CAS: 20265-38-7; 2-Methoxypyridin-3-Amine

相似化合物

20265-35-4 28020-37-3 187654-86-0

上下游产品

2-chloro-3-aminopyridine 2-Chloro-3-nitropyridine 2-methoxy-3-nitropyridine 2-methoxy-3-pyridinecarboxamide N-(2-methoxypyridin-3-yl)acetamide 2-chloro-N-(1,2-dihydro-2-oxo-3-pyridinyl)benzene acetamide N-(2-methoxy-3-pyridyl)-2,2-dimethylpropanamide 2-chloro-N-(1,2-dihydro-2-oxo-3-pyridinyl)acetamide

2-甲氧基-3-硝基吡啶置于四丁基溴化铵,Caesium Carbonate,联硼酸频那醇酯体系中,化学反应生成2-甲氧基-3-氨基吡啶
参考文献:硝基芳烃作为亲电子试剂和芳胺替代物在 Buchwald-Hartwig 型 C-N 键构建偶联中的双重作用
标题:硝基芳烃作为亲电子试剂和芳胺替代物在 Buchwald-Hartwig 型 C-N 键构建偶联中的双重作用
摘要:构建 C(Sp 2 )-n 键最广泛使用的方法之一是过渡金属催化的芳基卤化物/硼酸与胺的交叉偶联,称为乌尔曼缩合,Buchwald-Hartwig 胺化和 Chan-拉姆联轴器.然而,芳基卤化物/硼酸通常需要多步制备,同时产生大量腐蚀性和有毒废物,使得该反应不太有吸引力.在此,我们提出了一种前所未有的方法,通过buchwald-Hartwig 型反应形成 C(Sp 2 )-n,使用合成上游硝基芳烃作为唯一起始原料,从而消除了对芳基卤化物和预先形成的芳基胺的需要.从硝基芳烃一步获得了多种对称的二芳基胺和三芳基胺,更重要的是,还通过一锅/两步法高选择性地合成了各种不对称的二芳基胺和三芳基胺.此外,放大实验的成功,药物中间体的后期功能化以及空穴传输材料tcta的快速制备展示了该方案在合成化学中的实用性和实用性.机理研究表明,这种转化可能通过硝基芳烃还原原位生成的芳胺中间体进行,随后与另一种硝基芳烃发生脱硝
Doi:10.1039/d3Sc06618E

专利信息

专利号:US-7468375-B2
优先权日:2004-04-26
标题:Inhibitors of the HIV integrase enzyme
发明人：DRESS KLAUS RUPRECHT; HU QIYUE; JOHNSON TED WILLIAM; PLEWE MICHAEL BRUNO; TANIS STEVEN PAUL; WANG HAI; YANG ANLE; YIN CHUNFENG; ZHANG JUNHU
权利人:PFIZER
摘要:The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as modulators or inhibitors of the human immunodeficiency virus (“HIVâ€?) integrase enzyme.

专利号:WO-2024041503-A1
优先权日:2022-08-22
标 题:Compounds targeting y220c mutant of p53
发明人：LI SUJING; LI AMIN; ZHENG QIAN; Dang Chaojie; FAN XINRUI; LONG WEI; WANG YANPING
权利人:JACOBIO PHARMACEUTICALS CO LTD
摘要:The present invention discloses compounds of formula (I) which can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. Also provided are processes for the synthesis and use of the compounds of formula (I).

专利号:WO-2024256496-A1
优先权日:2023-06-14
标题 :[1,2,4]-triazolo[4,3-b]pyridazine derivatives useful as a medicament
发明人：ELIE JONATHAN; GEORGE PASCAL; MIEGE FRÉDÉRIC; MEIJER LAURENT
权利人:PERHA PHARMACEUTICALS
摘要:The present invention relates to a compound of formula (I) or any of its pharmaceutically acceptable salt. The present invention further relates to a synthesis process for manufacturing compound of formula (I) or any of its pharmaceutically acceptable salts, comprising at least a step of reacting a compound of formula (II) with an amine of formula (IV) NHR5R6 for example in a molar ratio ranging from 1 to 20 eq, with respect to the compound of formula (II), in an aprotic solvent or without solvent or else in a protic solvent.

专利号:CN-116836111-A
优先权日:2023-09-01
标题 :A kind of continuous synthesis method of fluoropyridine