CAS: 274693-27-5; (1S,2S,3R,5S)-3-(7-(((1R,2S)-2-(3,4-Difluorophenyl)Cyclopropyl)Amino)-5-(Propylthio)-3H-[1,2,3]Triazolo[4,5-D]Pyrimidin-3-yl)-5-(2-Hydroxyethoxy)Cyclopentane-1,2-Diol

上下游产品

CAS号1354945-69-9 (1S,2S,3R,5S)-3... | CAS号274693-26-4 异亚丙基替卡格雷 | CAS号1445580-43-7 (1S,2S,3R,5S)-3...

Tert-Butyl ((1R,2S)-2-(3,4-Difluorophenyl)Cyclopropyl)(3-((3As,4R,6S,6Ar)-6-(2-Hydroxyethoxy)-2,2-Dimethyltetrahydro-3Ah-Cyclopenta[d][1,3]Dioxol-4-yl)-5-(Propylthio)-3H-[1,2,3]Triazolo[4,5-D]Pyrimidin-7-yl)Carbamate置于磷酸体系中,用 乙醇,水 用作溶剂,化学反应 24.0H,以87%的收率获得替格瑞洛
参考文献: Synthesis Of Triazolopyrimidine Compounds[fr] Synthèse De Composés De Triazolopyrimidine
标题: Synthesis Of Triazolopyrimidine Compounds[fr] Synthèse De Composés De Triazolopyrimidine
摘要:本发明涉及有机合成领域,描述了特定三唑吡咯啉化合物及其中间体的合成,以及相关衍生物,适用于制备泰加格罗(tcg).

专利信息

专利号:US-9469614-B2
优先权日:2011-10-27
标 题:Synthesis of triazolopyrimidine compounds
发明人：ZUPANCIC BORUT; MARAS NENAD; STERK DAMJAN
权利人:LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic synthesis and describes the synthesis of specific triazolopyrimidine compounds and intermediates thereof as well as related derivatives.

专利号:EP-2607355-A1
优先权日:2011-12-23
标 题:Synthesis of triazolopyrimidine compounds
权利人:LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic synthesis and describes the synthesis of specific intermediates suitable for the preparation of triazolopyrimidine compounds such as ticagrelor.

专利号:EP-2666771-A1
优先权日:2012-05-24
标题 :Synthesis of Aminocyclopentanetriol Derivatives
发明人：STERK DAMJAN; CASAR ZDENKO
权利人:LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic synthesis and describes the synthesis of specific intermediates suitable for the preparation of triazolopyrimidine compounds such as ticagrelor. nThe present invention provides in particular a process for the preparation of a compound of formula Vn ncomprising: na) providing a compound of formula IVn n, and nb) reducing the compound of formula IV with activated zinc in the presence of copper to give the compound of formula V.

专利号:US-9278972-B2
优先权日:2011-12-23
标题 :Synthesis of triazolopyrimidine compounds
发明人：MARAS NENAD; GAZIC SMILOVIC IVANA; STERK DAMJAN
权利人:LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic synthesis and describes the synthesis of specific intermediates suitable for the preparation of triazolopyrimidine compounds such as ticagrelor.

专利号:US-9221829-B2
优先权日:2011-09-14
标题:Synthesis of triazolopyrimidine compounds
发明人：MARAS NENED; ZUPANCIC BORUT
权利人:MARAS NENED; ZUPANCIC BORUT; LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic synthesis and describes the synthesis of specific triazolopyrimidine compounds and intermediates thereof as well as related derivatives, suitable for the preparation of Ticagrelor (TCG).

专利号:EP-2644590-A1
优先权日:2012-03-30
标 题:Synthesis of 2-(3,4-difluorophenyl)cyclopropanamine derivatives and salts
权利人:LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic synthesis and describes the synthesis of specific intermediates suitable for the preparation of triazolopyrimidine compounds such as ticagrelor.