CAS: 163391-76-2; 3,4'-Dihydroxy-4,4,7,8A-Tetramethylspiro[2,3,4A,5,6,7-Hexahydro-1H-Naphthalene-8,2'-7,8-Dihydro-3H-Furo[2,3-E]Isoindole]-6'-One

该化合物是源于真菌种的活性长方形化合物,具有显著的抗微生物和细胞毒性特性,成为制药和生化研究的课题.该化合物独特的结构,以一个结合的长方形环为特点,有助于其稳定和有选择地对某些微生物菌株进行打击.初步研究表明,由于它能够抑制特定细胞路径,抗生素发展和癌症研究可能应用到抗生素发展和癌症研究中.其自然来源也为合成改造提供了一个模板,有助于进一步探索结构与活动的关系. Stachybotrylactam是调查具有有针对性的生物影响的新治疗剂的有前途的候选者.

英文名称3,4'-Dihydroxy-4,4,7,8A-Tetramethylspiro[2,3,4A,5,6,7-Hexahydro-1H-Naphthalene-8,2'-7,8-Dihydro-3H-Furo[2,3-E]Isoindole]-6'-One
中文名称杂色曲霉毒素
CAS编号163391-76-2
MFCD编号:MFCD32645034
分子式:C23H31NO4分子量:385.5
产品CID: 828602
产品分类天然产物 → 倍半萜

相似结构搜索
产品信息参考;;
InChIKey: ZSVLMDBFFSSVAK-UHFFFAOYNA-N
1S/C23H31NO4/c1-12-5-6-17-21(2,3)18(26)7-8-22(17,4)23(12)10-14-16(25)9-13-15(19(14)28-23)11-24-20(13)27/h9,12,17-18,25-26H,5-8,10-11H2,1-4H3,(H,24,27)
计算化学: 氢键受体数4.0氢键供体数3.0可旋转键数0.0

物理性质

熔点210°C (分解) (ethyl acetate )
沸点630.0±55.0 °C(预测)
闪点334.8±31.5 °C
密度1.28±0.1 g/cm3(预测)
pKa:9.39±0.70(预测)
PSA:82.28
LogP:3.553
溶解性DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble
储存条件-20°C

上下游产品

(2)R,2'R,4'aS,6'R,8'aS]-6'-hydroxy-7-cyano-3',4',4'a,5',6',7',8',8'a-°Ctahydro-2',5',5',8'a-tetramethylspiro[benzofuran-2(3H),1'(2'H)-naphthalene]-6-carboxylic acid methyl ester[1'(2)R,2'R,4'aS,6'R,8'aS]-6'-hydroxy-7-cyano-3',4',4'a,5',6',7',8',8'a-°Ctahydro-2',5',5',8'a-tetramethylspiro[benzofuran-2(3H),1'(2'H)-naphthalene]-6-carboxylic acid methyl ester (-)-(4aS,6R,8aS)-3,4,4a,5,6,7,8,8a-°Ctahydro-6-benzyloxy-5,5,8a-trimethyl-1(2H)-naphthalenone [2R,4aS,6R,8aS]-6-benzyloxy-2,5,5,8a-tetramethyl-3,4,4a,5,6,7,8,8a-°Ctahydronaphthalene-1-carbaldehyde (2)R,2'R,4'aS,6'R,8'aS]-4,6'-dihydroxy-3',4',4'a,5',6',7',8',8'a-°Ctahydro-2',5',5',8'a-tetramethylspiro[benzofuran-2(3H),1'(2'H)-naphthalene]-6-carboxylic acid methyl ester[1'(2)R,2'R,4'aS,6'R,8'aS]-4,6'-dihydroxy-3',4',4'a,5',6',7',8',8'a-°Ctahydro-2',5',5',8'a-tetramethylspiro[benzofuran-2(3H),1'(2'H)-naphthalene]-6-carboxylic acid methyl ester