CAS: 1947-37-1; Tetragastrin

上下游产品

L-Tryptophyl-L-Methionyl-L-Aspartyl-L-Phenylalanine 35144-91-3
叔丁氧羰基-色氨酰-蛋氨酰-天冬氨酰-苯丙氨酰胺 N-Tert-Butoxycarbonyl-L-Tryptophyl->L-Methionyl->L-α-Aspartyl->L-Phenylalanine Amide 5235-21-2
H-Trp-Met-Asp-Oh 97586-87-3
N-叔丁氧羰基-L-色氨酸 Boc-Trp-Oh 13139-14-5
N-[(1,1-二甲基乙氧基)羰基]-L-色氨酸 4-硝基苯基酯 Boc-Trp-Onp 15160-31-3

📜L-Tryptophyl-L-Methionyl-L-Aspartyl-L-Phenylalanine置于bacillus Licheniformis Serine Endoprotease,氨体系中,用 1,4-二氧六环,N,N-二甲基甲酰胺,叔丁醇 用作溶剂,化学反应 16.0H,反应生成四肽胃泌素
参考文献:氨基酸和多肽的酶促c末端酰胺化
标题:氨基酸和多肽的酶促c末端酰胺化
摘要:在本文中,我们描述了两种通用且高产的酶促方法,可将半保护的氨基酸和肽基c末端α-羧酸转化为它们相应的酰胺.在第一种方法中,分别使用脂肪酶南极假丝酵母脂肪酶-B(cal-B),在第二种方法中,分别使用蛋白酶枯草杆菌蛋白酶a.我们发现,通过使用α-羧酸的铵盐代替单独的氨源,酶促酰胺化反应的进行速度大大加快,而没有副反应,并且使产物收率接近定量.
Doi:10.1016/j.Tetlet.2012.05.039

专利信息

专利号:US-5817751-A
优先权日:1994-06-23
标 题 :Method for synthesis of diketopiperazine and diketomorpholine derivatives
发明人：SZARDENINGS ANNA KATRIN; CAMPBELL DAVID
权利人:AFFYMAX TECH NV
摘要:The present invention relates to the areas of organic and medicinal chemistry. More specifically, the present invention is concerned with combinatorial and solid phase methods for the synthesis of diverse diketopiperazine derivatives, and the use of such methods to create libraries of diverse diketopiperazine derivatives. The present invention has application in the areas of chemical synthesis, the screening for new diketopiperazine derivatives having beneficial medical properties and the use of such screening to provide compositions and methods including diketopiperazine derivatives for treating disease.

专利号:US-11845970-B2
优先权日:2016-01-15
标 题:Endo-S2 mutants as glycosynthases, method of making and use for glycoengineering of glycoproteins
发明人：WANG LAI-XI; YANG QIANG; LI TIEZHENG; TONG XIN
权利人:UNIV MARYLAND
摘要:The present invention provides for recombinant Endo-S2 mutants (named Endo-S2 glycosynthases) that exhibit reduced hydrolysis activity and increased transglycosylation activity for the synthesis of glycoproteins wherein a desired sugar chain is added to a fucosylated or nonfucosylated GlcNAc-IgG acceptor. As such, the present invention allows for the synthesis and remodeling of therapeutic antibodies thereby providing for certain biological activities, such as, prolonged half-life time in vivo, less immunogenicity, enhanced in vivo activity, increased targeting ability, and/or ability to deliver a therapeutic agent.

专利号:US-2003147958-A1
优先权日:2002-01-29
标题 :Biodegradable multi-block copolymers of poly(amino acid)s and poly(ethylene glycol) for the delivery of bioactive agents
发明人：AHN CHEOL-HEE; CHAE SU YOUNG
摘要:This patent discloses the synthesis of a multi-block copolymer containing poly(amino acids) (PAA) and a hydrophilic polymer which are degradable under physiological conditions. Control over the degradation rate of the obtained copolymers is achieved by introducing ester, amide or urethane groups as a biodegradable linkage connecting the PAA and the hydrophilic polymer. The biodegradable multi-block copolymers display high transfection efficiency in plasmid delivery with low cytotoxicity.

专利号:US-11459380-B2
优先权日:2017-06-29
标 题 :Transglycosylation of endo-S and endo-S mutants for antibody glycosylation remodeling
发明人：WANG LAI-XI; TONG XIN; LI TIEZHENG
权利人:UNIV MARYLAND
摘要:The present invention provides for a one-pot enzymatic approach which does not require removal of the enzyme and purification of the intermediate after deglycosylation step, and the Endo-S treatment is able to do both deglycosylation and transglycosylation. The one-pot strategy of the present invention enables chemoenzymatic synthesis of an azido-tagged N-glycoform of monocloncal antibodies which could be further modified through orthogonal chemical ligation for various applications.

专利号:WO-9600391-A1
优先权日:1994-06-23
标题:Methods for the synthesis of diketopiperazines
发明人：CAMPBELL DAVID; GALLOP MARK A; GORDON ERIC M; LOOK GARY C; PATEL DINESH; SZARDENINGS ANNA KATRIN
权利人:AFFYMAX TECH NV; CAMPBELL DAVID; GALLOP MARK A; GORDON ERIC M; LOOK GARY C; PATEL DINESH; SZARDENINGS ANNA KATRIN
摘要:Libraries of diverse diketopiperazines bound to a support and methods for synthesizing diketopiperazines on a solid support are described. These libraries have utility in the area of drug design as they can be screened against biological substances to identify compounds which have desirable biological activity.

专利号:US-11702652-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries