CAS: 150766-86-2; 4'-(Bromomethyl)-[1,1'-Biphenyl]-2-Carboxylic Acid
该化合物是一种双联苯衍生物,其成分既包括箱式酸,也包括一种溴甲基功能组,使其成为有机合成的多用途中间体.溴甲基组可以产生显性核细胞替代反应,而箱式酸会允许通过洗涤或恐吓进一步衍生.这种化合物在制药和材料化学中特别有用,是准备更复杂的分子的建筑块.其硬性联苯基骨有助于结构稳定,反应场为有针对性的修改提供了灵活性.高纯度和一贯的质量可以确保研究和工业应用的可靠性能.
- 英文名称4'-(Bromomethyl)-[1,1'-Biphenyl]-2-Carboxylic Acid
- 中文名称4'-(溴甲基)-[1,1'-联苯]-2-羧酸
- IUPAC名称4'-(bromomethyl)-[1,1'-biphenyl]-2-carboxylic acid
- 其它别名Telmisartan Impurity 18; Telmisartan-Bromo Acid Impurity; Telmisartan Bromo Acid Impurity (4-Bromomethylbiphenyl-2'-Carboxylic Acid); 4-Bromomethylbiphenyl-2'-Carboxylic Acid; 4-Bromomethylbiphebyl-2'-Carboxylic Acid; Telmisartan Bromo Acid; 2-[4-(Bromomethyl)Phenyl]Benzoic Acid
- CAS编号150766-86-2
- MFCD编号:MFCD06208233
- FDA UNII编号:GJZ4CBL79Q
- 分子式:C14H11BrO2分子量:291.14
- 产品CID: 732704
- 产品分类有机原料→分子砌块→芳环类化合物→苯类化合物
相似化合物
114772-38-2 114772-40-6 114772-54-2物理性质
MSDS等安全信息
上下游产品
CAS号7148-03-0 2-(对甲苯基)苯甲酸 | CAS号118-92-3 邻氨基苯甲酸合成工艺路线路线简述
- 合成目标产物 4-Bromomethylbiphebyl-2'-Carboxylic Acid 主要起始原料 4'-Methylbiphenyl-2-Carboxylic Acid
- (文献来源)合成步骤主要原料 4'-Methylbiphenyl-2-Carboxylic Acid
📜4'-甲基联苯-2-羧酸置于n-溴代丁二酰亚胺(Nbs),2-(2-Cyanopropan-2-Yldiazenyl)-2-Methylpropanenitrile体系中,用 甲醇,乙酸甲酯,水 用作溶剂,以82.5%的收率获得4-(溴甲基)-[1,1-联苯]-2-羧酸
参考文献:Process For Brominating The Side Chain Of 4-Methylbiphenyl Derivatives Substituted In The 2' Position
标题:Process For Brominating The Side Chain Of 4-Methylbiphenyl Derivatives Substituted In The 2' Position
摘要:一种制备2'位置取代的4-溴甲基联苯衍生物的方法,通过对2'位置取代的4-甲基联苯衍生物进行溴化,通式(I)为:其中:R为cn,Coor1,Conr1R2或c(Or3)Hnr4,或者选择性地被苄基,甲氧羰基,乙氧羰基,9-芴甲氧羰基,2,2,2-三氯乙氧羰基,苄氧羰基,叔丁氧羰基,烯丙氧羰基,三氯乙酰基,三氟乙酰基或三苄基取代的5-四唑基;R1和r2相同或不同,为氢或c1-C6-烷基;R3和r4共同形成c2-C3烷基桥,可选择性地通过一个或多个甲基,乙基,正丙基,异丙基,正丁基,异丁基,叔丁基,苯基或萘基取代一次,二次,三次或四次,溴化通过有机羧酸酯溶剂中的n-溴代亚胺或n-溴代酰胺进行.
海关参考信息
- 2905110000-甲醇
2906210000-苄醇
2912110000-甲醛
2912210000-苯甲醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:EP-2149566-A1
优先权日:2008-07-15
标 题 :A process for the preparation of telmisartan
发明人：ROSSI RENZO; BELLINA FABIO; CAUTERUCCIO SILVIA; CASTALDI GRAZIANO
权利人:CHEMO IBERICA SA
摘要:The present invention relates to a process for the preparation of Telmisartan by hydroxycarbonylation of compound of formula (V),n nwherein X is a substituent which can be transformed into a carboxy group by hydroxycarbonylation. The invention also relates to intermediates for the synthesis of Telmisartan.
专利号:US-7968727-B2
优先权日:2005-04-01
标 题 :Synthesis of 4-bromomethyl-2′-formylbiphenyl and 4-bromomethyl-2′-hydroxymethylbiphenyl and its use in preparation of angiotensin II antagonists
发明人：COPAR ANTON; ANTONCIC LJUBOMIR; ANTONCIC MATEJ
权利人:LEK PHARMACEUTICALS
摘要:4-bromomethyl-2′-formylbiphenyl and 4-bromomethyl-2′-hydroxymethylbiphenyl are useful starting material for the preparation various angiotenzin II antagonists, which are prepared from 4-bromomethyl-2′-cyanobiphenyl or 4′-bromomethylbiphenylcarboxyilic derivatives using selected hydride reagent.
专利号:US-2009318521-A1
优先权日:2005-04-01
标题 :Synthesis of 4-Bromomethyl-2'-Formylbiphenyl and 4-Bromomethyl-2'-Hydroxymethylbiphenyl and Its Use in Preparation of Giotensin II Antagonists
专利号:WO-2006103068-A1
优先权日:2005-04-01
标题:A synthesis of 4-bromomethyl-2'-formylbiphenyl and 4-bromomethyl-2'- hydroxymethylbiphenyl and its use in preparation of angiotensin ii antagonists
专利号:EP-1871764-A1
优先权日:2005-04-01
标 题:A synthesis of 4-bromomethyl-2'-formylbiphenyl and 4-bromomethyl-2'- hydroxymethylbiphenyl and its use in preparation of angiotensin ii antagonists
专利号:WO-2016089845-A1
优先权日:2014-12-01
标 题 :A convergent approach to the total synthesis of telmisartan via a suzuki cross-coupling reaction
