CAS: 20246-33-7; (2R,3R,4S,5R)-2,3,4,5,6-Pentahydroxyhexanoic Acid

专利信息

专利号:US-7652172-B2
优先权日:2004-09-20
标题:Expeditious synthesis of DPD
发明人：SEMMELHACK MARTIN F; CAMPAGNA SHAWN R; BASSLER BONNIE L; FEDERLE MICHAEL J
权利人:UNIV PRINCETON
摘要:This invention provides a practical synthesis route for 4,5-dihydroxypentane-2,3-dione (DPD), an unstable small molecule which is proposed to be the source of universal signaling agents for quorum sensing in bacteria. The synthesis route includes new intermediates and allows preparation of isotopically-labeled DPD and ent-DPD. The method provides sufficient quantities of DPD for study of spontaneous binding of borate to DPD, the signal for the marine bacteria V. harveyi.

专利号:US-11717498-B2
优先权日:2013-12-31
标题 :Methods of treatment using amphetamine controlled release, prodrug, and abuse deterrent dosage forms
发明人：POPP KARL; MECKLER HAROLD
权利人:Chemapotheca LLC; PHARMAPOTHECA A INC
摘要:The invention also relates to pharmaceutical compositions comprising highly pure amphetamine and amphetamine-class compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds, and to methods of manufacturing, delivering, and using the amphetamine compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds.

专利号:US-8685683-B2
优先权日:2008-01-10
标 题 :Method for production of vitamin C and or 2-Keto-L gulonic acid
发明人：CHEVREUX BASTIEN; MOUNCEY NIGEL JOHN
权利人:CHEVREUX BASTIEN; MOUNCEY NIGEL JOHN; DSM IP ASSETS BV
摘要:The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C) and/or 2-keto-L-gulonic acid (hereinafter also referred to as 2-KGA). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechno logical tools in the production of Vitamin C and/or 2-KGA from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C and/or 2-KGA.

专利号:US-4259443-A
优先权日:1979-02-05
标 题 :Synthesis of ascorbic acid from lactose
发明人：DANEHY JAMES P
权利人:BERNARD WOLNAK AND ASSOCIATES
摘要:A method of synthesizing vitamin C (ascorbic acid) directly from the hydrolysis products of lactose. Lactose, economically obtained from whey, undergoes hydrolysis with a warm aqueous slurry of lactase to produce D-galactose and D-glucose. Preparing the methyl glycosides of these two sugars protects a labile C-O linkage during the oxidation of the sugars to D-galacturonic acid and D-glucuronic acid. The mixture of these acids, after the removal of the methyl group through hydrolysis, undergoes reduction with gaseous hydrogen in the presence of an Adams catalyst or Raney nickel to produce a mixture of L-gulonic acid and L-galactonic acid. Removing the water from these acids forces their conversion into the corresponding lactones. Because of the applicable rate constants, adding water to the lactones does not result in their rapid reconversion to the acids. Accordingly, they can then undergo oxidation, in the presence of an enzyme obtained from pea seeds, to L-ascorbic acid.

专利号:US-2006084800-A1
优先权日:2004-06-30
标 题 :Synthesis of aldonolactones, aldarolactones, and aldarodilactones using azeotropic distillation
发明人：CHENAULT HENRY K
权利人:CHENAULT HENRY K
摘要:Processes for making lactones and dilactones from aldaric acids, aldonic acids, and their corresponding salts by dehydrative cyclization and azeotropic distillation. The processes can be carried out in the presence of water because water is removed by azeotropic distillation.

专利号:US-4326072-A
优先权日:1980-07-01
标题:Ruthenium catalyzed hydrogenation of D-glucuronic acid
发明人：KRUSE WALTER M; MESHREKI MAKRAM H
权利人:ICI AMERICA INC
摘要:A method for the synthesis of L-gulonic acid by catalytically hydrogenating D-glucuronic acid utilizing a ruthenium-based catalyst.