CAS: 175888-75-2; N-(2,6-Dimethylphenyl)-1-Isopropylpiperidine-2-Carboxamide

英文名称N-(2,6-Dimethylphenyl)-1-Isopropylpiperidine-2-Carboxamide
中文名称N-(2,6-二甲基苯基)-1-异丙基哌啶-2-甲酰胺
IUPAC名称N-(2,6-dimethylphenyl)-1-isopropylpiperidine-2-carboxamide
其它别名Ropivacaine Impurity 17; Ropivacaine-Ipr; Ropivacaine Impurity 27/n-(2,6-Dimethylphenyl)-1-(1-Methylethyl)-2-Piperidinecarboxamide; 2-Piperidinecarboxamide, N-(2,6-Dimethylphenyl)-1-(1-Methylethyl)-; N-(2,6-Dimethylphenyl)-1-Isopropylpiperidine-2-Carboxamide
CAS编号175888-75-2
分子式:C17H26N2O分子量:274.41
产品CID: 897628
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: DLKZMUOUUWXTAZ-UHFFFAOYSA-N
InChI=1S/C17H26N2O/c1-12(2)19-11-6-5-10-15(19)17(20)18-16-13(3)8-7-9-14(16)4/h7-9,12,15H,5-6,10-11H2,1-4H3,(H,18,20)
计算化学: 氢键受体数2.0氢键供体数1.0可旋转键数3.0

相似化合物

24358-84-7 265120-58-9 1050482-18-2

MSDS等安全信息

防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

上下游产品

(S)-2',6'-pipecoloxylidide isopropyl alcoholroivacaine roivacaine

合成工艺路线路线简述

📜N-(2',6'-二甲苯基 )-2-哌啶甲酰胺置于shvo Catalyst体系中,用乙醇,二丁醚,二乙胺用作溶剂,化学反应 2.0H,反应生成罗哌卡因杂质
参考文献:Design Of An Integrated Process Of Chromatography,Crystallization And Racemization For The Resolution Of 2',6'-Pipecoloxylidide (Ppx)
标题:Design Of An Integrated Process Of Chromatography,Crystallization And Racemization For The Resolution Of 2',6'-Pipecoloxylidide (Ppx)
摘要:An Integrated Process For The Chiral Separation Of The Industrially Relevant Substance 2',6'-Pipecoloxylidide (Ppx),An Intermediate In The Manufacture Of A Number Of Anesthetics,Was Developed. By Combining Three Different Techniques,Chromatography,Crystallization,And Racemization,High Productivity Was Achieved. All Unit Operations Were Executed Using A Common Solvent System,Full Recycling,And A Minimum Of Solvent Exchanges Or Removals. The Target Molecule Was Obtained With An Enantiopurity Of >99.5 Wt %.
Doi:10.1021/op200268H