专利号:US-8497098-B2 优先权日:2004-07-15 标题 :Biochemical synthesis of 1,4-butanediamine 发明人:EPPELMANN KATRIN; NOSSIN PETRUS M M; RAEVEN LEON J R M; KREMER SUSANNE M; WUBBOLTS MARCEL G 权利人:EPPELMANN KATRIN; NOSSIN PETRUS M M; RAEVEN LEON J R M; KREMER SUSANNE M; WUBBOLTS MARCEL G; DSM IP ASSETS BV 摘要:The invention relates to a process for biochemical synthesis of 1,4-butanediamine in a microorganism having an increased level of an ornithine decarboxylase activity (increased ODC activity) as compared to the native level of the ornithine decarboxylase activity, wherein in the microorganism also an increased activity of N-acetylglutamate formation is present as compared to the native level of activity of N-acetylglutamate formation in the microorganism and wherein 1,4-butanediamine produced in the microorganism is excreted into a fermentation broth, and is recovered from the fermentation broth. The invention also relates to vectors, plasmids and hosts carrying a corresponding increased ODC activity and an increased activity of N-acetylglutamate formation.
专利号:US-2009011478-A1 优先权日:2004-07-15 标 题:Biochemical Synthesis of 1,4-Butanediamine
专利号:US-5166426-A 优先权日:1991-04-12 标 题 :Process for producing l-carnitine from d,l-carnitine nitrile salts 发明人:JAKOB HARALD; HUTHMACHER KLAUS; KLENK HERBERT 权利人:DEGUSSA 摘要:Synthesis of L-carnitine by chemical optical resolution of D,L-carnitine nitrile salts, where the D,L-carnitine nitrile salt is reacted with optically active N-acetylproline as the resolving agent in order to form the diastereomer salts after conversion to the hydroxide form, one of the two diastereomer salts is separated by fractional crystallization and the fraction containing mainly L-carnitine nitrile salt is treated with an optically inactive strong acid in order to split off the optically active N-acetylproline and then the resolving agent is separated and the resulting L-carnitine nitrile salt is saponified to L-carnitine. N-acetyl-L-proline is used as the resolving agent and the diastereomer (LL) salt is obtained in crystalline form in a high optical purity by fractional crystallization and the L-carnitine nitrile salt obtained after splitting off and separating N-acetyl-L-proline is used directly for saponification without further crystallization.
专利号:WO-2006005603-A1 优先权日:2004-07-15 标 题 :Biochemical synthesis of 1,4-butanediamine
专利号:WO-2023086696-A2 优先权日:2021-11-10 标 题:Apparatus and methods for continuous flow synthesis of cisatracurium
专利号:EP-2949755-B1 优先权日:2004-07-15 标 题 :Biochemical synthesis of 1,4-butanediamine