CAS: 2859-68-9; 3-(Pyridin-2-yl)Propan-1-Ol

该化合物是有机化合物,其特征为:和酒精功能组;其特征为:环,由六人组成,含有一个氮原子的芳香环和丙醇侧链,表明存在一种三碳酒精;该化合物一般是无色的,可粉色黄色,有独特的味;该化合物在水和有机溶剂中溶解,可适用于各种用途;其存在时,和酒精功能都允许化学反应中可能发生相互作用,例如氢结合和核循环毒攻击;2-丙烯丙醇可用于合成药物,农用化学品和有机合成的中间体;其特性,包括沸点,熔点和活性,可根据物质的具体条件和纯度而变化;在处理该化合物时,应注意安全防范措施,因为如果吸入或吸入,可能会对健康造成危害.

结构式图片

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2739-74-4 15197-75-8 28819-26-3

物理性质

欧盟法规

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上下游产品

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合成工艺路线路线简述

  • 合成目标产物 2-Pyridinepropanol 主要起始原料 Pyridine-N-Oxide
  • (文献来源)合成步骤主要原料 Pyridine-N-Oxide
📜吡啶-N-氧化物置于镍 氢气体系中,用 四氢呋喃,乙醇 用作溶剂,-78.0~20.0 °C,5.0 Mpa 条件下,反应 5.5H,反应生成2-吡啶丙醇
参考文献:Synthèse Régiosélective Par Voie Organométallique De Pyridines,4-Picolines Et 3,5-Lutidines Substituées En 2 Par Un Groupe Insaturé Et/ou Fonctionnel
标题:Synthèse Régiosélective Par Voie Organométallique De Pyridines,4-Picolines Et 3,5-Lutidines Substituées En 2 Par Un Groupe Insaturé Et/ou Fonctionnel
摘要:
Doi:10.1016/0022-328X(87)85146-X

海关参考信息

专利信息


专利号:US-10266565-B2
优先权日:2011-04-12
标 题 :Peptide mimetic ligands of polo-like kinase 1 polo box domain and methods of use
发明人:BURKE JR TERRENCE R; LIU FA; LEE KYUNG S; PARK JUNG-EUN
权利人:BURKE JR TERRENCE R; LIU FA; LEE KYUNG S; PARK JUNG EUN; THE US SECRETARY DEPARTMENT OF HEALTH & HUMAN SERVICES
摘要:Novel compounds are provided that bind to polo-like kinases through the polo-box domain. In certain embodiments, the novel compounds are PEGylated peptides. The PEGylated peptides in accordance with the invention demonstrate high PBD-binding affinity. In certain embodiments, the PEGylated peptides have also achieved activities in whole cell systems. The invention also provides compounds that bind polo-like kinases through the polo-box domain and possess reduced anionic charge. Further provided are methods of design and/or synthesis of the PEGylated peptides and methods of use thereof. The invention provides methods of use of the compounds and methods of synthesis of the compounds.

专利号:AU-2008267444-A1
优先权日:2007-06-26
标 题 :A regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles

专利号:US-6239146-B1
优先权日:1998-06-02
标 题:Neurotrophic difluoroamide agents
发明人:VRUDHULA VIVEKANANDA M; DUBOWCHIK GENE M; DASGUPTA BIRESHWAR; VYAS DOLATRAI M
权利人:BRISTOL MYERS SQUIBB CO
摘要:The present invention relates to the design, synthesis, and the peptidyl-prolyl isomerase (PPIase or rotamase) inhibitory activity of novel alpha,alpha-difluoroacetamido compounds that are neurotrophic agents (i.e. compounds capable of stimulating growth or proliferation of nervous tissue) and that bind to immunophilins such as FKBP12 and inhibit their rotamase activity. This invention also relates to pharmaceutical compositions comprising these compounds.

专利号:CN-115160213-A
优先权日:2022-05-31
标 题:A kind of pyridinium rhein quaternary ammonium salt compound and its synthesis method and application

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合成参考文献


摘要:Dornan, L. M.; Hughes, N. L.; Muldoon, M. J., Science of Synthesis: Catalytic Oxidation in Organic Synthesis, (2017) 1, 549.
摘要:Francke, R.; Prudlik, A.; Little, R. D., Science of Synthesis: Special Topics, (2021) 1, 305.
摘要:Sasano, Y.; Iwabuchi, Y., Science of Synthesis: Special Topics, (2022) 1, 329.
摘要:M. Tissier and C. Tissier. Bull. Soc. Chim. France 1967, 3155.
参考文献:10.1007/s11030-005-7456-z
摘要:Ghassemi S, Fuchs K. Alternative method of Boc-removal from sulfamide using silica-phenyl sulfonic acid in conjunction with microwave heating. Mol Divers. 2005;9(4):295–9. doi: 10.1007/s11030-005-7456-z.
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