journal Of The Chemical Society. Perkin Transactions I,1988,P. 535-540

专利信息

专利号:US-7435791-B2
优先权日:2001-07-19
标题:Process for rapid solution synthesis of peptides
发明人：EGGEN IVO FRANCI; TEN KORTENAAR PAULUS BERNARDUS; HAASNOOT CORNELIS ALBERT GRUSON
权利人:ORGANON NV
摘要:The present invention relates to a process for rapid solution synthesis of a peptide, the process comprising repetitive cycles of steps (a)-(d):n (a) a coupling step, using an excess of an activated carboxylic component to acylate an amino component, (b) a quenching step in which a scavenger is used to remove residual activated carboxylic functions, wherein the scavenger may also be used for deprotection of the growing peptide, (c) one or more aqueous extractions and optionally, (d) a separate deprotection step, followed by one or more aqueous extractions, characterised in that the process comprises at least one step (b), referred to as step (b′), in which an amine or a thiol comprising a free anion or a latent anion is used as a scavenger of residual activated carboxylic functions. nn During the process of this invention the growing peptide need not be isolated until the final peptide sequence has been obtained. n This highly efficient process is useful for the production of oligo- and polypeptides of high purity.

专利号:US-11634741-B2
优先权日:2013-11-20
标 题:Synthesis of L-nucleic acids by means of an enzyme
发明人：PECH ANDREAS; JAROSCH FLORIAN; JAHNZ MICHAEL; KLUSSMANN SVEN; DAVID RALF
权利人:APTARION BIOTECH AG
摘要:The present invention is related to a method for adding one or more L-nucleotides to the 3′end of a first L-nucleic acid, wherein the method comprises the step of reacting the one or more L-nucleotides with the first L-nucleic acid in the presence of a protein comprising a mutant enzymatic activity exhibiting moiety, wherein the enzymatic activity is capable of adding one or more L-nucleotides to the 3′ end of the first L-nucleic acid, wherein the mutant enzymatic activity exhibiting moiety comprises an amino acid sequence, wherein the amino acids of the amino acid sequence are D-amino acids, wherein the mutant enzymatic activity exhibiting moiety is a variant of an enzymatic activity exhibiting moiety, wherein the enzymatic activity exhibiting moiety consists of an amino acid sequence according to SEQ ID NO: 15 and wherein the amino acids of the amino acid sequence according to SEQ ID NO: 15 are D-amino acids, wherein the amino acid sequence of the mutant enzymatic activity exhibiting moiety differs from the amino acid sequence of the enzymatic activity exhibiting moiety consisting of an amino acid sequence according to SEQ ID NO: 15 at least at one amino acid position, preferably at three amino acid positions, and/or wherein the amino acid sequence of the mutant enzymatic activity exhibiting moiety is a truncated form of an amino acid sequence according to SEQ ID NO: 15, and wherein the amino acid sequence of the mutant enzymatic activity exhibiting moiety is different from an amino acid sequence according to any of SEQ ID NOs 15 to 22 and 51.

专利号:US-6380156-B1
优先权日:1996-10-24
标 题:Total synthesis of the amino hip analogue of didemnin A
发明人：RINEHART KENNETH L; KATAUSKAS ALEXANDRA J
权利人:UNIV ILLINOIS
摘要:Disclosed is a synthetic method for the preparation of analogs of Didemnin A (1), particularly the Amino-Hip analog of Didemnin A, also known as 'AipDidemnin A' (8). These compounds have the following structures:

专利号:US-4301065-A
优先权日:1977-05-25
标 题 :Novel polypeptides having thymic activity or an antagonistic activity and processes for their synthesis
发明人：BACH JEAN-FRANCOIS; DARDENNE MIREILLE; PLEAU JEAN-MARIE; HAMBURGER JEAN; BRICAS EVANGHELOS; MARTINEZ JEAN; BLANOT DIDIER; AUGER GENEVIEVE
权利人:ANVAR
摘要:The invention is concerned with novel polypeptides and processes for the synthesis thereof. It is concerned with compounds having the sequence X-Gln-Gly-Gly-Y in which Y represents -Ser-Asn and X represents Ser-, Lys-Ser-, Ala-Lys-Ser-, Glx-Ala-Lys-Ser-; Glx representing Pyro-Glu or Gln; and when X represents Glx-Ala-Lys-Ser-, Y may in addition represent -Ser; as well as their derivatives comprising one or two modified amino acids, with the exception of the unmodified compound PyroGlu-Ala-Lys-Ser-Gln-Gly-Ser-Asn. These polypeptides are useful as medicines.

专利号:US-2018208910-A1
优先权日:2012-05-16
标 题 :Enzymatic Synthesis of L-Nucleic Acids

专利号:EP-3071702-B1
优先权日:2013-11-20
标题 :Synthesis of l-nucleic acids by means of an enzyme