CAS: 19146-55-5; Ac-D-Glu-Oh

该化合物是甲基酸的衍生物,氨基氨基酸组是乙酰酸的衍生物,可增强稳定性并改变反应性,该化合物因其在peptide合成和酶研究中作为手动建筑块的作用,在生化研究和制药应用方面特别宝贵.其乙酰组可提供保护,防止不必要的侧面反应,使其在受控化学修改中有用.D-配置为立体选择性工艺提供了具体特性,使其与更常见的L-形式相区别.该产品具有高纯度和一贯性能,确保实验和工业环境中的可靠性.

结构式图片

相似化合物

1188-37-0 2490-97-3 5875-41-2

上下游产品

Acetyl-D,L-glutaminsaeure

合成工艺路线路线简述

    (1R)-(+)-N-[1-Phenyl-(3-Phenylpropyl)]Acetamide 反应生成N-乙酰-D-谷氨酸
    参考文献:La Manna; Ghislandi; Hulbert,Farmaco,Edizione Scientifica,1967,Vol. 22,# 12,P. 1037-1053
    标题:La Manna; Ghislandi; Hulbert,Farmaco,Edizione Scientifica,1967,Vol. 22,# 12,P. 1037-1053

    海关参考信息

    专利信息


    专利号:US-8497098-B2
    优先权日:2004-07-15
    标题 :Biochemical synthesis of 1,4-butanediamine
    发明人:EPPELMANN KATRIN; NOSSIN PETRUS M M; RAEVEN LEON J R M; KREMER SUSANNE M; WUBBOLTS MARCEL G
    权利人:EPPELMANN KATRIN; NOSSIN PETRUS M M; RAEVEN LEON J R M; KREMER SUSANNE M; WUBBOLTS MARCEL G; DSM IP ASSETS BV
    摘要:The invention relates to a process for biochemical synthesis of 1,4-butanediamine in a microorganism having an increased level of an ornithine decarboxylase activity (increased ODC activity) as compared to the native level of the ornithine decarboxylase activity, wherein in the microorganism also an increased activity of N-acetylglutamate formation is present as compared to the native level of activity of N-acetylglutamate formation in the microorganism and wherein 1,4-butanediamine produced in the microorganism is excreted into a fermentation broth, and is recovered from the fermentation broth. The invention also relates to vectors, plasmids and hosts carrying a corresponding increased ODC activity and an increased activity of N-acetylglutamate formation.

    专利号:US-2009011478-A1
    优先权日:2004-07-15
    标 题:Biochemical Synthesis of 1,4-Butanediamine

    专利号:US-5166426-A
    优先权日:1991-04-12
    标 题 :Process for producing l-carnitine from d,l-carnitine nitrile salts
    发明人:JAKOB HARALD; HUTHMACHER KLAUS; KLENK HERBERT
    权利人:DEGUSSA
    摘要:Synthesis of L-carnitine by chemical optical resolution of D,L-carnitine nitrile salts, where the D,L-carnitine nitrile salt is reacted with optically active N-acetylproline as the resolving agent in order to form the diastereomer salts after conversion to the hydroxide form, one of the two diastereomer salts is separated by fractional crystallization and the fraction containing mainly L-carnitine nitrile salt is treated with an optically inactive strong acid in order to split off the optically active N-acetylproline and then the resolving agent is separated and the resulting L-carnitine nitrile salt is saponified to L-carnitine. N-acetyl-L-proline is used as the resolving agent and the diastereomer (LL) salt is obtained in crystalline form in a high optical purity by fractional crystallization and the L-carnitine nitrile salt obtained after splitting off and separating N-acetyl-L-proline is used directly for saponification without further crystallization.

    专利号:WO-2006005603-A1
    优先权日:2004-07-15
    标 题 :Biochemical synthesis of 1,4-butanediamine

    专利号:WO-2023086696-A2
    优先权日:2021-11-10
    标 题:Apparatus and methods for continuous flow synthesis of cisatracurium

    专利号:EP-2949755-B1
    优先权日:2004-07-15
    标 题 :Biochemical synthesis of 1,4-butanediamine
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    主要参考文献

    [参考文献]: Luckose F, Et Al. Effects Of Amino Acid Derivatives On Physical, Mental, And Physiological Activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.

    合成参考文献


    参考文献:10.1107/s0108270196011882
    摘要:Dobson AJ, Gerkin RE. N-Acetyl-L-glutamic Acid. Acta Crystallogr C Cryst Struct Commun. 1997 Jan 15;53(1):73–6. doi: 10.1107/s0108270196011882.
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