CAS: 1849590-01-7; 6'-((6-Aminopyrimidin-4-yl)Amino)-8'-Methyl-1'H-Spiro[cyclohexane-1,3'-Imidazo[1,5-A]Pyridine]-1',5'(2'H)-Dione

📜(6-((8'-Methyl-1',5'-Dioxo-1',5'-Dihydro-2'H-Spiro[cyclohexan-1,3'-Imidazolo[1,5-A]Pyridine]-6'-yl)Amino)Pyrimidin-4-yl)Carbamic Acid Tert-Butyl Ester置于盐酸体系中,用 1,4-二氧六环 用作溶剂,化学反应 0.5H,以94.9%的收率获得6'-[(6-氨基-4-嘧啶基)氨基]-8'-甲基螺[环己烷-1,3'(2'H)-咪唑并[1,5-A]吡啶]-1',5'-二酮
参考文献:化合物tomivosertib的合成新方法
标题:化合物tomivosertib的合成新方法
摘要:本发明涉及一种激酶抑制剂化合物tomivosertib的合成新方法.本发明所述的新方法,其路线选取的初始原料廉价且易得,其经过还原反应,羰基亲核加成后脱水缩合成环,再经过卤代反应后脱保护基反应合成目标分子,总步骤是4步,简化了合成制备目标化合物的工艺步骤,适合于原料药的工业化大生产的需求.

专利信息

专利号:US-2025179029-A1
优先权日:2022-03-03
标题 :Deuterated retinoidal compounds and synthesis and uses thereof
发明人：NJAR VINCENT C O; PURANIK PURUSHOTTAMACHAR; THOMAS ELIZABETH; SULOCHANA THANKAN RETHEESH
权利人:UNIV MARYLAND
摘要:The present disclosure relates to novel deuterated retinoidal compounds and methods of preparing the deuterated retinoidal compounds. The present disclosure also provides pharmaceutical compositions including the deuterated retinoidal compounds, and uses of the deuterated retinoidal compounds to treat diseases including breast and prostate cancers.

专利号:US-11286268-B1
优先权日:2019-07-02
标题:EIF4E-inhibiting compounds and methods
发明人：SPERRY SAMUEL; XIANG ALAN X; ERNST JUSTIN T; REICH SIEGFRIED H; SPRENGELER PAUL A; SHAGHAFI MIKE; MICHELS THEO; NILEWSKI CHRISTIAN; TRAN CHINH VIET; PACKARD Garrick Kenneth; GRUBBS ALAN; URKALAN KAVERI; MUKAIYAMA TAKASUKE
权利人:EFFECTOR THERAPEUTICS INC
摘要:The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. n n n n n n n n n n For Formula I compounds X 1 , X 2 , X 3 , X 4 , X 5 , X 6 , Q, L 1 , L 2 , Y, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and rings A, B and C are as defined in the specification. The inventive Formula I compounds are inhibitors of eIF4e and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.

专利号:CN-114671869-A
优先权日:2022-03-31
标题:Novel synthesis method of compound Tomivosertib