📜吡啶-N-氧化物置于镍 氢气体系中,用 四氢呋喃,乙醇 用作溶剂,-78.0~20.0 °C,5.0 Mpa 条件下,反应 5.5H,反应生成2-吡啶丙醇 参考文献:Synthèse Régiosélective Par Voie Organométallique De Pyridines,4-Picolines Et 3,5-Lutidines Substituées En 2 Par Un Groupe Insaturé Et/ou Fonctionnel 标题:Synthèse Régiosélective Par Voie Organométallique De Pyridines,4-Picolines Et 3,5-Lutidines Substituées En 2 Par Un Groupe Insaturé Et/ou Fonctionnel 摘要: Doi:10.1016/0022-328X(87)85146-X
专利号:US-10266565-B2 优先权日:2011-04-12 标 题 :Peptide mimetic ligands of polo-like kinase 1 polo box domain and methods of use 发明人:BURKE JR TERRENCE R; LIU FA; LEE KYUNG S; PARK JUNG-EUN 权利人:BURKE JR TERRENCE R; LIU FA; LEE KYUNG S; PARK JUNG EUN; THE US SECRETARY DEPARTMENT OF HEALTH & HUMAN SERVICES 摘要:Novel compounds are provided that bind to polo-like kinases through the polo-box domain. In certain embodiments, the novel compounds are PEGylated peptides. The PEGylated peptides in accordance with the invention demonstrate high PBD-binding affinity. In certain embodiments, the PEGylated peptides have also achieved activities in whole cell systems. The invention also provides compounds that bind polo-like kinases through the polo-box domain and possess reduced anionic charge. Further provided are methods of design and/or synthesis of the PEGylated peptides and methods of use thereof. The invention provides methods of use of the compounds and methods of synthesis of the compounds.
专利号:AU-2008267444-A1 优先权日:2007-06-26 标 题 :A regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles
专利号:US-6239146-B1 优先权日:1998-06-02 标 题:Neurotrophic difluoroamide agents 发明人:VRUDHULA VIVEKANANDA M; DUBOWCHIK GENE M; DASGUPTA BIRESHWAR; VYAS DOLATRAI M 权利人:BRISTOL MYERS SQUIBB CO 摘要:The present invention relates to the design, synthesis, and the peptidyl-prolyl isomerase (PPIase or rotamase) inhibitory activity of novel alpha,alpha-difluoroacetamido compounds that are neurotrophic agents (i.e. compounds capable of stimulating growth or proliferation of nervous tissue) and that bind to immunophilins such as FKBP12 and inhibit their rotamase activity. This invention also relates to pharmaceutical compositions comprising these compounds.
专利号:CN-115160213-A 优先权日:2022-05-31 标 题:A kind of pyridinium rhein quaternary ammonium salt compound and its synthesis method and application
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