CAS: 17808-21-8; 2-Amino-3-(6-Chloro-1H-Indol-3-yl)Propanoic Acid

该化合物是一种氨酸衍生物,是一种卤化的锥虫,其特点是在蛋白环的第六位置存在氯原子,该化合物以其在生化研究和医药潜在应用中的作用而著称,具有氨酸的典型特性,包括能够参与浸泡物联结形成并充当蛋白质的构件;氯替代可影响其活性,溶性以及与生物系统的相互作用,有可能影响其在代谢途径中的作用. 6-克罗托克托邦经常用于与...

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CAS号17422-33-2 6-氯吲哚 | CAS号50517-12-9 氯克胺 | CAS号57233-85-9 N-Formyl-6-chlo... | CAS号63353-00-4 6-氯-3-二乙基氨基甲基-吲哚

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    📜二乙基(6-氯-2-吲哚基甲基)甲酰氨基-丙二酸酯置于sodium Hydroxide体系中,化学反应生成6-氯-Dl-色氨酸
    参考文献:Bz取代的吲哚和色氨酸合成实验.第三部分 四个bz-氯吲哚和-色氨酸的合成
    标题:Bz取代的吲哚和色氨酸合成实验.第三部分 四个bz-氯吲哚和-色氨酸的合成
    摘要:
    Doi:10.1039/jr9550003499

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    专利信息


    专利号:US-2022243244-A1
    优先权日:2019-10-10
    标 题 :Compositions and methods for in vivo synthesis of unnatural polypeptides
    发明人：ROMESBERG FLOYD E; FISCHER EMIL C; HASHIMOTO KOJI; FELDMAN AARON W; DIEN VIVIAN T; ZHANG YORKE
    权利人:SCRIPPS RESEARCH INST
    摘要:Disclosed herein are compositions, methods, and kits for a cell incorporating unnatural amino acids into an unnatural polypeptide. Also disclosed herein are compositions, methods, and kits for increasing activity and yield of the unnatural polypeptide synthesized by the cell.

    专利号:US-2023037284-A9
    优先权日:2018-11-30
    标题:Combination therapy of peptidomimetic macrocycles
    发明人：GUERLAVAIS VINCENT; ANNIS DAVID ALLEN
    权利人:AILERON THERAPEUTICS INC
    摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

    专利号:US-2025084410-A1
    优先权日:2015-01-12
    标 题:Incorporation of unnatural nucleotides and methods thereof
    发明人：PTACIN JEROD; MALYSHEV DENIS A; CAFFARO CAROLINA E
    权利人:SYNTHORX INC
    摘要:Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA.

    专利号:US-2018371021-A1
    优先权日:2017-05-11
    标 题 :Peptidomimetic macrocycles and uses thereof
    发明人：AIVADO MANUEL; GUERLAVAIS VINCENT; OLSON KAREN
    权利人:AILERON THERAPEUTICS INC
    摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

    专利号:WO-2021072167-A1
    优先权日:2019-10-10
    标 题:Compositions and methods for in vivo synthesis of unnatural polypeptides

    专利号:US-11091522-B2
    优先权日:2018-07-23
    标题 :Peptidomimetic macrocycles and uses thereof
    发明人：AIVADO MANUEL; GUERLAVAIS VINCENT; OLSON KAREN; ANNIS DAVID ALLEN
    权利人:AILERON THERAPEUTICS INC
    摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

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    合成参考文献


    摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2010) 2, 108.
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