CAS: 188817-13-2; 5-(4-Chlorophenyl)-1-(4-Methoxyphenyl)-3-(Trifluoromethyl)-1H-Pyrazole

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CAS号99-91-2 对氯苯乙酮 | CAS号19501-58-7 4-甲氧基苯肼盐酸盐 | CAS号18931-60-7 1-(4-氯苯基)-4,4,4...

📜(4-甲氧基苯基)肼置于n-溴代丁二酰亚胺(Nbs),四(三苯基膦)钯,正丁基锂,四甲基乙二胺,Potassium Carbonate,三乙胺,对甲苯磺酰氯体系中,用 四氢呋喃,甲醇,正己烷,二氯甲烷,水,N,N-二甲基甲酰胺 用作溶剂,化学反应 17.0H,反应生成5-(4-氯苯基)-1-(4-甲氧基苯基)-3-(三氟甲基)-1H-吡唑
参考文献:使用腈亚胺和巯基乙醛作为乙炔的替代物一锅法合成 1-芳基-3-三氟甲基吡唑
标题:使用腈亚胺和巯基乙醛作为乙炔的替代物一锅法合成 1-芳基-3-三氟甲基吡唑
摘要:提出了一种使用原位生成的腈亚胺和用作 1 当量乙炔的巯基乙醛一锅法制备 1-芳基-3-三氟甲基吡唑的合成方法.该方案包括上述试剂的 (3 + 3)-环化形成 5,6-二氢-5-羟基-4 H-1,3,4-噻二嗪,然后与p-Tscl 进行级联脱水/环收缩反应.此外,还通过所设计的方法制备了在吡唑环的c(3)位上用ph,Ac和co 2 Et基团官能化的代表性非氟化类似物.
Doi:10.1021/acs.Orglett.3C01437

专利信息

专利号:US-9428486-B1
优先权日:2014-07-29
标 题 :Efficient process for the preparation of Esomeprazole (S)-Binol complex
发明人：STABILE PAOLO; BERTOLAZZI MORENO; FACCIN NICOLA; RASIA DIEGO
权利人:F I S - FABBRICA ITALIANA SINTETICI S P A; F I S —FABBRICA ITALIANA SINTETICI S P A
摘要:Object of the present invention is an improved process for the preparation of Esomeprazole (S)-BINOL complex which is a key intermediate for the synthesis of Esomeprazole and salts thereof.

专利号:US-10059674-B2
优先权日:2016-05-12
标题 :Design, synthesis, and biological evaluation of 1-methyl-1, 4-dihyrdoindeno[1,2-C]pyrazole analogues as potential anticaner agents targeting tubulin colchicine binding site
发明人：LIU ZHAOPENG; LIU YANNA; SHI YANQIU; ZHANG CHENGMEI
权利人:ACT PHARMA CO LTD
摘要:The invention discloses an indenopyrazole small-molecule tubulin inhibitor, which is characterized by having a structure represented by general formula I: n nwherein R represents NH 2 or NHOH; the invention also discloses a preparation method of the indenopyrazole compound, or pharmaceutical salts thereof. The compound of the present invention is an indenopyrazole small-molecule tubulin inhibitor having a novel structure, and has very strong proliferation inhibition activity to human hepatocellular carcinoma (HepG2) cells, human prostate carcinoma (PC3) cells, human cervical carcinoma (HeLa) cells, human breast adenocarcinoma (MCF-7) cells, and human leukemia (K562) cells; the compound is similar to colchicine in mechanism of action, and thus capable of inhibiting tubulin polymerization; the compound is significant for enhancing the specificity and effectiveness of drugs, reducing toxic and side effects, preventing drug tolerance, and so on.

专利号:CA-3018535-A1
优先权日:2015-09-25
标 题:The total synthesis of glucosepane and related chemical reactions, compounds and compositions obtained therefrom and methods of treatment

专利号:CA-2238864-C
优先权日:1995-12-15
标 题 :Method for the synthesis of a benzimidazole compound

专利号:ES-2738823-T3
优先权日:2012-07-03
标题:Heterocyclic modulators of lipid synthesis

专利号:WO-2024063740-A2
优先权日:2022-09-20
标题 :Triazole and hydrazide-hydrazone derivative hybrid molecules with antitumoral effect and the synthesis methods of these molecules